2OUV
crystal structure of pde10a2 mutant of D564N
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 331 | 38305.1 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (human) | |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 458 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 776 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ser 446 | - | cloning artifact |
| His 447 | - | cloning artifact |
| Met 448 | - | cloning artifact |
| Asn 564 | Asp 554 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76610.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 179.4 | |
| All* | Total formula weight | 76789.6 |
