1B4J
COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | L | ANTIBODY | polymer | 214 | 23624.2 | 1 | EMBL (X95750) | Homo sapiens (human) | |
| 2 | H | ANTIBODY | polymer | 220 | 23465.3 | 1 | Homo sapiens (human) |
Sequence modifications
L: 3 - 214 (EMBL: X95750)
| PDB | External Database | Details |
|---|---|---|
| Lys 9 | Ser 31 | conflict |
| Met 11 | Leu 33 | conflict |
| Tyr 12 | Ser 34 | conflict |
| Val 13 | Ala 35 | conflict |
| Ser 14 | Phe 36 | conflict |
| Ile 15 | Val 37 | conflict |
| Glu 17 | Asp 39 | conflict |
| Leu 21 | Ile 43 | conflict |
| Ser 22 | Thr 44 | conflict |
| Lys 24 | Arg 46 | conflict |
| Glu 27 | Gln 49 | conflict |
| Asn 28 | Ser 50 | conflict |
| Val 29 | Ile 51 | conflict |
| Asp 30 | Ser 52 | conflict |
| Thr 31 | Ser 53 | conflict |
| Val 33 | Leu 55 | conflict |
| Ser 34 | Asn 56 | conflict |
| Glu 41 | Gly 63 | conflict |
| Gln 42 | Lys 64 | conflict |
| Ser 43 | Ala 65 | conflict |
| Gly 50 | Ala 72 | conflict |
| Asn 53 | Ser 75 | conflict |
| Arg 54 | Leu 76 | conflict |
| Tyr 55 | Gln 77 | conflict |
| Thr 56 | Ser 78 | conflict |
| Asp 60 | Ser 82 | conflict |
| Thr 63 | Ser 85 | conflict |
| Ala 68 | Gly 90 | conflict |
| Val 78 | Leu 100 | conflict |
| Ala 80 | Pro 102 | conflict |
| Leu 83 | Phe 105 | conflict |
| Asp 85 | Thr 107 | conflict |
| His 87 | Tyr 109 | conflict |
| Gly 89 | Gln 111 | conflict |
| Tyr 92 | His 114 | conflict |
| Asn 93 | Ser 115 | conflict |
| Tyr 94 | Thr 116 | conflict |
| Phe 96 | Tyr 118 | conflict |
| Ser 100 | Gln 122 | conflict |
| Lys 103 | Asn 125 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47089.5 | |
| All* | Total formula weight | 47089.5 |
