1RP3
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COCRYSTAL STRUCTURE OF THE FLAGELLAR SIGMA/ANTI-SIGMA COMPLEX, SIGMA-28/FLGM
Descriptor:RNA polymerase sigma factor FliA, anti sigma factor FlgM
Authors:Sorenson, M.K., Ray, S.S., Darst, S.A.
Deposit date:2003-12-02
Release date:2004-04-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Flagellar Sigma/Anti-Sigma Complex Sigma(28)/FlgM Reveals an Intact Sigma Factor in an Inactive Conformation
Mol.Cell, 14, 2004
1SC5
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SIGMA-28(FLIA)/FLGM COMPLEX
Descriptor:RNA polymerase sigma factor FliA, anti sigma factor FlgM
Authors:Sorenson, M.K., Ray, S.S., Darst, S.A.
Deposit date:2004-02-11
Release date:2004-04-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.
Mol.Cell, 14, 2004
1TTY
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SOLUTION STRUCTURE OF SIGMA A REGION 4 FROM THERMOTOGA MARITIMA
Descriptor:RNA polymerase sigma factor rpoD
Authors:Lambert, L.J., Wei, Y., Schirf, V., Demeler, B., Werner, M.H.
Deposit date:2004-06-23
Release date:2004-11-23
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:T4 AsiA blocks DNA recognition by remodeling sigma(70) region 4
Embo J., 23, 2004
1TLH
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T4 ASIA BOUND TO SIGMA70 REGION 4
Descriptor:10 kDa anti-sigma factor, RNA polymerase sigma factor rpoD
Authors:Lambert, L.J., Wei, Y., Schirf, V., Demeler, B., Werner, M.H.
Deposit date:2004-06-09
Release date:2004-11-23
Modification date:2014-09-17
Method:SOLUTION NMR
Cite:T4 AsiA blocks DNA recognition by remodeling sigma(70) region 4
Embo J., 23, 2004
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase (alpha, beta, beta', omega and sigma chains) (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2A68
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFABUTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-01
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A69
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFAPENTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6E
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6H
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC STERPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Temiakov, D., Zenkin, N., Vassylyeva, M.N., Perederina, A., Tahirov, T.H., Savkina, M., Zorov, S., Nikiforov, V., Igarashi, N., Matsugaki, N., Wakatsuki, S., Severinov, K., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2BE5
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH INHIBITOR TAGETITOXIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Svetlov, V., Vassylyeva, M.N., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Artsimovitch, I., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-10-22
Release date:2005-11-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3DXJ
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC MYXOPYRONIN
Descriptor:BACTERIAL RNA POLYMERASE ALPHA SUBUNIT; CHAIN A, B, K, L (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA-PRIME SUBUNIT; CHAIN D, N (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE OMEGA SUBUNIT; CHAIN E, O (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE SIGMA SUBUNIT; CHAIN F, P (E.C.2.7.7.6)
Authors:Das, K., Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
3EQL
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Vassylyeva, M.N., Artsimovitch, I.
Deposit date:2008-09-30
Release date:2008-10-28
Modification date:2009-01-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457, 2009
3IYD
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THREE-DIMENSIONAL EM STRUCTURE OF AN INTACT ACTIVATOR-DEPENDENT TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD, Catabolite gene activator/DNA complex
Authors:Hudson, B.P., Quispe, J., Lara, S., Kim, Y., Berman, H., Arnold, E., Ebright, R.H., Lawson, C.L.
Deposit date:2009-08-01
Release date:2009-11-10
Modification date:2016-02-10
Method:ELECTRON MICROSCOPY (19.799999 Å)
Cite:Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
3T72
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PHOB(E)-SIGMA70(4)-(RNAP-BETHA-FLAP-TIP-HELIX)-DNA TRANSCRIPTION ACTIVATION SUB-COMPLEX
Descriptor:Phosphate regulon transcriptional regulatory protein phoB, RNA polymerase sigma factor rpoD, DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6)
Authors:Blanco, A.G., Canals, A., Bernues, J., Sola, M., Coll, M.
Deposit date:2011-07-29
Release date:2011-09-21
Modification date:2012-08-29
Method:X-RAY DIFFRACTION (4.33 Å)
Cite:The Structure of a Transcription Activation Sub-Complex Reveals How Sigma-70 is Recruited to PhoB Promoters
Embo J., 2011
3WOD
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RNA POLYMERASE-GP39 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor, Putative uncharacterized protein
Authors:Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Modification date:2015-03-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes Dev., 28, 2014
4G7H
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7O
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 2 NT OF RNA
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7Z
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 5-BRU AT TEMPLATE-STRAND POSITION +1
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (3.815 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4JK1
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE TETRAPHOSPHATE (PPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta' subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase omega subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase sigma70 subunit
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-10
Modification date:2013-07-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JK2
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE PENTAPHOSPHATE (PPPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta' subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase omega subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase sigma70 subunit
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Modification date:2013-07-17
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JKR
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CRYSTAL STRUCTURE OF E. COLI RNA POLYMERASE IN COMPLEX WITH PPGPP
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Zuo, Y., Wang, Y., Steitz, T.A.
Deposit date:2013-03-11
Release date:2013-05-15
Modification date:2013-10-23
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4KMU
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X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH RIFAMPIN
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN4
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X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH BENZOXAZINORIFAMYCIN-2B
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (3.965 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN7
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X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH BENZOXAZINORIFAMYCIN-2C
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (3.686 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
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