5A7I
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CRYSTAL STRUCTURE OF INPP5B IN COMPLEX WITH BIPHENYL 3,3',4,4',5,5'- HEXAKISPHOSPHATE
Descriptor:TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE (E.C.3.1.3.36)
Authors:Tresaugues, L., Mills, S.J., Silvander, C., Cozier, G., Potter, B.V.L., Norldund, P.
Deposit date:2015-07-06
Release date:2016-04-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry, 55, 2016
5A7J
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CRYSTAL STRUCTURE OF INPP5B IN COMPLEX WITH BENZENE 1,2,4,5- TETRAKISPHOSPHATE
Descriptor:TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE (E.C.3.1.3.36)
Authors:Tresaugues, L., Mills, S.J., Silvander, C., Cozier, G., Potter, B.V.L., Nordlund, P.
Deposit date:2015-07-06
Release date:2016-04-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry, 55, 2016
5DFF
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HUMAN APE1 PRODUCT COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DFH
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HUMAN APE1 MISMATCH PRODUCT COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DFI
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HUMAN APE1 PHOSPHOROTHIOATE SUBSTRATE COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DFJ
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HUMAN APE1 E96Q/D210N MISMATCH SUBSTRATE COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DG0
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HUMAN APE1 PHOSPHOROTHIOATE SUBSTRATE COMPLEX WITH MN2+
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-27
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
4Z0V
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609
Descriptor:2',5'-phosphodiesterase 12 (E.C.3.1.4.-,3.1.13.4)
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-26
Release date:2015-06-17
Modification date:2015-08-19
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
4Z2B
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609 IN COMPLEX WITH GSK3036342A
Descriptor:2',5'-phosphodiesterase 12 (E.C.3.1.4.-,3.1.13.4)
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-29
Release date:2015-06-17
Modification date:2015-08-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
4ZKF
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 12
Descriptor:2',5'-phosphodiesterase 12 (E.C.3.1.4.-,3.1.13.4)
Authors:Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T.
Deposit date:2015-04-30
Release date:2015-06-17
Modification date:2015-06-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structure of human phosphodiesterase
To Be Published
4RUW
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THE CRYSTAL STRUCTURE OF ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FROM BEUTENBERGIA CAVERNAE DSM 12333
Descriptor:Endonuclease/exonuclease/phosphatase (E.C.3.1.4.-)
Authors:Wu, R., Jedrzejczak, R., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-11-23
Release date:2014-12-24
Method:X-RAY DIFFRACTION (1.281 Å)
Cite:The crystal structure of endonuclease/exonuclease/phosphatase from Beutenbergia cavernae DSM 12333
To be Published
4QH9
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CRYSTAL STRUCTURE OF MN2+ BOUND HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase (E.C.3.1.-.-, 4.2.99.18)
Authors:Chen, Q., He, H., Georgiadis, M.M.
Deposit date:2014-05-27
Release date:2014-11-12
Method:X-RAY DIFFRACTION (2.175 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QHD
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CRYSTAL STRUCTURE OF APO HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase (E.C.3.1.-.-, 4.2.99.18)
Authors:He, H., Chen, Q., Georgiadis, M.M.
Deposit date:2014-05-28
Release date:2014-11-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QHE
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CRYSTAL STRUCTURE OF MG2+ BOUND HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase (E.C.3.1.-.-, 4.2.99.18)
Authors:He, H., Chen, Q., Georgiadis, M.M.
Deposit date:2014-05-28
Release date:2014-11-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4PUQ
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MUS MUSCULUS TDP2 REACTION PRODUCT COMPLEX WITH 5'-PHOSPHORYLATED RNA/DNA, GLYCEROL, AND MG2+
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2014-03-13
Release date:2014-05-14
Modification date:2014-07-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2).
J.Biol.Chem., 289, 2014
4CML
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CRYSTAL STRUCTURE OF INPP5B IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3,4- BISPHOSPHATE
Descriptor:TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5- PHOSPHATASE, ISOFORM 2 (E.C.3.1.3.36)
Authors:Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Flodin, S., Graslund, S., Karlberg, T., Moche, M., Nyman, T., Schuler, H., Silvander, C., Thorsell, A.G., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2014-01-16
Release date:2014-04-16
Modification date:2014-05-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
Structure, 22, 2014
4CMN
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CRYSTAL STRUCTURE OF OCRL IN COMPLEX WITH A PHOSPHATE ION
Descriptor:INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL-1 (E.C.3.1.3.36)
Authors:Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Flodin, S., Graslund, S., Karlberg, T., Nyman, T., Schuler, H., Silvander, C., Thorsell, A.G., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2014-01-16
Release date:2014-04-16
Modification date:2014-05-21
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
Structure, 22, 2014
3W2X
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CRYSTAL STRUCTURE OF DNA URIDINE ENDONUCLEASE MTH212
Descriptor:Exodeoxyribonuclease (E.C.3.1.11.2)
Authors:Tabata, N., Shida, T., Arai, R.
Deposit date:2012-12-06
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of DNA uridine endonuclease Mth212
To be Published
3W2Y
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CRYSTAL STRUCTURE OF DNA URIDINE ENDONUCLEASE MTH212 MUTANT W205S
Descriptor:Exodeoxyribonuclease (E.C.3.1.11.2)
Authors:Tabata, N., Shida, T., Arai, R.
Deposit date:2012-12-06
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of DNA uridine endonuclease Mth212
To be Published
4LND
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CRYSTAL STRUCTURE OF HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE 1 WITH ESSENTIAL MG2+ COFACTOR
Descriptor:DNA-(apurinic or apyrimidinic site) lyase (E.C.4.2.99.18)
Authors:Manvilla, B.A., Pozharski, E., Toth, E.A., Drohat, A.C.
Deposit date:2013-07-11
Release date:2013-11-27
Modification date:2014-01-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor.
Acta Crystallogr.,Sect.D, 69, 2013
4C1R
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BACTEROIDES THETAIOTAOMICRON VPI-5482 MANNOSYL-6-PHOSPHATASE BT3783
Descriptor:MANNOSYL-6-PHOSPHATASE
Authors:Cuskin, F., Lowe, E.C., Zhu, Y., Temple, M., Thompson, A.J., Cartmell, A., Piens, K., Bracke, D., Vervecken, W., Munoz-Munoz, J.L., Suits, M.D.L., Boraston, A.B., Williams, S.J., Davies, G.J., Abbott, W.D., Martens, E.C., Gilbert, H.J.
Deposit date:2013-08-13
Release date:2013-11-13
Modification date:2015-03-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Gut Bacteroidetes Can Utilize Yeast Mannan Through a Selfish Mechanism.
Nature, 517, 2015
3W3D
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CRYSTAL STRUCTURE OF SMOOTH MUSCLE G ACTIN DNASE I COMPLEX
Descriptor:Actin, gamma-enteric smooth muscle, Deoxyribonuclease-1 (E.C.3.1.21.1)
Authors:Sakabe, N., Sakabe, K., Sasaki, K., Kondo, H., Shimomur, M.
Deposit date:2012-12-20
Release date:2013-01-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Refined structure and solvent network of chicken gizzard G-actin DNase 1 complex at 1.8A resolution
Acta Crystallogr.,Sect.A, 49, 1993
4IEM
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HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE (APE1) WITH PRODUCT DNA AND MG2+
Descriptor:DNA-(apurinic or apyrimidinic site) lyase (E.C.3.1.-.-, 4.2.99.18)
Authors:Tsutakawa, S.E., Mol, C.D., Arvai, A.S., Tainer, J.A.
Deposit date:2012-12-13
Release date:2013-01-23
Modification date:2013-04-10
Method:X-RAY DIFFRACTION (2.3936 Å)
Cite:Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes.
J.Biol.Chem., 288, 2013
4AWN
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STRUCTURE OF RECOMBINANT HUMAN DNASE I (RHDNASEI) IN COMPLEX WITH MAGNESIUM AND PHOSPHATE.
Descriptor:DEOXYRIBONUCLEASE-1 (E.C.3.1.21.1)
Authors:Parsiegla, G., Noguere, C., Santell, L., Lazarus, R.A., Bourne, Y.
Deposit date:2012-06-04
Release date:2013-01-09
Modification date:2013-01-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-Like Superfamily.
Biochemistry, 51, 2012
4B8C
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NUCLEASE MODULE OF THE YEAST CCR4-NOT COMPLEX
Descriptor:POLY(A) RIBONUCLEASE POP2 (E.C.3.1.13.4), GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 1, GLUCOSE-REPRESSIBLE ALCOHOL DEHYDROGENASE TRANSCRIPTIONAL EFFECTOR (E.C.3.1.13.4)
Authors:Basquin, J., Conti, E.
Deposit date:2012-08-26
Release date:2012-11-21
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Architecture of the Nuclease Module of the Yeast Ccr4-not Complex: The not1-Caf1-Ccr4 Interaction.
Mol.Cell, 48, 2012
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