2DKO
| Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis | Descriptor: | Caspase-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | Authors: | Mittl, P.R.E, Ganesan, R, Jelakovic, S, Grutter, M.G. | Deposit date: | 2006-04-12 | Release date: | 2006-07-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-ray Structure Analysis J.Mol.Biol., 359, 2006
|
|
4JJ7
| |
1QTN
| |
2J32
| The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of(Pro)caspase-3 | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CASPASE-3 | Authors: | Feeney, B, Pop, C, Swartz, P, Mattos, C, Clark, A.C. | Deposit date: | 2006-08-17 | Release date: | 2006-11-08 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3. Biochemistry, 45, 2006
|
|
5IBP
| Caspase 3 V266M | Descriptor: | ACE-ASP-GLU-VAL-ASK, AZIDE ION, Caspase-3 | Authors: | Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. | Deposit date: | 2016-02-22 | Release date: | 2016-10-26 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
4AF8
| The structural basis for metacaspase substrate specificity and activation | Descriptor: | CHLORIDE ION, METACASPASE MCA2, SODIUM ION | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | Deposit date: | 2012-01-18 | Release date: | 2012-05-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
2J30
| The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)caspase-3 | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CASPASE-3 | Authors: | Feeney, B, Pop, C, Swartz, P, Mattos, C, Clark, A.C. | Deposit date: | 2006-08-17 | Release date: | 2006-11-08 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3. Biochemistry, 45, 2006
|
|
8WRA
| The Crystal Structure of CASP1 from Biortus | Descriptor: | 1,2-ETHANEDIOL, Caspase-1 | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. | Deposit date: | 2023-10-13 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Crystal Structure of CASP1 from Biortus. To Be Published
|
|
6X8H
| Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct | Descriptor: | Ac-DW3-KE, Caspase-8 | Authors: | Solania, A, Xu, J.H, Wolan, D.W. | Deposit date: | 2020-06-01 | Release date: | 2021-06-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct To Be Published
|
|
4JJE
| |
4QUJ
| Caspase-3 T140GV266H | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, ... | Authors: | Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. | Deposit date: | 2014-07-10 | Release date: | 2014-11-05 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.498 Å) | Cite: | Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
|
|
6CL0
| |
6CKZ
| |
3PCX
| Caspase-3 E246A, K242A Double Mutant | Descriptor: | Caspase-3, Inhibitor Ac-DEVD-CMK | Authors: | Walters, J, Swartz, P, Mattos, C, Clark, A.C. | Deposit date: | 2010-10-22 | Release date: | 2011-02-23 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch.Biochem.Biophys., 508, 2011
|
|
2J31
| The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of(Pro)caspase-3 | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CASPASE-3 | Authors: | Feeney, B, Pop, C, Swartz, P, Mattos, C, Clark, A.C. | Deposit date: | 2006-08-17 | Release date: | 2006-11-08 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3. Biochemistry, 45, 2006
|
|
4AFV
| THE STRUCTURE OF METACASPASE 2 FROM T. BRUCEI DETERMINED IN THE PRESENCE OF CALCIUM CHLORIDE | Descriptor: | METACASPASE MCA2 | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | Deposit date: | 2012-01-23 | Release date: | 2012-05-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
6X8I
| |
2XYG
| Caspase-3:CAS329306 | Descriptor: | CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide | Authors: | Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. | Deposit date: | 2010-11-17 | Release date: | 2011-08-17 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011
|
|
5IAS
| Caspase 3 V266Y | Descriptor: | ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION | Authors: | Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. | Deposit date: | 2016-02-21 | Release date: | 2016-10-26 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
6BFO
| Caspase-3 Mutant- T245D | Descriptor: | AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3, ... | Authors: | Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. | Deposit date: | 2017-10-26 | Release date: | 2018-02-21 | Last modified: | 2018-04-25 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
|
|
6BFJ
| Caspase-3 Mutant - T245D,S249D | Descriptor: | AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, Caspase-3 | Authors: | Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. | Deposit date: | 2017-10-26 | Release date: | 2018-02-21 | Last modified: | 2018-04-25 | Method: | X-RAY DIFFRACTION (1.543 Å) | Cite: | Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
|
|
5IAE
| Caspase 3 V266F | Descriptor: | ACE-ASP-GLU-VAL-ASK, ACETATE ION, CHLORIDE ION, ... | Authors: | Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. | Deposit date: | 2016-02-21 | Release date: | 2016-10-26 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
4QU9
| Caspase-3 F128A | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3 | Authors: | Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. | Deposit date: | 2014-07-10 | Release date: | 2014-11-05 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.561 Å) | Cite: | Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
|
|
5IAJ
| Caspase 3 V266L | Descriptor: | ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION | Authors: | Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. | Deposit date: | 2016-02-21 | Release date: | 2016-10-26 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
4EHD
| Allosteric Modulation of Caspase-3 through Mutagenesis | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | Authors: | Walters, J, Schipper, J.L, Swartz, P, Mattos, C, Clark, A.C. | Deposit date: | 2012-04-02 | Release date: | 2012-06-06 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.581 Å) | Cite: | Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
|
|