2W3B

HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	DIHYDROFOLATE REDUCTASE	polymer	187	21480.7	2	UniProt (P00374) Pfam (PF00186) In PDB	HOMO SAPIENS (HUMAN)
2	A, B	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	A, B	6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE	non-polymer		368.4	2	Chemie (VG9)
4	A, B	FOLIC ACID	non-polymer		441.4	2	Chemie (FOL)
5	A, B	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
6		water	water		18.0	573	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42961.4
Non-Polymers*	Number of molecules	8
	Total formula weight	3188.7
All*	Total formula weight	46150.1

*Water molecules are not included.