2HBU
Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Egl nine homolog 1 | polymer | 247 | 27832.7 | 1 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | Homo sapiens (human) | Hypoxia-inducible factor prolyl hydroxylase 2, HIF-prolyl hydroxylase 2, HIF-PH2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20 |
2 | A | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
3 | A | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE | non-polymer | 280.7 | 1 | Chemie (UN9) | |||
4 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A: 188 - 426 (UniProt: Q9GZT9)
PDB | External Database | Details |
---|---|---|
Met 180 | - | cloning artifact |
Ala 181 | - | cloning artifact |
His 182 | - | cloning artifact |
His 183 | - | cloning artifact |
His 184 | - | cloning artifact |
His 185 | - | cloning artifact |
His 186 | - | cloning artifact |
His 187 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 27832.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 336.5 | |
All* | Total formula weight | 28169.2 |