2W5Z

Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HISTONE-LYSINE N-METHYLTRANSFERASE HRX	polymer	192	22181.4	1	UniProt (Q03164) Pfam (PF00856) In PDB	HOMO SAPIENS (HUMAN)	ZINC FINGER PROTEIN HRX, ALL-1, TRITHORAX-LIKE PROTEIN, LYSINE N-METHYLTRANSFERASE 2A, CXXC-TYPE ZINC FINGER PROTEIN 7, MLL-1
2	C	HISTONE PEPTIDE	polymer	9	1124.3	1	UniProt (by SIFTS) (P68433) In PDB	HOMO SAPIENS (HUMAN)
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)
5	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6		water	water		18.0	64	Chemie (HOH)

Sequence modifications

A: 3778 - 3784 (PDB: 2W5Z)
A: 3785 - 3969 (UniProt: Q03164)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	23305.7
Non-Polymers*	Number of molecules	4
	Total formula weight	634.0
All*	Total formula weight	23939.7

*Water molecules are not included.