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1HTY
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1hty
GOLGI ALPHA-MANNOSIDASE II
Descriptor:ALPHA-MANNOSIDASE II (E.C.3.2.1.114)
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-02
Release date:2002-01-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HWW
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1hww
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE
Descriptor:ALPHA-MANNOSIDASE II (E.C.3.2.1.114)
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-10
Release date:2002-01-10
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HXK
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1hxk
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN
Descriptor:ALPHA-MANNOSIDASE II (E.C.3.2.1.114)
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-16
Release date:2002-01-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1O7D
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1o7d
THE STRUCTURE OF THE BOVINE LYSOSOMAL A-MANNOSIDASE SUGGESTS A NOVEL MECHANISM FOR LOW PH ACTIVATION
Descriptor:LYSOSOMAL ALPHA-MANNOSIDASE (E.C.3.2.1.24)
Authors:Heikinheimo, P., Helland, R., Leiros, H.S., Leiros, I., Karlsen, S., Evjen, G., Ravelli, R., Schoehn, G., Ruigrok, R., Tollersrud, O.-K., Mcsweeney, S., Hough, E.
Deposit date:2002-10-30
Release date:2003-03-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of Bovine Lysosomal Alpha-Mannosidase Suggests a Novel Mechanism for Low-Ph Activation
J.Mol.Biol., 327, 2003
1PS3
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1ps3
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH KIFUNENSINE
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Shah, N., Kuntz, D.A., Rose, D.R.
Deposit date:2003-06-20
Release date:2003-12-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms
Biochemistry, 42, 2003
1QWN
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1qwn
GOLGI ALPHA-MANNOSIDASE II COVALENT INTERMEDIATE COMPLEX WITH 5-FLUORO-GULOSYL-FLUORIDE
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R.
Deposit date:2003-09-02
Release date:2003-10-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1QWU
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1qwu
GOLGI ALPHA-MANNOSIDASE II D341N MUTANT COMPLEX WITH 5-F-GULOSIDE
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R.
Deposit date:2003-09-03
Release date:2003-10-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1QX1
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1qx1
GOLGI ALPHA-MANNOSIDASE II D341N MUTANT COMPLEX WITH 2-F-MANNOSYL-F
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R.
Deposit date:2003-09-04
Release date:2003-10-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1R33
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1r33
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH 5-THIO-D-MANNOPYRANOSYLAMINE
Descriptor:putative golgi alpha-mannosidase II, 5-THIO-A/B-D-MANNOPYRANOSYLAMINE
Authors:Kuntz, D.A., Xin, W., Kavelekar, L.M., Rose, D.R., Pinto, B.M.
Deposit date:2003-09-30
Release date:2004-11-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling
TETRAHEDRON ASYMMETRY, 16, 2005
1R34
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1r34
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH 5-THIO-D-MANNOPYRANOSYLAMIDINIUM SALT
Descriptor:putative golgi alpha-mannosidase II, N-(1-IMINIO-2-PHENYLETHYL)-5-THIOHEXOPYRANOSYLAMINE BROMIDE
Authors:Kuntz, D.A., Xin, W., Kavelekar, L.M., Rose, D.R., Pinto, B.M.
Deposit date:2003-09-30
Release date:2004-11-02
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling
TETRAHEDRON ASYMMETRY, 16, 2005
1TQS
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1tqs
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SALACINOL
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQT
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1tqt
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH A DIASTEREOMER OF SALACINOL
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQU
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1tqu
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH THE SALACINOL ANALOG GHAVAMIOL
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQV
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1tqv
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SELENO-SALACINOL (BLINTOL)
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-02-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
TETRAHEDRON ASYMMETRY, 16, 2005
1TQW
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1tqw
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH A DIASTEREOMER OF SELENO-SALACINOL
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-02-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Insights into the Mechanism of Drosophila melanogaster Golgi a-Mannosidase II Through Crystallographic Analysis of the Interactions with Analogues of the Naturally Occurring Glycomimetic Salacinol
TETRAHEDRON ASYMMETRY, 16, 2005
2ALW
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2alw
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH NOEUROMYCIN
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Bols, M.B., Liu, H., Rose, D.R.
Deposit date:2005-08-08
Release date:2006-07-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The role of the active site Zn in the catalytic mechanism of the GH38 Golgi alpha-mannosidase II: implications from noeuromycin inhibition
Biocatal.Biotransfor., 34, 2006
2F18
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2f18
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL
Descriptor:Alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F1A
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2f1a
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S)-2-({[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL
Descriptor:alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F1B
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2f1b
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S,5R)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)-5-METHYLPYRROLIDINE-3,4-DIOL
Descriptor:alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F7O
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2f7o
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH MANNOSTATIN A
Descriptor:alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-07-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions.
J.Am.Chem.Soc., 128, 2006
2F7P
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2f7p
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH BENZYL-MANNOSTATIN A
Descriptor:alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-07-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions.
J.Am.Chem.Soc., 128, 2006
2F7Q
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2f7q
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH AMINOCYCLOPENTITETROL
Descriptor:alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-12-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Golgi alpha-mannosidase II complex with aminocyclopentitetrol
To be Published
2F7R
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2f7r
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH BENZYL-AMINOCYCLOPENTITETROL
Descriptor:alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-12-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol
To be Published
2FYV
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2fyv
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH AN AMINO-SALACINOL CARBOXYLATE ANALOG
Descriptor:putative golgi alpha-mannosidase II (E.C.3.2.1.114)
Authors:Kuntz, D.A, Hamlet, T., Rose, D.R.
Deposit date:2006-02-08
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids.
Bioorg.Med.Chem., 14, 2006
2OW6
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2ow6
GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (1R,5S,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-5,7,8-TRIOL CHLORIDE
Descriptor:PROTEIN
Authors:Kuntz, D.A.
Deposit date:2007-02-15
Release date:2008-01-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: The role of water in inhibitor binding.
Proteins, 71, 2008
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entries available on 2014-11-26
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