8Q6G
HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 8)
Summary for 8Q6G
Entry DOI | 10.2210/pdb8q6g/pdb |
Descriptor | Phosphatidylinositol 4-kinase beta, 3-(3,4-dimethoxyphenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | lipid kinase, transferase-signaling protein complex, covalent inhibitor., transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 49100.65 |
Authors | |
Primary citation | Cosgrove, B.,Grant, E.K.,Bertrand, S.,Down, K.D.,Somers, D.O.,P Evans, J.,Tomkinson, N.C.O.,Barker, M.D. Covalent targeting of non-cysteine residues in PI4KIII beta. Rsc Chem Biol, 4:1111-1122, 2023 Cited by PubMed: 38033723DOI: 10.1039/d3cb00142c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.541 Å) |
Structure validation
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