2FBX
| WRN exonuclease, Mg complex | Descriptor: | MAGNESIUM ION, Werner syndrome helicase | Authors: | Perry, J.J. | Deposit date: | 2005-12-10 | Release date: | 2006-04-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
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2FBY
| WRN exonuclease, Eu complex | Descriptor: | EUROPIUM (III) ION, Werner syndrome helicase | Authors: | Perry, J.J. | Deposit date: | 2005-12-10 | Release date: | 2006-04-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
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2FC0
| WRN exonuclease, Mn dGMP complex | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Werner syndrome helicase | Authors: | Perry, J.J, Tainer, J.A. | Deposit date: | 2005-12-10 | Release date: | 2006-04-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
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2FBV
| WRN exonuclease, Mn complex | Descriptor: | MANGANESE (II) ION, Werner syndrome helicase | Authors: | Perry, J.J. | Deposit date: | 2005-12-10 | Release date: | 2006-04-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
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2FBT
| WRN exonuclease | Descriptor: | ACETIC ACID, Werner syndrome helicase | Authors: | Perry, J.J. | Deposit date: | 2005-12-10 | Release date: | 2006-04-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
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3AAF
| Structure of WRN RQC domain bound to double-stranded DNA | Descriptor: | ACETATE ION, DNA (5'-D(*AP*CP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*GP*T)-3'), Werner syndrome ATP-dependent helicase | Authors: | Kitano, K, Hakoshima, T. | Deposit date: | 2009-11-16 | Release date: | 2010-02-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN Structure, 18, 2010
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8PFL
| Crystal structure of WRN helicase domain in complex with 3 | Descriptor: | 2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-7-oxidanylidene-6-[4-(3-oxidanylpyridin-2-yl)carbonylpiperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]-~{N}-[2-methyl-4-(trifluoromethyl)phenyl]ethanamide, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION | Authors: | Scheufler, C, Meyer, M, Moebitz, H. | Deposit date: | 2023-06-16 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A WRN inhibitor shows anti-tumor efficacy in MSI-high tumor models To Be Published, 2024
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8PFO
| Crystal structure of WRN helicase domain in complex with HRO761 | Descriptor: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION, ~{N}-[2-chloranyl-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-6-[4-(6-methyl-5-oxidanyl-pyrimidin-4-yl)carbonylpiperazin-1-yl]-7-oxidanylidene-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]ethanamide | Authors: | Scheufler, C, Meyer, M, Moebitz, H. | Deposit date: | 2023-06-16 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A WRN inhibitor shows anti-tumor efficacy in MSI-high tumor models To Be Published, 2024
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8PFP
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2E1F
| Crystal structure of the HRDC Domain of Human Werner Syndrome Protein, WRN | Descriptor: | CHLORIDE ION, Werner syndrome ATP-dependent helicase | Authors: | Kitano, K, Yoshihara, N, Hakoshima, T. | Deposit date: | 2006-10-25 | Release date: | 2006-12-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the HRDC domain of human Werner syndrome protein, WRN J.Biol.Chem., 282, 2007
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2E1E
| Crystal structure of the HRDC Domain of Human Werner Syndrome Protein, WRN | Descriptor: | CHLORIDE ION, Werner syndrome ATP-dependent helicase | Authors: | Kitano, K, Yoshihara, N, Hakoshima, T. | Deposit date: | 2006-10-25 | Release date: | 2006-12-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the HRDC domain of human Werner syndrome protein, WRN J.Biol.Chem., 282, 2007
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6YHR
| Crystal structure of Werner syndrome helicase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Werner syndrome ATP-dependent helicase, ZINC ION | Authors: | Newman, J.A, Gavard, A.E, Savitsky, P, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2020-03-30 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Life Sci Alliance, 4, 2021
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7XUT
| Crystal structure of RPA70N-WRN fusion | Descriptor: | fusion protein of Replication protein A 70 kDa DNA-binding subunit and Werner syndrome ATP-dependent helicase | Authors: | Wu, Y.Y, Zang, N, Fu, W.M, Zhou, C. | Deposit date: | 2022-05-19 | Release date: | 2023-06-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural characterization of human RPA70N association with DNA damage response proteins. Elife, 12, 2023
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2AXL
| Solution structure of a multifunctional DNA- and protein-binding domain of human Werner syndrome protein | Descriptor: | Werner syndrome | Authors: | Hu, J.-S, Feng, H, Zeng, W, Lin, G.-X, Xi, X.G. | Deposit date: | 2005-09-05 | Release date: | 2005-12-13 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein. Proc.Natl.Acad.Sci.Usa, 102, 2005
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8YLE
| Crystal structure of Werner syndrome helicase complexed with AMP-PCP | Descriptor: | 1,2-ETHANEDIOL, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Yang, Y, Fu, L, Sun, X, Cheng, H, Chen, R. | Deposit date: | 2024-03-06 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure of werner syndrome helicase complexed with AMP-PCP at 1.86 Angstroms resolution. To Be Published
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6TYV
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2E6L
| structure of mouse WRN exonuclease domain | Descriptor: | SULFATE ION, Werner syndrome ATP-dependent helicase homolog, ZINC ION | Authors: | Cho, Y, Choi, J.M. | Deposit date: | 2006-12-27 | Release date: | 2007-01-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | probing the roles of active site residues in 3'-5' exonuclease of werner syndrome protein TO BE PUBLISHED
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6TYW
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6TYZ
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2E6M
| structure of mouse werner exonuclease domain | Descriptor: | SULFATE ION, Werner syndrome ATP-dependent helicase homolog | Authors: | Cho, Y, Choi, J.M. | Deposit date: | 2006-12-27 | Release date: | 2007-01-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | probing the roles of active site residues in 3'-5' exonuclease of werner syndrome protein TO BE PUBLISHED
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6TYX
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6TYU
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6TYT
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2DGZ
| Solution structure of the Helicase and RNase D C-terminal domain in Werner syndrome ATP-dependent helicase | Descriptor: | Werner syndrome protein variant | Authors: | Abe, C, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-03-16 | Release date: | 2006-09-16 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Solution structure of the Helicase and RNase D C-terminal domain in Werner syndrome ATP-dependent helicase To be Published
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2MH9
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