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9GBV
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BU of 9gbv by Molmil
E.coli gyrase holocomplex with chirally wrapped 217 bp DNA fragment
Descriptor: DNA gyrase subunit A, DNA gyrase subunit B, MAGNESIUM ION, ...
Authors:Michalczyk, E, Ghilarov, D.
Deposit date:2024-07-31
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.32 Å)
Cite:Structure of Escherichia coli DNA gyrase with chirally wrapped DNA supports ratchet-and-pawl mechanism for an ATP-powered supercoiling motor
Proceedings of the National Academy of Sciences USA, 2024
9EUY
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BU of 9euy by Molmil
Cryo-EM structure of the full-length Pseudomonas aeruginosa bacteriophytochrome in its Pfr state
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome
Authors:Bodizs, S, Westenhoff, S.
Deposit date:2024-03-28
Release date:2024-09-04
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism.
Structure, 2024
9EUT
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BU of 9eut by Molmil
Cryo-EM structure of the full-length Pseudomonas aeruginosa bacteriophytochrome in its Pr state
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome
Authors:Bodizs, S, Westenhoff, S.
Deposit date:2024-03-28
Release date:2024-09-04
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism.
Structure, 2024
8ZM2
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BU of 8zm2 by Molmil
Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16
Descriptor: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, methyl (9~{R})-9-oxidanyl-9-(trifluoromethyl)fluorene-4-carboxylate
Authors:Akai, S, Orita, T, Nomura, A, Adachi, T.
Deposit date:2024-05-22
Release date:2024-06-19
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase.
Bioorg.Med.Chem.Lett., 109, 2024
8ZM1
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BU of 8zm1 by Molmil
Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 6
Descriptor: (5~{R})-5-propan-2-ylindeno[1,2-b]pyridin-5-ol, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Authors:Akai, S, Orita, T, Nomura, A, Adachi, T.
Deposit date:2024-05-22
Release date:2024-06-19
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase.
Bioorg.Med.Chem.Lett., 109, 2024
8U8Z
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BU of 8u8z by Molmil
Cryo-EM structure of PsBphP in Pr state, extended DHp
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, histidine kinase
Authors:Basore, K, Burgie, E.S, Vierstra, D.
Deposit date:2023-09-18
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor.
Nat Commun, 15, 2024
8U65
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BU of 8u65 by Molmil
Cryo-EM structure of PsBphP in Pfr state, splayed PSM only
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, histidine kinase
Authors:Basore, K, Burgie, E.S, Vierstra, D.
Deposit date:2023-09-13
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor.
Nat Commun, 15, 2024
8U64
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BU of 8u64 by Molmil
Cryo-EM structure of PsBphP in Pfr state, medial PSM only
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, histidine kinase
Authors:Basore, K, Burgie, E.S, Vierstra, D.
Deposit date:2023-09-13
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor.
Nat Commun, 15, 2024
8U63
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BU of 8u63 by Molmil
Cryo-EM structure of PsBphP in Pfr state, Dimer of Dimers PSM only
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, histidine kinase
Authors:Basore, K, Burgie, E.S, Vierstra, D.
Deposit date:2023-09-13
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor.
Nat Commun, 15, 2024
8U62
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BU of 8u62 by Molmil
Cryo-EM structure of PsBphP in Pfr state, Dimer of Dimers FL
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, histidine kinase
Authors:Basore, K, Burgie, E.S, Vierstra, D.
Deposit date:2023-09-13
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor.
Nat Commun, 15, 2024
8U4X
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BU of 8u4x by Molmil
Cryo-EM structure of PsBphP in Pr state
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, histidine kinase
Authors:Basore, K, Burgie, E.S, Vierstra, D.
Deposit date:2023-09-11
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor.
Nat Commun, 15, 2024
8SGK
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BU of 8sgk by Molmil
CryoEM structure of Deinococcus radiodurans BphP photosensory module in Pr state
Descriptor: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome
Authors:Li, H, Li, H.
Deposit date:2023-04-12
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:CryoEM structure of Deinococcus radiodurans BphP photosensory module in Pr state
To Be Published
8SBM
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BU of 8sbm by Molmil
Crystal structure of the wild-type Catalytic ATP-binding domain of Mtb DosS
Descriptor: 1,2-ETHANEDIOL, GAF domain-containing protein, SODIUM ION, ...
Authors:Larson, G, Shi, K, Aihara, H, Bhagi-Damodaran, A.
Deposit date:2023-04-03
Release date:2023-11-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Understanding ATP Binding to DosS Catalytic Domain with a Short ATP-Lid.
Biochemistry, 62, 2023
8QQU
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BU of 8qqu by Molmil
Asymetric subunit of E. coli DNA gyrase bound to a linear part of a DNA minicircle
Descriptor: DNA (16-MER), DNA gyrase subunit A, DNA gyrase subunit B
Authors:Vayssieres, M, Lamour, V.
Deposit date:2023-10-06
Release date:2024-04-10
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of DNA crossover capture by Escherichia coli DNA gyrase.
Science, 384, 2024
8QQS
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BU of 8qqs by Molmil
E. coli DNA gyrase bound to a linear part of a DNA minicircle
Descriptor: DNA (30-MER), DNA gyrase subunit A, DNA gyrase subunit B
Authors:Vayssieres, M, Lamour, V.
Deposit date:2023-10-06
Release date:2024-04-10
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of DNA crossover capture by Escherichia coli DNA gyrase.
Science, 384, 2024
8QQI
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BU of 8qqi by Molmil
E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800
Descriptor: DNA gyrase subunit A, DNA gyrase subunit B, MAGNESIUM ION, ...
Authors:Ghilarov, D, Martin, N.I, van der Stelt, M.
Deposit date:2023-10-04
Release date:2024-06-19
Last modified:2024-09-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria.
Nat.Chem., 16, 2024
8QDX
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BU of 8qdx by Molmil
E. coli DNA gyrase bound to a DNA crossover
Descriptor: DNA gyrase subunit A, DNA gyrase subunit B, DNA minicircle
Authors:Vayssieres, M, Lamour, V.
Deposit date:2023-08-30
Release date:2024-04-10
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of DNA crossover capture by Escherichia coli DNA gyrase.
Science, 384, 2024
8PF2
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BU of 8pf2 by Molmil
Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK16
Descriptor: Chemotaxis protein CheA, RESORCINOL
Authors:Adhav, A, Marina, A.
Deposit date:2023-06-15
Release date:2024-06-26
Last modified:2024-08-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity.
Microbiol Spectr, 12, 2024
8P59
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BU of 8p59 by Molmil
Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-333
Descriptor: 7-(2-phenylethoxy)quinazolin-2-amine, Chemotaxis protein CheA
Authors:Adhav, A, Marina, A.
Deposit date:2023-05-23
Release date:2024-06-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-333
To Be Published
8P3R
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BU of 8p3r by Molmil
Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK4
Descriptor: 9~{H}-purine, Chemotaxis protein CheA
Authors:Adhav, A, Marina, A.
Deposit date:2023-05-18
Release date:2024-06-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK4
To Be Published
8P3N
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BU of 8p3n by Molmil
Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK8
Descriptor: 9-METHYL-9H-PURIN-6-AMINE, Chemotaxis protein CheA
Authors:Adhav, A, Marina, A.
Deposit date:2023-05-18
Release date:2024-06-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK8
To Be Published
8OZ9
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BU of 8oz9 by Molmil
Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-383
Descriptor: 7-(1~{H}-1,2,3-triazol-5-yl)quinazolin-2-amine, Chemotaxis protein CheA
Authors:Adhav, A, Marina, A.
Deposit date:2023-05-08
Release date:2024-05-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-383
To Be Published
8OYZ
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BU of 8oyz by Molmil
Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK10
Descriptor: 2-azanyl-7,8-dihydro-6~{H}-quinazolin-5-one, Chemotaxis protein CheA
Authors:Adhav, A, Marina, A.
Deposit date:2023-05-05
Release date:2024-05-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK10
To Be Published
8OYQ
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BU of 8oyq by Molmil
Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK13
Descriptor: Chemotaxis protein CheA, quinazolin-2-amine
Authors:Adhav, A, Marina, A.
Deposit date:2023-05-05
Release date:2024-05-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK13
To Be Published
8ISK
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BU of 8isk by Molmil
Pr conformer of Zea mays phytochrome A1 - ZmphyA1-Pr
Descriptor: 3-[5-[[(3~{R},4~{R})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, Phytochrome
Authors:Zhang, Y, Ma, C, Zhao, J, Gao, N, Wang, J.
Deposit date:2023-03-20
Release date:2023-08-09
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural insights into plant phytochrome A as a highly sensitized photoreceptor.
Cell Res., 33, 2023

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PDB entries from 2024-09-18

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