1EX4

HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN

Summary for 1EX4

• Entry DOI: 10.2210/pdb1ex4/pdb
• Descriptor: INTEGRASE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE (3 entities in total)
• Functional Keywords: sh3-like domain, nonspecific dna binding beta sheet, cis-proline, viral protein
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• Total number of polymer chains: 2
• Total formula weight: 55313.53

Authors

Chen, J.C.-H.,Krucinski, J.,Miercke, L.J.W.,Finer-Moore, J.S.,Tang, A.H.,Leavitt, A.D.,Stroud, R.M. (deposition date: 2000-04-28, release date: 2000-06-07, Last modification date: 2024-02-07)

• Primary citation: Chen, J.C.,Krucinski, J.,Miercke, L.J.,Finer-Moore, J.S.,Tang, A.H.,Leavitt, A.D.,Stroud, R.M.; Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.; Proc.Natl.Acad.Sci.USA, 97:8233-8238, 2000; PubMed: 10890912; DOI: 10.1073/pnas.150220297

Experimental method

X-RAY DIFFRACTION (2.8 Å)