6YHR

Crystal structure of Werner syndrome helicase

Summary for 6YHR

Entry DOI	10.2210/pdb6yhr/pdb
Descriptor	Werner syndrome ATP-dependent helicase, ADENOSINE-5'-DIPHOSPHATE, ZINC ION, ... (4 entities in total)
Functional Keywords	helicase, werners syndrome, dna repair, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	67413.75
Authors	Newman, J.A.,Gavard, A.E.,Savitsky, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-03-30, release date: 2020-04-29, Last modification date: 2024-01-24)
Primary citation	Newman, J.A.,Gavard, A.E.,Lieb, S.,Ravichandran, M.C.,Hauer, K.,Werni, P.,Geist, L.,Bottcher, J.,Engen, J.R.,Rumpel, K.,Samwer, M.,Petronczki, M.,Gileadi, O. Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Life Sci Alliance, 4:-, 2021 Cited by PubMed: 33199508 DOI: 10.26508/lsa.202000795 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation