8U16

The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide

Summary for 8U16

• Entry DOI: 10.2210/pdb8u16/pdb
• Descriptor: Protein cereblon, DNA damage-binding protein 1, Sal-like protein 4, ... (7 entities in total)
• Functional Keywords: complex, glue, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 286473.23

Authors

Clifton, M.C.,Ma, X.,Ornelas, E. (deposition date: 2023-08-30, release date: 2023-12-27)

• Primary citation: Ma, X.,Leon, B.,Ornelas, E.,Dovala, D.,Tandeske, L.,Luu, C.,Pardee, G.,Widger, S.,Solomon, J.M.,Beckwith, R.E.J.,Moser, H.,Clifton, M.C.,Wartchow, C.A.; Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.; Sci Rep, 13:22088-22088, 2023; PubMed: 38086859; DOI: 10.1038/s41598-023-48606-3

Experimental method

X-RAY DIFFRACTION (2.9 Å)