2BAN
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Reverse transcriptase P66 subunit | polymer | 560 | 64501.0 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus 1 | HIV-1 RT |
| 2 | B | Reverse transcriptase P51 subunit | polymer | 430 | 50281.8 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus 1 | HIV-1 RT |
| 3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | A | 5-ETHYL-3-[(2-METHOXYETHYL)METHYLAMINO]-6-METHYL-4-(3-METHYLBENZYL)PYRIDIN-2(1H)-ONE | non-polymer | 328.4 | 1 | Chemie (357) | |||
| 5 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 430 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 878 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 878 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114782.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 383.4 | |
| All* | Total formula weight | 115166.1 |
