8Q6H

HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 11)

Summary for 8Q6H

• Entry DOI: 10.2210/pdb8q6h/pdb
• Descriptor: Phosphatidylinositol 4-kinase beta, MAGNESIUM ION, 3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine, ... (5 entities in total)
• Functional Keywords: lipid kinase, transferase-signaling protein complex, covalent inhibitor., transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 49044.54

Authors

Somers, D.O. (deposition date: 2023-08-11, release date: 2023-12-13)

• Primary citation: Cosgrove, B.,Grant, E.K.,Bertrand, S.,Down, K.D.,Somers, D.O.,P Evans, J.,Tomkinson, N.C.O.,Barker, M.D.; Covalent targeting of non-cysteine residues in PI4KIII beta.; Rsc Chem Biol, 4:1111-1122, 2023; PubMed: 38033723; DOI: 10.1039/d3cb00142c

Experimental method

X-RAY DIFFRACTION (1.94 Å)