1KU2
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CRYSTAL STRUCTURE OF THERMUS AQUATICUS RNA POLYMERASE SIGMA SUBUNIT FRAGMENT CONTAINING REGIONS 1.2 TO 3.1
Descriptor:sigma factor sigA
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-04-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
1SIG
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CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE
Descriptor:RNA POLYMERASE PRIMARY SIGMA FACTOR
Authors:Malhotra, A., Severinova, E., Darst, S.A.
Deposit date:1997-02-18
Release date:1997-05-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.
Cell(Cambridge,Mass.), 87, 1996
3LES
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2F5 EPITOPE SCAFFOLD ES2
Descriptor:RNA polymerase sigma factor
Authors:Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Wyatt, R., Baker, D., Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Modification date:2010-11-24
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LEV
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HIV-1 ANTIBODY 2F5 IN COMPLEX WITH EPITOPE SCAFFOLD ES2
Descriptor:RNA polymerase sigma factor, 2F5 ANTIBODY LIGHT CHAIN, 2F5 ANTIBODY HEAVY CHAIN
Authors:Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D.
Deposit date:2010-01-15
Release date:2010-09-29
Modification date:2010-11-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107, 2010
3UGO
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CRYSTAL STRUCTURE OF RNA-POLYMERASE SIGMA SUBUNIT DOMAIN 2 COMPLEXED WITH -10 PROMOTER ELEMENT SSDNA OLIGO (TACAAT)
Descriptor:RNA polymerase sigma factor/DNA complex
Authors:Feklistov, A., Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Modification date:2012-03-07
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
3UGP
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CRYSTAL STRUCTURE OF RNA-POLYMERASE SIGMA SUBUNIT DOMAIN 2 COMPLEXED WITH -10 PROMOTER ELEMENT SSDNA OLIGO (TATAAT)
Descriptor:RNA polymerase sigma factor/DNA complex
Authors:Feklistov, A., Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Modification date:2012-03-07
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
4KI2
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CRYSTALLOGRAPHIC ANALYSIS OF AN RNA-POLYMERASE SIGMA-SUBUNIT FRAGMENT COMPLEXED WITH -10 PROMOTER ELEMENT SSDNA
Descriptor:RNA polymerase sigma factor/DNA Complex
Authors:Feklistov, A., Darst S.A.
Deposit date:2013-05-01
Release date:2013-09-04
Modification date:2014-09-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystallographic analysis of an RNA polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes.
Acta Crystallogr.,Sect.F, 69, 2013
4LJZ
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CRYSTAL STRUCTURE ANALYSIS OF THE E.COLI HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Bae, B., Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Modification date:2013-12-18
Method:X-RAY DIFFRACTION (3.5871 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LK0
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CRYSTAL STRUCTURE ANALYSIS OF THE E.COLI HOLOENZYME/T7 GP2 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD, Bacterial RNA polymerase inhibitor
Authors:Bae, B., Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Modification date:2013-12-18
Method:X-RAY DIFFRACTION (3.9103 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LK1
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CRYSTAL STRUCTURE ANALYSIS OF THE E.COLI HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Bae, B., Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Modification date:2013-12-18
Method:X-RAY DIFFRACTION (3.8369 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LLG
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CRYSTAL STRUCTURE ANALYSIS OF THE E.COLI HOLOENZYME/GP2 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD, Bacterial RNA polymerase inhibitor
Authors:Bae, B., Darst, S.A.
Deposit date:2013-07-09
Release date:2013-11-13
Modification date:2013-12-18
Method:X-RAY DIFFRACTION (3.7936 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4X8K
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MYCOBACTERIUM TUBERCULOSIS RBPA-SID IN COMPLEX WITH SIGMAA DOMAIN 2
Descriptor:Sigma A Domain 2, RbpA
Authors:Hubin, E.A., Flack, J.E., Tabib-Salazar, A., Paget, M.S., Darst, S.A., Campbell, E.A.
Deposit date:2014-12-10
Release date:2015-06-03
Modification date:2015-06-24
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.
Proc.Natl.Acad.Sci.USA, 112, 2015
1IW7
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CRYSTAL STRUCTURE OF THE RNA POLYMERASE HOLOENZYME FROM THERMUS THERMOPHILUS AT 2.6A RESOLUTION
Descriptor:RNA polymerase(E.C.2.7.7.6)
Authors:RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-04-22
Release date:2002-06-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
NATURE, 417, 2002
1L9U
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THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION
Descriptor:RNA polymerase holoenzyme
Authors:Murakami, K.S., Masuda, S., Darst, S.A.
Deposit date:2002-03-26
Release date:2002-05-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution.
Science, 296, 2002
1L9Z
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THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME/FORK-JUNCTION PROMOTER DNA COMPLEX AT 6.5 A RESOLUTION
Descriptor:RNA polymerase Holoenzyme/DNA
Authors:Murakami, K.S., Masuda, S., Campbell, E.A., Muzzin, O., Darst, S.A.
Deposit date:2002-03-27
Release date:2002-05-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (6.5 Å)
Cite:Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex.
Science, 296, 2002
1SMY
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STRUCTURAL BASIS FOR TRANSCRIPTION REGULATION BY ALARMONE PPGPP
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA POLYMERASE OMEGA SUBUNIT, principal sigma factor
Authors:Artsimovitch, I., Patlan, V., Sekine, S., Vassylyeva, M.N., Hosaka, T., Ochi, K., Yokoyama, S., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-03-10
Release date:2004-05-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for transcription regulation by alarmone ppGpp
Cell(Cambridge,Mass.), 117, 2004
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase (alpha, beta, beta', omega and sigma chains) (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2A68
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFABUTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-01
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A69
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFAPENTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6E
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6H
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC STERPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Temiakov, D., Zenkin, N., Vassylyeva, M.N., Perederina, A., Tahirov, T.H., Savkina, M., Zorov, S., Nikiforov, V., Igarashi, N., Matsugaki, N., Wakatsuki, S., Severinov, K., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2BE5
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH INHIBITOR TAGETITOXIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Svetlov, V., Vassylyeva, M.N., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Artsimovitch, I., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-10-22
Release date:2005-11-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3DXJ
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC MYXOPYRONIN
Descriptor:BACTERIAL RNA POLYMERASE ALPHA SUBUNIT; CHAIN A, B, K, L (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA-PRIME SUBUNIT; CHAIN D, N (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE OMEGA SUBUNIT; CHAIN E, O (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE SIGMA SUBUNIT; CHAIN F, P (E.C.2.7.7.6)
Authors:Das, K., Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
3EQL
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Vassylyeva, M.N., Artsimovitch, I.
Deposit date:2008-09-30
Release date:2008-10-28
Modification date:2009-01-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457, 2009
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