1TZO
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CRYSTAL STRUCTURE OF THE ANTHRAX TOXIN PROTECTIVE ANTIGEN HEPTAMERIC PREPORE
Descriptor:Protective antigen
Authors:Lacy, D.B., Wigelsworth, D.J., Melnyk, R.A., Collier, R.J.
Deposit date:2004-07-10
Release date:2004-08-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation
Proc.Natl.Acad.Sci.USA, 101, 2004
3ETB
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CRYSTAL STRUCTURE OF THE ENGINEERED NEUTRALIZING ANTIBODY M18 COMPLEXED WITH ANTHRAX PROTECTIVE ANTIGEN DOMAIN 4
Descriptor:Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker, Anthrax Protective Antigen
Authors:Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D.
Deposit date:2008-10-07
Release date:2009-04-28
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.
J.Mol.Biol., 387, 2009
3INO
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1.95A RESOLUTION STRUCTURE OF PROTECTIVE ANTIGEN DOMAIN 4
Descriptor:Protective antigen PA-63
Authors:Lovell, S., Williams, A.S., Anbanandam, A., El-Chami, R., Bann, J.G.
Deposit date:2009-08-12
Release date:2009-11-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH
Protein Sci., 18, 2009
3J9C
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CRYOEM SINGLE PARTICLE RECONSTRUCTION OF ANTHRAX TOXIN PROTECTIVE ANTIGEN PORE AT 2.9 ANGSTROM RESOLUTION
Descriptor:Protective antigen PA-63
Authors:Jiang, J., Pentelute, B.L., Collier, R.J., Zhou, Z.H.
Deposit date:2014-12-25
Release date:2015-03-11
Modification date:2015-06-10
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Atomic structure of anthrax protective antigen pore elucidates toxin translocation.
Nature, 521, 2015
1ACC
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ANTHRAX PROTECTIVE ANTIGEN
Descriptor:ANTHRAX PROTECTIVE ANTIGEN
Authors:Petosa, C., Liddington, R.C.
Deposit date:1997-02-05
Release date:1998-02-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the anthrax toxin protective antigen.
Nature, 385, 1997
1T6B
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CRYSTAL STRUCTURE OF B. ANTHRACIS PROTECTIVE ANTIGEN COMPLEXED WITH HUMAN ANTHRAX TOXIN RECEPTOR
Descriptor:Protective Antigen/Anthrax toxin receptor 2
Authors:Santelli, E., Bankston, L.A., Leppla, S.H., Liddington, R.C.
Deposit date:2004-05-05
Release date:2004-07-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a complex between anthrax toxin and its host cell receptor
Nature, 430, 2004
1TZN
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CRYSTAL STRUCTURE OF THE ANTHRAX TOXIN PROTECTIVE ANTIGEN HEPTAMERIC PREPORE BOUND TO THE VWA DOMAIN OF CMG2, AN ANTHRAX TOXIN RECEPTOR
Descriptor:Protective antigen/Anthrax toxin receptor
Authors:Lacy, D.B., Wigelsworth, D.J., Melnyk, R.A., Collier, R.J.
Deposit date:2004-07-10
Release date:2004-08-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation
Proc.Natl.Acad.Sci.USA, 101, 2004
3KWV
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STRUCTURAL BASIS FOR THE UNFOLDING OF ANTHRAX LETHAL FACTOR BY PROTECTIVE ANTIGEN OLIGOMERS
Descriptor:Protective antigen PA-63, Lethal factor (E.C.3.4.24.83)
Authors:Feld, G.K., Kintzer, A.F., Krantz, B.A.
Deposit date:2009-12-01
Release date:2010-11-10
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers.
Nat.Struct.Mol.Biol., 17, 2010
3MHZ
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1.7A STRUCTURE OF 2-FLUOROHISTIDINE LABELED PROTECTIVE ANTIGEN
Descriptor:Protective antigen
Authors:Lovell, S., Battaile, K.P., Wimalasena, D.S., Janowiak, B.E., Miyagi, M., Sun, J., Hajduch, J., Pooput, C., Kirk, K.L., Bann, J.G.
Deposit date:2010-04-09
Release date:2010-08-11
Modification date:2011-01-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation.
Biochemistry, 49, 2010
3Q8A
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CRYSTAL STRUCTURE OF WT PROTECTIVE ANTIGEN (PH 5.5)
Descriptor:Protective antigen
Authors:Rajapaksha, M., Lovell, S., Janowiak, B.E., Andra, K.K., Battaile, K.P., Bann, J.G.
Deposit date:2011-01-06
Release date:2012-01-18
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (3.129 Å)
Cite:pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
Protein Sci., 21, 2012
3Q8B
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CRYSTAL STRUCTURE OF WT PROTECTIVE ANTIGEN (PH 9.0)
Descriptor:Protective antigen
Authors:Lovell, S., Battaile, K.P., Rajapaksha, M., Janowiak, B.E., Andra, K.K., Bann, J.G.
Deposit date:2011-01-06
Release date:2012-02-15
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
Protein Sci., 21, 2012
3Q8C
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CRYSTAL STRUCTURE OF PROTECTIVE ANTIGEN W346F (PH 5.5)
Descriptor:Protective antigen
Authors:Lovell, S., Battaile, K.P., Rajapaksha, M., Janowiak, B.E., Andra, K.K., Bann, J.G.
Deposit date:2011-01-06
Release date:2012-02-15
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
Protein Sci., 21, 2012
3Q8E
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CRYSTAL STRUCTURE OF PROTECTIVE ANTIGEN W346F (PH 8.5)
Descriptor:Protective Antigen
Authors:Lovell, S., Battaile, K.P., Rajapaksha, M., Janowiak, B.E., Andra, K.K., Bann, J.G.
Deposit date:2011-01-06
Release date:2012-02-15
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
Protein Sci., 21, 2012
3Q8F
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CRYSTAL STRUCTURE OF 2-FLUOROHISTINE LABELED PROTECTIVE ANTIGEN (PH 5.8)
Descriptor:Protective antigen
Authors:Lovell, S., Battaile, K.P., Rajapaksha, M., Janowiak, B.E., Andra, K.K., Bann, J.G.
Deposit date:2011-01-06
Release date:2012-02-15
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
Protein Sci., 21, 2012
3TEW
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CRYSTAL STRUCTURE OF ANTHRAX PROTECTIVE ANTIGEN (MEMBRANE INSERTION LOOP DELETED) TO 1.45-A RESOLUTION
Descriptor:Protective antigen
Authors:Feld, G.K., Krantz, B.A.
Deposit date:2011-08-15
Release date:2011-10-26
Modification date:2012-05-23
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Domain flexibility modulates the heterogeneous assembly mechanism of anthrax toxin protective antigen.
J.Mol.Biol., 415, 2012
3TEX
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CRYSTAL STRUCTURE OF ANTHRAX PROTECTIVE ANTIGEN (MEMBRANE INSERTION LOOP DELETED) TO 1.7-A RESOLUTION
Descriptor:Protective antigen
Authors:Feld, G.K., Krantz, B.A.
Deposit date:2011-08-15
Release date:2011-10-26
Modification date:2012-05-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Domain flexibility modulates the heterogeneous assembly mechanism of anthrax toxin protective antigen.
J.Mol.Biol., 415, 2012
3TEY
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CRYSTAL STRUCTURE OF ANTHRAX PROTECTIVE ANTIGEN (MEMBRANE INSERTION LOOP DELETED) MUTANT S337C N664C TO 2.06-A RESOLUTION
Descriptor:Protective antigen
Authors:Feld, G.K., Krantz, B.A.
Deposit date:2011-08-15
Release date:2011-10-26
Modification date:2012-05-23
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Domain flexibility modulates the heterogeneous assembly mechanism of anthrax toxin protective antigen.
J.Mol.Biol., 415, 2012
3TEZ
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CRYSTAL STRUCTURE OF ANTHRAX PROTECTIVE ANTIGEN MUTANT S337C N664C AND DITHIOLACETONE MODIFIED TO 1.8-A RESOLUTION
Descriptor:Protective antigen
Authors:Feld, G.K., Krantz, B.A.
Deposit date:2011-08-15
Release date:2011-10-26
Modification date:2012-05-23
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Domain flexibility modulates the heterogeneous assembly mechanism of anthrax toxin protective antigen.
J.Mol.Biol., 415, 2012
4EE2
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CRYSTAL STRUCTURE OF ANTHRAX PROTECTIVE ANTIGEN K446M MUTANT TO 1.91-A RESOLUTION
Descriptor:Protective antigen
Authors:Kintzer, A.F., Krantz, B.A.
Deposit date:2012-03-28
Release date:2012-10-24
Modification date:2013-09-04
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Anthrax toxin protective antigen integrates poly-gamma-D-glutamate and pH signals to sense the optimal environment for channel formation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4H2A
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CRYSTAL STRUCTURE OF WILD TYPE PROTECTIVE ANTIGEN TO 1.62 A (PH 7.5)
Descriptor:Protective antigen
Authors:Baker, P.J., Sorrell, F.J.
Deposit date:2012-09-12
Release date:2013-09-25
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)
TO BE PUBLISHED
4NAM
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1.7A STRUCTURE OF 5-FLUORO TRYPTOPHAN LABELED PROTECTIVE ANTIGEN (W206Y)
Descriptor:Protective antigen
Authors:Lovell, S., Battaile, K.P., Chadegani, F., Mulangi, V., Miyagi, M., Bann, J.G.
Deposit date:2013-10-22
Release date:2014-01-22
Modification date:2014-12-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:(19)F nuclear magnetic resonance and crystallographic studies of 5-fluorotryptophan-labeled anthrax protective antigen and effects of the receptor on stability.
Biochemistry, 53, 2014
5FR3
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X-RAY CRYSTAL STRUCTURE OF AGGREGATION-RESISTANT PROTECTIVE ANTIGEN OF BACILLUS ANTHRACIS (MUTANT S559L T576E)
Descriptor:PROTECTIVE ANTIGEN
Authors:Ganesan, A., Siekierska, A., Beerten, J., Brams, M., vanDurme, J., DeBaets, G., vanderKant, R., Gallardo, R., Ramakers, M., Langenberg, T., Wilkinson, H., DeSmet, F., Ulens, C., Rousseau, F., Schymkowitz, J.
Deposit date:2015-12-15
Release date:2016-01-27
Method:X-RAY DIFFRACTION (1.935 Å)
Cite:Structural Hot Spots for the Solubility of Globular Proteins
To be Published
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