PDB Search results for query - Protein Data Bank Japan

PDB: 188 results Info pages Status search Chemie search BIRD

Structural basis of WDR5-MLL interaction
Descriptor:	Mixed-lineage leukemia protein 1, SULFATE ION, WD repeat-containing protein 5
Authors:	Song, J.J, Kingston, R.E.
Deposit date:	2008-09-24
Release date:	2008-10-07
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.37 Å)
Cite:	WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket. J.Biol.Chem., 283, 2008

6UHZ

WDR5 in complex with Myc site fragment inhibitor
Descriptor:	1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5
Authors:	Wang, F, Fesik, S.w.
Deposit date:	2019-09-29
Release date:	2020-04-15
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.258 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

6UHY

WDR5 in complex with Myc site fragment inhibitor
Descriptor:	1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5
Authors:	Wang, F, Fesik, S.W.
Deposit date:	2019-09-29
Release date:	2020-04-15
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.26 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

2CNX

WDR5 and Histone H3 Lysine 4 dimethyl complex at 2.1 angstrom
Descriptor:	HISTONE H3 DIMETHYL-LYSINE 4, WD-REPEAT PROTEIN 5
Authors:	Ruthenburg, A.J, Wang, W, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L.
Deposit date:	2006-05-25
Release date:	2006-07-03
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Histone H3 Recognition and Presentation by the Wdr5 Module of the Mll1 Complex Nat.Struct.Mol.Biol., 13, 2006

2CO0

WDR5 and unmodified Histone H3 complex at 2.25 Angstrom
Descriptor:	HISTONE H3 DIMETHYL-LYSINE 4, WD-REPEAT PROTEIN 5
Authors:	Ruthenburg, A.J, Wang, W, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L.
Deposit date:	2006-05-25
Release date:	2006-07-03
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Histone H3 Recognition and Presentation by the Wdr5 Module of the Mll1 Complex Nat.Struct.Mol.Biol., 13, 2006

2H9L

WDR5delta23
Descriptor:	SULFATE ION, WD-repeat protein 5
Authors:	Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:	2006-06-10
Release date:	2006-08-01
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006

5SXM

WDR5 in complex with MLL Win motif peptidomimetic
Descriptor:	ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2, WD repeat-containing protein 5
Authors:	Alicea-Velazquez, N.L, Shinsky, S.A, Cosgrove, M.S.
Deposit date:	2016-08-09
Release date:	2016-09-07
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. J.Biol.Chem., 291, 2016

2O9K

WDR5 in Complex with Dimethylated H3K4 Peptide
Descriptor:	H3 HISTONE, WD repeat protein 5
Authors:	Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:	2006-12-13
Release date:	2006-12-19
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural Basis for Molecular Recognition and Presentation of Histone H3 by Wdr5. Embo J., 25, 2006

5VFC

WDR5 bound to inhibitor MM-589
Descriptor:	1,2-ETHANEDIOL, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ...
Authors:	Stuckey, J.A.
Deposit date:	2017-04-07
Release date:	2017-06-28
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.64 Å)
Cite:	Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J. Med. Chem., 60, 2017

2XL3

WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE
Descriptor:	GLYCEROL, HISTONE H3.1, RETINOBLASTOMA-BINDING PROTEIN 5, ...
Authors:	Odho, Z, Southall, S.M, Wilson, J.R.
Deposit date:	2010-07-19
Release date:	2010-08-04
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1. J.Biol.Chem., 285, 2010

2XL2

WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE
Descriptor:	GLYCEROL, RETINOBLASTOMA-BINDING PROTEIN 5, WD REPEAT-CONTAINING PROTEIN 5
Authors:	Odho, Z, Southall, S.M, Wilson, J.R.
Deposit date:	2010-07-19
Release date:	2010-08-04
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1. J.Biol.Chem., 285, 2010

8HMX

WDR5 in complex with histone H3Q5his peptide
Descriptor:	WD repeat-containing protein 5, histone H3Q5his peptide
Authors:	Li, H.T, Zhao, S, Wang, H.F.
Deposit date:	2022-12-06
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	WDR5 in complex with histone H3Q5his peptide To Be Published

8Q1N

Cyclic peptide binder of the WBM-site of WDR5
Descriptor:	Cyclic peptide inhibitor, WD repeat-containing protein 5
Authors:	Schmeing, S, Chang, J.Y, t Hart, P, Gasper, R.
Deposit date:	2023-08-01
Release date:	2023-09-06
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.843 Å)
Cite:	Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions. Chem.Commun.(Camb.), 59, 2023

8G3C

Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor)
Descriptor:	N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide, WD repeat-containing protein 5
Authors:	Zhao, M.
Deposit date:	2023-02-07
Release date:	2023-06-28
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023

8G3E

Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor)
Descriptor:	(1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5
Authors:	Zhao, M.
Deposit date:	2023-02-07
Release date:	2023-06-28
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.33 Å)
Cite:	Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023

7U9Y

WDR5 bound to 2-(3,5-dimethoxybenzyl)-7-((2-methyl-1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one
Descriptor:	(5P)-2-[(3,5-dimethoxyphenyl)methyl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,4-dihydroisoquinolin-1(2H)-one, BENZAMIDINE, WD repeat-containing protein 5
Authors:	Rietz, T.
Deposit date:	2022-03-11
Release date:	2022-04-27
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022

6PGE

WDR5delta32 bound to ethyl 3-(4-(hydroxymethyl)-1H-imidazol-2-yl)propanoate
Descriptor:	1,2-ETHANEDIOL, SULFATE ION, WD repeat-containing protein 5, ...
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.76 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PGD

WDR5delta32 bound to peptidomimetic
Descriptor:	N-acetyl-L-alanyl-5-[5-(hydroxymethyl)-1H-imidazol-2-yl]-L-norvalyl-L-valinamide, SULFATE ION, WD repeat-containing protein 5
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PGC

WDR5delta32 bound to methyl benzyl(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate
Descriptor:	SULFATE ION, WD repeat-containing protein 5, methyl benzyl{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.81 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PGF

WDR5delta32 bound to N-(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acrylamide
Descriptor:	N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}prop-2-enamide, SULFATE ION, WD repeat-containing protein 5
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.54 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PG7

WDR5delta32 bound to (2-(3-methoxy-3-phenylpropyl)-1H-imidazol-4-yl)methanol
Descriptor:	DI(HYDROXYETHYL)ETHER, WD repeat-containing protein 5, {2-[(3S)-3-methoxy-3-phenylpropyl]-1H-imidazol-4-yl}methanol
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PG6

WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acetamide
Descriptor:	CHLORIDE ION, N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}acetamide, SULFATE ION, ...
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.68 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PG3

WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol
Descriptor:	(2-butyl-1H-imidazol-4-yl)methanol, WD repeat-containing protein 5
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.04 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PGB

WDR5delta32 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)-2-phenylacetamide
Descriptor:	N-{4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}-2-phenylacetamide, SULFATE ION, WD repeat-containing protein 5
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.73 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

6PG5

WDR5delta32 bound to benzyl (4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate
Descriptor:	SULFATE ION, WD repeat-containing protein 5, benzyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate
Authors:	Dennis, M.L, Peat, T.S.
Deposit date:	2019-06-24
Release date:	2019-12-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.99 Å)
Cite:	Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019

12 3 4 5 6 7 8 >

Total results:	188
Displayed results:	25
Sorted by:	Hit score (from highest)
Query:	WDR5