2BW7

A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen

Summary for 2BW7

Entry DOI	10.2210/pdb2bw7/pdb
Related	1WC0 1WC1 1WC3 1WC4 1WC5 1WC6
Descriptor	ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	lyase, adenylyl cyclase, camp signaling, catechol estrogen, inhibitor complex, oxidoreductase
Biological source	SPIRULINA PLATENSIS
Total number of polymer chains	4
Total formula weight	99613.84
Authors	Steegborn, C.,Litvin, T.N.,Hess, K.C.,Capper, A.B.,Taussig, R.,Buck, J.,Levin, L.R.,Wu, H. (deposition date: 2005-07-12, release date: 2005-07-20, Last modification date: 2011-07-13)
Primary citation	Steegborn, C.,Litvin, T.N.,Hess, K.C.,Capper, A.B.,Taussig, R.,Buck, J.,Levin, L.R.,Wu, H. A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen J.Biol.Chem., 280:31754-, 2005 Cited by PubMed: 16002394 DOI: 10.1074/JBC.M507144200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation