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8A4I
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BU of 8a4i by Molmil
Crystal structure of SALL4 zinc finger cluster 4 with AT-rich DNA
Descriptor: DNA (5'-D(*GP*AP*TP*AP*TP*TP*AP*AP*TP*AP*TP*C)-3'), MAGNESIUM ION, Sal-like protein 4, ...
Authors:Watson, J.A, Pantier, R, Jayachandran, U, Chhatbar, K, Alexander-Howden, B, Kruusvee, V, Prendecki, M, Bird, A, Cook, A.G.
Deposit date:2022-06-11
Release date:2023-01-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome.
Life Sci Alliance, 6, 2023
6UML
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BU of 6uml by Molmil
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Clayton, T.L, Matyskiela, M.E, Pagarigan, B.E, Tran, E.T, Chamberlain, P.P.
Deposit date:2019-10-09
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Nat.Struct.Mol.Biol., 27, 2020
8U15
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BU of 8u15 by Molmil
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220
Descriptor: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DDB1, Protein cereblon, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8U16
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The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide
Descriptor: 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8U17
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BU of 8u17 by Molmil
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
Descriptor: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
Authors:Seo, H.S, Dhe-Paganon, S.
Deposit date:2022-05-17
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
5XWR
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BU of 5xwr by Molmil
Crystal Structure of RBBP4-peptide complex
Descriptor: Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE
Authors:Jobichen, C, Lui, B.H, Daniel, G.T, Sivaraman, J.
Deposit date:2017-06-30
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7BQV
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Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide
Descriptor: 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione, Protein cereblon, SULFATE ION, ...
Authors:Furihata, H, Miyauchi, Y, Asano, A, Tanokura, M, Miyakawa, T.
Deposit date:2020-03-25
Release date:2020-08-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
Nat Commun, 11, 2020
7BQU
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Cereblon in complex with SALL4 and (S)-thalidomide
Descriptor: Protein cereblon, S-Thalidomide, Sal-like protein 4, ...
Authors:Furihata, H, Miyauchi, Y, Asano, A, Tanokura, M, Miyakawa, T.
Deposit date:2020-03-25
Release date:2020-08-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
Nat Commun, 11, 2020
7Y3I
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Structure of DNA bound SALL4
Descriptor: DNA (12-mer), Sal-like protein 4, ZINC ION
Authors:Ru, W, Xu, C.
Deposit date:2022-06-10
Release date:2022-10-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
7Y3M
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BU of 7y3m by Molmil
Structure of SALL4 ZFC1 bound with 16 bp AT-rich dsDNA
Descriptor: DNA (16-mer), Sal-like protein 4, ZINC ION
Authors:Ru, W, Xu, C.
Deposit date:2022-06-11
Release date:2022-10-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.723 Å)
Cite:Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
7Y3K
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Structure of SALL4 ZFC4 bound with 16 bp AT-rich dsDNA
Descriptor: DNA (16-mer), Sal-like protein 4, ZINC ION
Authors:Ru, W, Xu, C.
Deposit date:2022-06-11
Release date:2022-10-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
7Y3L
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BU of 7y3l by Molmil
Structure of SALL3 ZFC4 bound with 12 bp AT-rich dsDNA
Descriptor: DNA (12-mer), Sal-like protein 3, ZINC ION
Authors:Ru, W, Xu, C.
Deposit date:2022-06-11
Release date:2022-10-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
8OU3
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BU of 8ou3 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 8d
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-fluoranyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Heim, C, Bischof, L, Maiwald, S, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU5
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Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11b
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-(trifluoromethyl)benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU4
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Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11a
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-chloranyl-benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU7
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BU of 8ou7 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11d
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methoxy-benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-22
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU6
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Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11c
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU9
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BU of 8ou9 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11e
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-oxidanyl-benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-22
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OUA
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BU of 8oua by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11f
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(fluoranyl)-3-methoxy-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-22
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023

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PDB entries from 2024-09-18

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