2O8H
Crystal structure of the catalytic domain of rat phosphodiesterase 10A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphodiesterase-10A | polymer | 362 | 41661.7 | 1 | UniProt (Q9QYJ6) Pfam (PF00233) In PDB | Rattus norvegicus (Norway rat) | PDE10A2 |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | 6,7-DIMETHOXY-4-{8-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL}QUINAZOLINE | non-polymer | 483.6 | 1 | Chemie (227) | |||
| 5 | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A: 442 - 784 (UniProt: Q9QYJ6)
| PDB | External Database | Details |
|---|---|---|
| Met 423 | - | initiating methionine |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
| His 426 | - | expression tag |
| His 427 | - | expression tag |
| His 428 | - | expression tag |
| His 429 | - | expression tag |
| Ser 430 | - | cloning artifact |
| Ser 431 | - | cloning artifact |
| Gly 432 | - | cloning artifact |
| Leu 433 | - | cloning artifact |
| Val 434 | - | cloning artifact |
| Pro 435 | - | cloning artifact |
| Arg 436 | - | cloning artifact |
| Gly 437 | - | cloning artifact |
| Ser 438 | - | cloning artifact |
| Ala 439 | - | cloning artifact |
| Met 440 | - | cloning artifact |
| Gly 441 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41661.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 573.3 | |
| All* | Total formula weight | 42235.0 |
