2VZE
Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL | polymer | 570 | 63334.6 | 3 | UniProt (Q08AH3) Pfam (PF00501) Pfam (PF13193) In PDB | HOMO SAPIENS (HUMAN) | ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A, MIDDLE-CHAIN ACYL-COA SYNTHETASE 2A, BUTYRYL COENZYME A SYNTHETASE 2A, BUTYRATE--COA LIGASE 2A |
| 2 | A, B, C | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 3 | Chemie (AMP) | |||
| 3 | C | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 655 | Chemie (HOH) |
Sequence modifications
A, B, C: 32 - 577 (UniProt: Q08AH3)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | expression tag |
| Gly 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Val 19 | - | expression tag |
| Asp 20 | - | expression tag |
| Leu 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Thr 23 | - | expression tag |
| Glu 24 | - | expression tag |
| Asn 25 | - | expression tag |
| Leu 26 | - | expression tag |
| Tyr 27 | - | expression tag |
| Phe 28 | - | expression tag |
| Gln 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Met 31 | - | expression tag |
| Pro 64 | Leu 64 | engineered mutation |
| Asp 463 | Asn 463 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 190003.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1066.0 | |
| All* | Total formula weight | 191069.7 |
