1B4J

COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY

Summary for 1B4J

Entry DOI	10.2210/pdb1b4j/pdb
Descriptor	ANTIBODY (2 entities in total)
Functional Keywords	antibody engineering, humanized and chimeric antibodies, fab, x-ray structures, gamma-interferon
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	47089.50
Authors	Fan, Z.,Shan, L.,Goldsteen, B.Z.,Guddat, L.W.,Thakur, A.,Landolfi, N.F.,Co, M.S.,Vasques, M.,Queen, C.,Ramsland, P.A.,Edmundson, A.B. (deposition date: 1998-12-22, release date: 1999-06-15, Last modification date: 2023-08-02)
Primary citation	Fan, Z.C.,Shan, L.,Goldsteen, B.Z.,Guddat, L.W.,Thakur, A.,Landolfi, N.F.,Co, M.S.,Vasquez, M.,Queen, C.,Ramsland, P.A.,Edmundson, A.B. Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody. J.Mol.Recog., 12:19-32, 1999 Cited by PubMed: 10398393 DOI: 10.1002/(SICI)1099-1352(199901/02)12:1<19::AID-JMR445>3.3.CO;2-P PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation