5SXM
WDR5 in complex with MLL Win motif peptidomimetic
Summary for 5SXM
Entry DOI | 10.2210/pdb5sxm/pdb |
Descriptor | WD repeat-containing protein 5, ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2 (3 entities in total) |
Functional Keywords | beta propeller, wd40 repeat, transcription regulator, scaffold, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 70650.01 |
Authors | Alicea-Velazquez, N.L.,Shinsky, S.A.,Cosgrove, M.S. (deposition date: 2016-08-09, release date: 2016-09-07, Last modification date: 2023-10-04) |
Primary citation | Alicea-Velazquez, N.L.,Shinsky, S.A.,Loh, D.M.,Lee, J.H.,Skalnik, D.G.,Cosgrove, M.S. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. J.Biol.Chem., 291:22357-22372, 2016 Cited by PubMed: 27563068DOI: 10.1074/jbc.M116.752626 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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