2BW7

A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	ADENYLATE CYCLASE	polymer	219	24189.7	4	UniProt (O32393) Pfam (PF00211) In PDB	SPIRULINA PLATENSIS	SOLUBLE ADENYLYL CYCLASE CYAC
2	A, B, C, D	DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	non-polymer		505.2	4	Chemie (APC)
3	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	A, B, C, D	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
5	A, B	2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE	non-polymer		288.4	2	Chemie (ECS)
6		water	water		18.0	139	Chemie (HOH)

Sequence modifications

A, B, C, D: 984 - 1004 (PDB: 2BW7)
A, B, C, D: 1005 - 1199 (UniProt: O32393)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	96758.7
Non-Polymers*	Number of molecules	14
	Total formula weight	2855.1
All*	Total formula weight	99613.8

*Water molecules are not included.