2K6X
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2k6x
AUTOREGULATION OF A GROUP 1 BACTERIAL SIGMA FACTOR INVOLVES THE FORMATION OF A REGION 1.1- INDUCED COMPACTED STRUCTURE
Descriptor:RNA polymerase sigma factor rpoD
Authors:Schwartz, E.C., Shekhtman, A., Dutta, K., Pratt, M.R., Cowburn, D., Darst, S., Muir, T.W.
Deposit date:2008-07-28
Release date:2008-10-28
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1 - Induced Compacted Structure
Chem.Biol., 15, 2008
3IYD
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3iyd
THREE-DIMENSIONAL EM STRUCTURE OF AN INTACT ACTIVATOR-DEPENDENT TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD, Catabolite gene activator/DNA complex
Authors:Hudson, B.P., Quispe, J., Lara, S., Kim, Y., Berman, H., Arnold, E., Ebright, R.H., Lawson, C.L.
Deposit date:2009-08-01
Release date:2009-11-10
Modification date:2011-07-13
Method:ELECTRON MICROSCOPY (19.799999 Å)
Cite:Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
4JK1
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4jk1
X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE TETRAPHOSPHATE (PPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta' subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase omega subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase sigma70 subunit
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-10
Modification date:2013-07-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JK2
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4jk2
X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE PENTAPHOSPHATE (PPPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta' subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase omega subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase sigma70 subunit
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Modification date:2013-07-17
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JKR
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4jkr
CRYSTAL STRUCTURE OF E. COLI RNA POLYMERASE IN COMPLEX WITH PPGPP
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Zuo, Y., Wang, Y., Steitz, T.A.
Deposit date:2013-03-11
Release date:2013-05-15
Modification date:2013-10-23
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4KMU
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4kmu
X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH RIFAMPIN
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN4
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4kn4
X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH BENZOXAZINORIFAMYCIN-2B
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (3.965 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN7
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4kn7
X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH BENZOXAZINORIFAMYCIN-2C
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (3.686 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4LK1
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4lk1
CRYSTAL STRUCTURE ANALYSIS OF THE E.COLI HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Bae, B., Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Modification date:2013-12-18
Method:X-RAY DIFFRACTION (3.8369 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LLG
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4llg
CRYSTAL STRUCTURE ANALYSIS OF THE E.COLI HOLOENZYME/GP2 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD, Bacterial RNA polymerase inhibitor
Authors:Bae, B., Darst, S.A.
Deposit date:2013-07-09
Release date:2013-11-13
Modification date:2013-12-18
Method:X-RAY DIFFRACTION (3.7936 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4MEX
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4mex
CRYSTAL STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH SALINAMIDE A
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Feng, Y., Zhang, Y., Arnold, E., Ebright, R.H.
Deposit date:2013-08-27
Release date:2014-05-21
Modification date:2014-06-25
Method:X-RAY DIFFRACTION (3.902 Å)
Cite:Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
4MEY
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4mey
CRYSTAL STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Feng, Y., Zhang, Y., Arnold, E., Ebright, R.H.
Deposit date:2013-08-27
Release date:2014-05-21
Modification date:2014-06-25
Method:X-RAY DIFFRACTION (3.948 Å)
Cite:Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
4YFK
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4yfk
ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH SQUARAMIDE COMPOUND 8.
Descriptor:Escherichia coli RNA polymerase alpha subunit (RpoA), Escherichia coli RNA polymerase beta subunit (RpoB), Escherichia coli RNA polymerase beta-prime subunit (RpoC), Escherichia coli RNA polymerase omega subunit (RpoZ), Escherichia coli RNA polymerase sigma70 factor (RpoD)
Authors:Molodtsov, V., Fleming, P.R., Eyermann, C.J., Ferguson, A.D., Foulk, M.A., McKinney, D.C., Masse, C.E., Buurman, E.T., Murakami, K.S.
Deposit date:2015-02-25
Release date:2015-03-11
Modification date:2015-04-22
Method:X-RAY DIFFRACTION (3.571 Å)
Cite:X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
4YFN
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4yfn
ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH SQUARAMIDE COMPOUND 14 (N-[3,4-DIOXO-2-(4-{[4-(TRIFLUOROMETHYL)BENZYL]AMINO}PIPERIDIN-1-YL)CYCLOBUT-1-EN-1-YL]-3,5-DIMETHYL-1,2-OXAZOLE-4-SULFONAMIDE)
Descriptor:Escherichia coli RNA polymerase alpha subunit (RpoA), Escherichia coli RNA polymerase beta subunit (RpoB), Escherichia coli RNA polymerase beta-prime subunit (RpoC), Escherichia coli RNA polymerase omega subunit (RpoZ), Escherichia coli RNA polymerase sigma70 factor (RpoA)
Authors:Molodtsov, V., Fleming, P.R., Eyermann, C.J., Ferguson, A.D., Foulk, M.A., McKinney, D.C., Masse, C.E., Buurman, E.T., Murakami, K.S.
Deposit date:2015-02-25
Release date:2015-03-11
Modification date:2015-04-22
Method:X-RAY DIFFRACTION (3.817 Å)
Cite:X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
4YFX
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4yfx
ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH MYXOPYRONIN B
Descriptor:Escherichia coli RNA polymerase alpha subunit (RpoA), Escherichia coli RNA polymerase beta subunit (RpoB), Escherichia coli RNA polymerase beta-prime subunit (RpoC), Escherichia coli RNA polymerase omega subunit (RpoZ), Escherichia coli RNA polymerase sigma70 factor (RpoD)
Authors:Molodtsov, V., Fleming, P.R., Eyermann, C.J., Ferguson, A.D., Foulk, M.A., McKinney, D.C., Masse, C.E., Buurman, E.T., Murakami, K.S.
Deposit date:2015-02-25
Release date:2015-03-11
Modification date:2015-04-22
Method:X-RAY DIFFRACTION (3.844 Å)
Cite:X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
4YG2
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4yg2
X-RAY CRYSTAL STRUCTUR OF ESCHERICHIA COLI RNA POLYMERASE SIGMA70 HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2015-02-25
Release date:2015-03-18
Modification date:2015-04-22
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:X-ray crystal structure of Escherichia coli RNA polymerase sigma70 holoenzyme
J. Biol. Chem., 288, 2013
4YLN
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4yln
E. COLI TRANSCRIPTION INITIATION COMPLEX - 17-BP SPACER AND 4-NT RNA
Descriptor:E. coli RNA Polymerase alpha subunit, E. coli RNA Polymerase beta subunit, E. coli RNA Polymerase beta' subunit, E. coli RNA Polymerase omega subunit, E. coli RNA Polymerase sigma70 factor/DNA Complex
Authors:Zuo, Y., Steitz, T.A.
Deposit date:2015-03-05
Release date:2015-04-22
Modification date:2015-05-20
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
4YLO
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4ylo
E. COLI TRANSCRIPTION INITIATION COMPLEX - 16-BP SPACER AND 4-NT RNA
Descriptor:E. coli RNA Polymerase alpha subunit, E. coli RNA Polymerase beta subunit, E. coli RNA Polymerase beta' subunit, E. coli RNA Polymerase omega subunit, E. coli RNA Polymerase sigma70 subunit/DNA Complex
Authors:Zuo, Y., Steitz, T.A.
Deposit date:2015-03-05
Release date:2015-04-22
Modification date:2015-05-20
Method:X-RAY DIFFRACTION (6 Å)
Cite:Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
4YLP
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4ylp
E. COLI TRANSCRIPTION INITIATION COMPLEX - 16-BP SPACER AND 5-NT RNA
Descriptor:E. coli RNA Polymerase alpha subunit, E. coli RNA Polymerase beta subunit, E. coli RNA Polymerase beta' subunit, E. coli RNA Polymerase omega subunit, E. coli RNA Polymerase sigma70 factor/DNA Complex
Authors:Zuo, Y., Steitz, T.A.
Deposit date:2015-03-05
Release date:2015-04-22
Modification date:2015-05-20
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble.
Mol.Cell, 58, 2015
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