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1YHQ

Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1023S Ribosomal RNApolymer2922946141.41GenBank (55229667)Haloarcula marismortui
295S Ribosomal RNApolymer12239303.41GenBank (3377778)Haloarcula marismortui
3A50S ribosomal protein L2Ppolymer24025354.71UniProt (P20276)
Pfam (PF00181)
Pfam (PF03947)
In PDB		Haloarcula marismortui
4B50S ribosomal protein L3Ppolymer33837396.41GenBank (55378384)
Pfam (PF00297)
UniProt (by SIFTS) (P20279)
In PDB		Haloarcula marismortui
5C50S ribosomal protein L4Epolymer24626442.11UniProt (P12735)
Pfam (PF00573)
In PDB		Haloarcula marismortui
6D50S ribosomal protein L5Ppolymer17719551.71UniProt (P14124)
Pfam (PF00281)
Pfam (PF00673)
In PDB		Haloarcula marismortui
7E50S ribosomal protein L6Ppolymer17819961.71UniProt (P14135)
Pfam (PF00347)
In PDB		Haloarcula marismortui
8F50S ribosomal protein L7AEpolymer12012791.91UniProt (P12743)
Pfam (PF01248)
In PDB		Haloarcula marismortui
9GACIDIC RIBOSOMAL PROTEIN P0 HOMOLOGpolymer34837213.81UniProt (P15825)
Pfam (PF00466)
Pfam (PF17777)
In PDB		Haloarcula marismortui
10H50S RIBOSOMAL PROTEIN L10Epolymer17719942.71GenBank (55231756)
Pfam (PF00252)
UniProt (by SIFTS) (P60617)
In PDB		Haloarcula marismortui
11I50S RIBOSOMAL PROTEIN L11Ppolymer16217097.51GenBank (132647)
Pfam (PF03946)
Pfam (PF00298)
UniProt (by SIFTS) (P14122)
In PDB		Haloarcula marismortui
12J50S ribosomal protein L13Ppolymer14516249.21UniProt (P29198)
Pfam (PF00572)
In PDB		Haloarcula marismortui
13K50S ribosomal protein L14Ppolymer13214191.21UniProt (P22450)
Pfam (PF00238)
In PDB		Haloarcula marismortui
14L50S ribosomal protein L15Ppolymer16518005.41UniProt (P12737)
Pfam (PF00828)
In PDB		Haloarcula marismortui
15M50S Ribosomal Protein L15Epolymer19422143.91GenBank (55231501)
Pfam (PF00827)
UniProt (by SIFTS) (P60618)
In PDB		Haloarcula marismortui
16N50S ribosomal protein L18Ppolymer18720640.91UniProt (P14123)
Pfam (PF17144)
In PDB		Haloarcula marismortui
17O50S ribosomal protein L18epolymer11612438.91UniProt (P12733)
Pfam (PF00828)
In PDB		Haloarcula marismortui
18P50S ribosomal protein L19Epolymer14916796.51UniProt (P14119)
Pfam (PF01280)
In PDB		Haloarcula marismortui
19Q50S ribosomal protein L21epolymer9610567.81UniProt (P12734)
Pfam (PF01157)
In PDB		Haloarcula marismortui
20R50S ribosomal protein L22Ppolymer15516966.91UniProt (P10970)
Pfam (PF00237)
In PDB		Haloarcula marismortui
21S50S ribosomal protein L23Ppolymer859612.51UniProt (P12732)
Pfam (PF00276)
In PDB		Haloarcula marismortui
22T50S ribosomal protein L24Ppolymer12013671.01UniProt (P10972)
Pfam (PF16906)
Pfam (PF00467)
In PDB		Haloarcula marismortui
23U50S ribosomal protein L24Epolymer667233.71UniProt (P14116)
Pfam (PF01246)
In PDB		Haloarcula marismortui
24V50S ribosomal protein L29Ppolymer717889.91UniProt (P10971)
Pfam (PF00831)
In PDB		Haloarcula marismortui
25W50S ribosomal protein L30Ppolymer15417062.91UniProt (P14121)
Pfam (PF00327)
In PDB		Haloarcula marismortui
26X50S ribosomal protein L31epolymer9210384.61UniProt (P18138)
Pfam (PF01198)
In PDB		Haloarcula marismortui
27Y50S ribosomal protein L32Epolymer24126455.71UniProt (P12736)
Pfam (PF14520)
Pfam (PF01655)
In PDB		Haloarcula marismortui
28Z50S ribosomal protein L37Aepolymer839409.31GenBank (55231162)
Pfam (PF01780)
UniProt (by SIFTS) (P60619)
In PDB		Haloarcula marismortui
29150S ribosomal protein L37epolymer576330.21UniProt (P32410)
Pfam (PF01907)
In PDB		Haloarcula marismortui
30250S ribosomal protein L39epolymer506133.11UniProt (P22452)
Pfam (PF00832)
In PDB		Haloarcula marismortui
31350S ribosomal protein L44Epolymer9210815.21UniProt (P32411)
Pfam (PF00935)
In PDB		Haloarcula marismortui
320AZITHROMYCINnon-polymer749.01Chemie (ZIT)
330, K, 9, A, B...MAGNESIUM IONnon-polymer24.393Chemie (MG)
340POTASSIUM IONnon-polymer39.12Chemie (K)
350, M, 9, Q, R...SODIUM IONnon-polymer23.075Chemie (NA)
36L, 0, M, N, O...CHLORIDE IONnon-polymer35.522Chemie (CL)
370, 9, A, R, S...STRONTIUM IONnon-polymer87.6108Chemie (SR)
38O, U, Z, 1, 3CADMIUM IONnon-polymer112.45Chemie (CD)
39waterwater18.07763Chemie (HOH)
Sequence modifications
0: 1 - 2922 (GenBank: 55229667)
PDBExternal DatabaseDetails
1ma 628A 627modified residue
A 2099G 2098engineered mutation
Omu 2587U 2586modified residue
Omg 2588G 2587modified residue
Ur3 2619U 2618modified residue
Psu 2621U 2620modified residue
K: 1 - 132 (UniProt: P22450)
PDBExternal DatabaseDetails
Leu 44His 44conflict
M: 1 - 194 (GenBank: 55231501)
PDBExternal DatabaseDetails
Glu 13Lys 14conflict
Z: 10 - 92 (GenBank: 55231162)
PDBExternal DatabaseDetails
Arg 10Ser 34conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains31
Total formula weight1474196.4
Non-Polymers*Number of molecules306
Total formula weight15616.8
All*Total formula weight1489813.1
*Water molecules are not included.

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PDB entries from 2024-04-24

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