8FNJ

Structure of E138K/G140A HIV-1 intasome with Dolutegravir bound

Summary for 8FNJ

• Entry DOI: 10.2210/pdb8fnj/pdb
• Related: 8FN7
• EMDB information: 29307 29315
• Descriptor: Lamina-associated polypeptide 2, isoform alpha,Integrase chimera, DNA (27-MER), DNA (25-MER), ... (7 entities in total)
• Functional Keywords: integrase, nucleoprotein complex, inhibitor, drug resistance, viral protein-dna-inhibitor complex, viral protein/dna/inhibitor
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 352288.98

Authors

Shan, Z.L.,Passos, D.O.,Strutzenberg, T.S.,Li, M.,Lyumkis, D. (deposition date: 2022-12-27, release date: 2023-08-09)

• Primary citation: Li, M.,Oliveira Passos, D.,Shan, Z.,Smith, S.J.,Sun, Q.,Biswas, A.,Choudhuri, I.,Strutzenberg, T.S.,Haldane, A.,Deng, N.,Li, Z.,Zhao, X.Z.,Briganti, L.,Kvaratskhelia, M.,Burke Jr., T.R.,Levy, R.M.,Hughes, S.H.,Craigie, R.,Lyumkis, D.; Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.; Sci Adv, 9:eadg5953-eadg5953, 2023; PubMed: 37478179; DOI: 10.1126/sciadv.adg5953

Experimental method

ELECTRON MICROSCOPY (2.4 Å)