8U17
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide
Summary for 8U17
Entry DOI | 10.2210/pdb8u17/pdb |
Descriptor | Protein cereblon, DNA damage-binding protein 1, Sal-like protein 4, ... (5 entities in total) |
Functional Keywords | complex, glue, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 292950.40 |
Authors | |
Primary citation | Ma, X.,Leon, B.,Ornelas, E.,Dovala, D.,Tandeske, L.,Luu, C.,Pardee, G.,Widger, S.,Solomon, J.M.,Beckwith, R.E.J.,Moser, H.,Clifton, M.C.,Wartchow, C.A. Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13:22088-22088, 2023 Cited by PubMed: 38086859DOI: 10.1038/s41598-023-48606-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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