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6T6E
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BU of 6t6e by Molmil
Crystal Structure of the C-terminal domain of the HIV-1 Integrase (PNL4-3)
Descriptor: NICKEL (II) ION, Pol protein
Authors:Ruff, M, Negroni, M.
Deposit date:2019-10-18
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.302 Å)
Cite:NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
J.Virol., 94, 2020
5D7U
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BU of 5d7u by Molmil
Crystal structure of the C-terminal domain of MMTV integrase
Descriptor: ISOPROPYL ALCOHOL, Pr160
Authors:Cook, N.J, Pye, V.E, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-08-14
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
6TJU
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BU of 6tju by Molmil
X-ray structure of C-terminal domain of human T-cell lymphotropic virus type 1 (HTLV-1)
Descriptor: Pol protein
Authors:Barski, M, Maertens, G.N.
Deposit date:2019-11-26
Release date:2020-10-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56 gamma.
Nat Commun, 11, 2020
5TC2
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BU of 5tc2 by Molmil
C-terminal domain of HIV-1 integrase, crystal structure
Descriptor: GLYCEROL, integrase
Authors:Tsirkone, V.G, Strelkov, S.V.
Deposit date:2016-09-14
Release date:2018-04-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Interaction of TRN-SR2 with HIV Integrase
To Be Published
4FW1
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BU of 4fw1 by Molmil
Crystal structure of two-domain RSV INTEGRASE covalently linked with DNA
Descriptor: Integrase
Authors:Shi, K, Aihara, H.
Deposit date:2012-06-29
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding.
Plos One, 8, 2013
6T6J
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BU of 6t6j by Molmil
Crystal Structure of the C-terminal domain of the HIV-1 Integrase (subtype A2, mutant N254K, K340Q)
Descriptor: NICKEL (II) ION, Pol protein
Authors:Ruff, M, Negroni, M.
Deposit date:2019-10-18
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
J.Virol., 94, 2020
9C9M
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BU of 9c9m by Molmil
HIV-1 intasome core bound with DTG
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ...
Authors:Li, M, Craigie, R.
Deposit date:2024-06-14
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (2.01 Å)
Cite:HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration.
Viruses, 16, 2024
8T5B
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BU of 8t5b by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor EKC-110
Descriptor: (2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, Integrase, MAGNESIUM ION
Authors:Dinh, T, Kvaratskhelia, M.
Deposit date:2023-06-12
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Understanding the resistance of Y99H and A128T mutations in HIV-1 Integrase against the effective anti-HIV drugs of STP0404 and BKC11
To Be Published
8FNG
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BU of 8fng by Molmil
Structure of E138K HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-27
Release date:2023-08-09
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
8FNP
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BU of 8fnp by Molmil
Structure of E138K/G140S/Q148H HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-28
Release date:2023-08-09
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
6T6I
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BU of 6t6i by Molmil
Crystal Structure of the C-terminal domain of the HIV-1 Integrase (subtype A2)
Descriptor: NICKEL (II) ION, Pol protein
Authors:Ruff, M, Negroni, M.
Deposit date:2019-10-18
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
J.Virol., 94, 2020
8FNJ
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BU of 8fnj by Molmil
Structure of E138K/G140A HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-27
Release date:2023-08-09
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
8FNH
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BU of 8fnh by Molmil
Structure of Q148K HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-27
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
8FNO
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BU of 8fno by Molmil
Structure of E138K/G140A/Q148R HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-28
Release date:2023-08-09
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
1C0M
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BU of 1c0m by Molmil
CRYSTAL STRUCTURE OF RSV TWO-DOMAIN INTEGRASE
Descriptor: PROTEIN (INTEGRASE)
Authors:Yang, Z.-N, Mueser, T.C, Bushman, F.D, Hyde, C.C.
Deposit date:1999-07-16
Release date:2000-03-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase.
J.Mol.Biol., 296, 2000
4FW2
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BU of 4fw2 by Molmil
Crystal structure of RSV three-domain integrase with disordered N-terminal domain
Descriptor: Integrase
Authors:Shi, K, Aihara, H.
Deposit date:2012-06-29
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding.
Plos One, 8, 2013
8FNN
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BU of 8fnn by Molmil
Structure of E138K/G140A/Q148K HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-27
Release date:2023-08-09
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
6PUZ
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BU of 6puz by Molmil
Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ446 (compound 4f)
Descriptor: 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ...
Authors:Lyumkis, D, Jozwik, I.K, Passos, D.
Deposit date:2019-07-18
Release date:2020-02-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for strand-transfer inhibitor binding to HIV intasomes.
Science, 367, 2020
6PUY
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BU of 6puy by Molmil
Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ426 (compound 4d)
Descriptor: 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ...
Authors:Lyumkis, D, Jozwik, I.K, Passos, D.
Deposit date:2019-07-18
Release date:2020-02-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for strand-transfer inhibitor binding to HIV intasomes.
Science, 367, 2020
8FNM
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BU of 8fnm by Molmil
Structure of G140A/Q148K HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-27
Release date:2023-08-09
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
8FNQ
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BU of 8fnq by Molmil
Structure of E138K/G140A/Q148K HIV-1 intasome with 4d bound
Descriptor: 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-28
Release date:2023-08-09
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
8FN7
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BU of 8fn7 by Molmil
Structure of WT HIV-1 intasome bound to Dolutegravir
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-27
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
8FNL
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BU of 8fnl by Molmil
Structure of E138K/Q148K HIV-1 intasome with Dolutegravir bound
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
Authors:Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
Deposit date:2022-12-27
Release date:2023-08-09
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Sci Adv, 9, 2023
1EX4
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BU of 1ex4 by Molmil
HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, INTEGRASE
Authors:Chen, J.C.-H, Krucinski, J, Miercke, L.J.W, Finer-Moore, J.S, Tang, A.H, Leavitt, A.D, Stroud, R.M.
Deposit date:2000-04-28
Release date:2000-06-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
Proc.Natl.Acad.Sci.USA, 97, 2000
6RWM
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BU of 6rwm by Molmil
SIVrcm intasome in complex with bictegravir
Descriptor: Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020

 

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