2W5Z

Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide.

Summary for 2W5Z

• Entry DOI: 10.2210/pdb2w5z/pdb
• Related: 2AGH 2J2S 2W5Y
• Descriptor: HISTONE-LYSINE N-METHYLTRANSFERASE HRX, HISTONE PEPTIDE, ZINC ION, ... (6 entities in total)
• Functional Keywords: transcription regulation, chromosomal rearrangement, protein lysine methyltransferase, proto-oncogene, phosphoprotein, ubl conjugation, s-adenosyl-l-methionine, mixed lineage leukaemia, polymorphism, transcription, metal-binding, zinc-finger, dna-binding, bromodomain, transferase, methyltransferase, chromatin regulator, alternative splicing, histone modification, mll1, zinc, kmt2a, nucleus, apoptosis, set domain
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• Total number of polymer chains: 2
• Total formula weight: 23939.70

Authors

Southall, S.M.,Wong, P.S.,Odho, Z.,Roe, S.M.,Wilson, J.R. (deposition date: 2008-12-15, release date: 2009-02-10, Last modification date: 2011-07-13)

• Primary citation: Southall, S.M.,Wong, P.S.,Odho, Z.,Roe, S.M.,Wilson, J.R.; Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.; Mol.Cell, 33:181-, 2009; PubMed: 19187761; DOI: 10.1016/J.MOLCEL.2008.12.029

Experimental method

X-RAY DIFFRACTION (2.2 Å)