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2W3B

HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)

Summary for 2W3B
Entry DOI10.2210/pdb2w3b/pdb
Related1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3M
DescriptorDIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, ... (6 entities in total)
Functional Keywordsnonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight46150.14
Authors
Leung, A.K.W.,Reynolds, R.C.,Borhani, D.W. (deposition date: 2008-11-11, release date: 2009-11-17, Last modification date: 2019-05-08)
Primary citationLeung, A.K.W.,Ross, L.J.,Zywno-Van Ginkel, S.,Reynolds, R.C.,Seitz, L.E.,Pathak, V.,Barrow, W.W.,White, E.L.,Suling, W.J.,Piper, J.R.,Borhani, D.W.
Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate
To be Published,
Experimental method
X-RAY DIFFRACTION (1.27 Å)
Structure validation

217705

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