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2BAN

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208

Summary for 2BAN
Entry DOI10.2210/pdb2ban/pdb
Related1S6P 1S6Q 1SV5 2B5J 2BE2
DescriptorReverse transcriptase P66 subunit, Reverse transcriptase P51 subunit, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywordsaids, hiv, drug design, reverse transcriptase, rt, protein-inhibitor complex, transferase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains2
Total formula weight115166.11
Authors
Das, K.,Arnold, E. (deposition date: 2005-10-14, release date: 2005-12-06, Last modification date: 2023-08-23)
Primary citationHimmel, D.M.,Das, K.,Clark Jr., A.D.,Hughes, S.H.,Benjahad, A.,Oumouch, S.,Guillemont, J.,Coupa, S.,Poncelet, A.,Csoka, I.,Meyer, C.,Andries, K.,Nguyen, C.H.,Grierson, D.S.,Arnold, E.
Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains.
J.Med.Chem., 48:7582-7591, 2005
Cited by
PubMed: 16302798
DOI: 10.1021/jm0500323
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.95 Å)
Structure validation

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