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4HND
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4hnd
CRYSTAL STUCTURE OF THE CATALYTIC DOMAIN OF SELENOMETHIONINE SUBSTITUTED HUMAN PI4KIIALPHA IN COMPLEX WITH ADP
Descriptor:Phosphatidylinositol 4-kinase type 2-alpha (E.C.2.7.1.67)
Authors:Zhou, Q., Zhai, Y., Zhang, K., Chen, C., Sun, F.
Deposit date:2012-10-19
Release date:2014-04-09
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
4HNE
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4hne
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYPE II ALPHA PHOSPHATIDYLINOSITOL 4-KINASE (PI4KIIALPHA) IN COMPLEX WITH ADP
Descriptor:Phosphatidylinositol 4-kinase type 2-alpha (E.C.2.7.1.67)
Authors:Zhou, Q., Zhai, Y., Zhang, K., Chen, C., Sun, F.
Deposit date:2012-10-19
Release date:2014-04-09
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
1E7U
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1e7u
STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (E.C.2.7.1.137)
Authors:Walker, E.H., Perisic, O., Ried, C., Stephens, L., Williams, R.L.
Deposit date:2000-09-08
Release date:2000-11-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
1E7V
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1e7v
STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (E.C.2.7.1.137)
Authors:Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L.
Deposit date:2000-09-08
Release date:2000-11-17
Modification date:2013-01-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin, and Staurosporine.
Mol.Cell, 6, 2000
1E8W
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1e8w
STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (E.C.2.7.1.137)
Authors:Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L.
Deposit date:2000-10-03
Release date:2000-11-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
1E8X
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1e8x
STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (E.C.2.7.1.137)
Authors:Walker, E.H., Perisic, O., Ried, C., Stephens, L., Williams, R.L.
Deposit date:2000-10-03
Release date:2000-10-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
1E8Y
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1e8y
STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (E.C.2.7.1.137)
Authors:Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L.
Deposit date:2000-10-03
Release date:2000-11-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
1E8Z
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1e8z
STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (E.C.2.7.1.137)
Authors:Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L.
Deposit date:2000-10-03
Release date:2000-11-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
1E90
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1e90
STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (E.C.2.7.1.137)
Authors:Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L.
Deposit date:2000-10-03
Release date:2000-11-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
1HE8
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1he8
RAS G12V - PI 3-KINASE GAMMA COMPLEX
Descriptor:PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM (E.C.2.7.1.137), TRANSFORMING PROTEIN P21/H-RAS-1
Authors:Pacold, M.E., Suire, S., Perisic, O., Lara-Gonzalez, S., Davis, C.T., Hawkins, P.T., Walker, E.H., Stephens, L., Eccleston, J.F., Williams, R.L.
Deposit date:2000-11-20
Release date:2001-01-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure and Functional Analysis of Ras Binding to its Effector Phosphoinositide 3-Kinase Gamma
Cell(Cambridge,Mass.), 103, 2000
2A4Z
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2a4z
CRYSTAL STRUCTURE OF HUMAN PI3KGAMMA COMPLEXED WITH AS604850
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform (E.C.2.7.1.153)
Authors:Camps, M., Ruckle, T., Ji, H., Ardissone, V., Rintelen, F., Shaw, J., Ferrandi, C., Chabert, C., Gillieron, C., Francon, B., Martin, T., Gretener, D., Perrin, D., Leroy, D., Vitte, P.-A., Hirsch, E., Wymann, M.P., Cirillo, R., Schwarz, M.K., Rommel, C.
Deposit date:2005-06-30
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
NAT.MED. (N.Y.), 11, 2005
2A5U
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2a5u
CRYSTAL STRUCTURE OF HUMAN PI3KGAMMA COMPLEXED WITH AS605240
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform (E.C.2.7.1.137)
Authors:Camps, M., Ruckle, T., Ji, H., Ardissone, V., Rintelen, F., Shaw, J., Ferrandi, C., Chabert, C., Gillieron, C., Francon, B., Martin, T., Gretener, D., Perrin, D., Leroy, D., Vitte, P.-A., Hirsch, E., Wymann, M.P., Cirillo, R., Schwarz, M.K., Rommel, C.
Deposit date:2005-07-01
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
NAT.MED. (N.Y.), 11, 2005
2CHW
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2chw
A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110 ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-39
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (E.C.2.7.1.137, 2.7.1.153)
Authors:Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.
Deposit date:2006-03-16
Release date:2006-05-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling
Cell(Cambridge,Mass.), 125, 2006
2CHX
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2chx
A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-90
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (E.C.2.7.1.137, 2.7.1.153)
Authors:Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.
Deposit date:2006-03-16
Release date:2006-05-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling
Cell(Cambridge,Mass.), 125, 2006
2CHZ
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2chz
A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-93
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (E.C.2.7.1.137, 2.7.1.153)
Authors:Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M.
Deposit date:2006-03-16
Release date:2006-05-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling
Cell(Cambridge,Mass.), 125, 2006
2RD0
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2rd0
STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEX
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (E.C.2.7.1.153), Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Huang, C., Gabelli, S.B., Amzel, L.M.
Deposit date:2007-09-20
Release date:2007-12-25
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science, 318, 2007
2V4L
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2v4l
COMPLEX OF HUMAN PHOSPHOINOSITIDE 3-KINASE CATALYTIC SUBUNIT GAMMA (P110 GAMMA) WITH PIK-284
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (E.C.2.7.1.153)
Authors:Apsel, B., Gonzalez, B., Blair, J.A., Nazif, T.M., Feldman, M.E., Williams, R.L., Shokat, K.M., Knight, Z.A.
Deposit date:2008-09-25
Release date:2008-10-14
Modification date:2013-04-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases.
Nat.Chem.Biol., 4, 2008
2WXF
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2wxf
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH PIK-39.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
2WXG
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2wxg
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH SW13.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
2WXH
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2wxh
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH SW14.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
2WXI
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2wxi
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH SW30.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
2WXJ
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2wxj
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH INK654.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
2WXK
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2wxk
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH INK666.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
2WXL
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2wxl
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH ZSTK474.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
2WXM
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2wxm
THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH DL06.
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)
Authors:Berndt, A., Miller, S., Williams, O., Lee, D.D., Houseman, B.T., Pacold, J.I., Gorrec, F., Hon, W.-C., Liu, Y., Rommel, C., Gaillard, P., Ruckle, T., Schwarz, M.K., Shokat, K.M., Shaw, J.P., Williams, R.L.
Deposit date:2009-11-09
Release date:2010-01-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6, 2010
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