5DV2
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CRYSTAL STRUCTURE OF HUMAN CNOT6L IN COMPLEX WITH CYTIDINE-5'-MONOPHOSPHATE
Descriptor:CCR4-NOT transcription complex subunit 6-like (E.C.3.1.13.4)
Authors:Zhang, Q., Bartlam, M.
Deposit date:2015-09-21
Release date:2016-05-18
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural basis for inhibition of the deadenylase activity of human CNOT6L
Febs Lett., 590, 2016
5J3P
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSYL DNA PHOSPHODIESTERASE 2
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)
Authors:Hornyak, P., Pearl, L.H., Caldecott, K.W., Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 2016
5J3S
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSYL DNA PHOSPHODIESTERASE 2 IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)
Authors:Hornyak, P., Pearl, L.H., Caldecott, K.W., Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 2016
5J3Z
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CRYSTAL STRUCTURE OF M2HTDP2-CAT IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)
Authors:Hornyak, P., Pearl, L.H., Caldecott, K.W., Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 2016
5J42
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CRYSTAL STRUCTURE OF M2HTDP2-CAT IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)
Authors:Hornyak, P., Pearl, L.H., Caldecott, K.W., Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 2016
5HT2
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MOUSE TDP2 REACTION PRODUCT (5'-PHOSPHORYLATED DNA)-MG2+ COMPLEX WITH 1-N6-ETHENO-ADENINE
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-), DNA
Authors:Schellenberg, M.J., Vilas, C.K., Williams, R.S.
Deposit date:2016-01-26
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INK
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MOUSE TDP2 REACTION PRODUCT (5'-PHOSPHORYLATED DNA)-ABASIC/THF-MG2+ COMPLEX
Descriptor:Tyrosyl-DNA phosphodiesterase 2/DNA Complex
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2016-03-07
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INL
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MOUSE TDP2 REACTION PRODUCT (5'-PHOSPHORYLATED DNA)-MG2+ COMPLEX WITH DEOXYADENOSINE
Descriptor:Tyrosyl-DNA phosphodiesterase 2/DNA Complex
Authors:Schellenberg, M.J., Vilas, C.K., Williams, R.S.
Deposit date:2016-03-07
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INM
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MOUSE TDP2 PROTEIN, APO STATE WITH VARIABLE DNA-BINDING GRASP CONFORMATIONS
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2016-03-07
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INN
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MOUSE TDP2 D358N PROTEIN, APO STATE WITH INCREASED DISORDER AMONGST VARIABLE DNA-BINDING GRASP CONFORMATIONS
Descriptor:Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)
Authors:Schellenberg, M.J., Appel, C.D., Williams, R.S.
Deposit date:2016-03-07
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INO
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HUMAN TDP2 REACTION PRODUCT (5'-PHOSPHORYLATED DNA)-MG2+ COMPLEX
Descriptor:Tyrosyl-DNA phosphodiesterase 2/DNA Complex
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2016-03-07
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (3.205 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INP
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MOUSE TDP2 REACTION PRODUCT (5'-PHOSPHORYLATED DNA)-MN2+ COMPLEX
Descriptor:Tyrosyl-DNA phosphodiesterase 2/DNA Complex
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2016-03-07
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (1.947 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INQ
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MOUSE TDP2 REACTION PRODUCT (5'-PHOSPHORYLATED DNA)-CA2+ COMPLEX
Descriptor:Tyrosyl-DNA phosphodiesterase 2/DNA Complex
Authors:Schellenberg, M.J., Williams, R.S.
Deposit date:2016-03-07
Release date:2016-04-27
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5J8N
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EXONUCLEASE III HOMOLOGUE MM3148 FROM METHANOSARCINA MAZEI
Descriptor:Exodeoxyribonuclease III (E.C.3.1.11.2)
Authors:Lakomek, K., Dickmanns, A., Ficner, R.
Deposit date:2016-04-08
Release date:2016-04-27
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structure of the archael ExoIII homologue Mm3148 at 1.4 Angstrom
To Be Published
5A7I
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CRYSTAL STRUCTURE OF INPP5B IN COMPLEX WITH BIPHENYL 3,3',4,4',5,5'- HEXAKISPHOSPHATE
Descriptor:TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE (E.C.3.1.3.36)
Authors:Tresaugues, L., Mills, S.J., Silvander, C., Cozier, G., Potter, B.V.L., Norldund, P.
Deposit date:2015-07-06
Release date:2016-04-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry, 55, 2016
5A7J
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CRYSTAL STRUCTURE OF INPP5B IN COMPLEX WITH BENZENE 1,2,4,5- TETRAKISPHOSPHATE
Descriptor:TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE (E.C.3.1.3.36)
Authors:Tresaugues, L., Mills, S.J., Silvander, C., Cozier, G., Potter, B.V.L., Nordlund, P.
Deposit date:2015-07-06
Release date:2016-04-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry, 55, 2016
5DFF
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HUMAN APE1 PRODUCT COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DFH
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HUMAN APE1 MISMATCH PRODUCT COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DFI
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HUMAN APE1 PHOSPHOROTHIOATE SUBSTRATE COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DFJ
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HUMAN APE1 E96Q/D210N MISMATCH SUBSTRATE COMPLEX
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-26
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
5DG0
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HUMAN APE1 PHOSPHOROTHIOATE SUBSTRATE COMPLEX WITH MN2+
Descriptor:DNA-(apurinic or apyrimidinic site) lyase/DNA Complex
Authors:Freudenthal, B.D., Wilson, S.H.
Deposit date:2015-08-27
Release date:2015-10-14
Modification date:2015-12-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Capturing snapshots of APE1 processing DNA damage.
Nat.Struct.Mol.Biol., 22, 2015
4Z0V
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609
Descriptor:2',5'-phosphodiesterase 12 (E.C.3.1.4.-,3.1.13.4)
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-26
Release date:2015-06-17
Modification date:2015-08-19
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
4Z2B
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609 IN COMPLEX WITH GSK3036342A
Descriptor:2',5'-phosphodiesterase 12 (E.C.3.1.4.-,3.1.13.4)
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-29
Release date:2015-06-17
Modification date:2015-08-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
4ZKF
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 12
Descriptor:2',5'-phosphodiesterase 12 (E.C.3.1.4.-,3.1.13.4)
Authors:Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T.
Deposit date:2015-04-30
Release date:2015-06-17
Modification date:2015-06-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structure of human phosphodiesterase
To Be Published
4RUW
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THE CRYSTAL STRUCTURE OF ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FROM BEUTENBERGIA CAVERNAE DSM 12333
Descriptor:Endonuclease/exonuclease/phosphatase (E.C.3.1.4.-)
Authors:Wu, R., Jedrzejczak, R., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-11-23
Release date:2014-12-24
Method:X-RAY DIFFRACTION (1.281 Å)
Cite:The crystal structure of endonuclease/exonuclease/phosphatase from Beutenbergia cavernae DSM 12333
To be Published
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