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1KU2
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1ku2
CRYSTAL STRUCTURE OF THERMUS AQUATICUS RNA POLYMERASE SIGMA SUBUNIT FRAGMENT CONTAINING REGIONS 1.2 TO 3.1
Descriptor:sigma factor sigA
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-04-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
3UGO
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3ugo
CRYSTAL STRUCTURE OF RNA-POLYMERASE SIGMA SUBUNIT DOMAIN 2 COMPLEXED WITH -10 PROMOTER ELEMENT SSDNA OLIGO (TACAAT)
Descriptor:RNA polymerase sigma factor/DNA complex
Authors:Feklistov, A., Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Modification date:2012-03-07
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
3UGP
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3ugp
CRYSTAL STRUCTURE OF RNA-POLYMERASE SIGMA SUBUNIT DOMAIN 2 COMPLEXED WITH -10 PROMOTER ELEMENT SSDNA OLIGO (TATAAT)
Descriptor:RNA polymerase sigma factor/DNA complex
Authors:Feklistov, A., Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Modification date:2012-03-07
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
4KI2
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4ki2
CRYSTALLOGRAPHIC ANALYSIS OF AN RNA-POLYMERASE SIGMA-SUBUNIT FRAGMENT COMPLEXED WITH -10 PROMOTER ELEMENT SSDNA
Descriptor:RNA polymerase sigma factor/DNA Complex
Authors:Feklistov, A., Darst S.A.
Deposit date:2013-05-01
Release date:2013-09-04
Modification date:2014-09-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystallographic analysis of an RNA polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes.
Acta Crystallogr.,Sect.F, 69, 2013
1IW7
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1iw7
CRYSTAL STRUCTURE OF THE RNA POLYMERASE HOLOENZYME FROM THERMUS THERMOPHILUS AT 2.6A RESOLUTION
Descriptor:RNA polymerase(E.C.2.7.7.6)
Authors:RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-04-22
Release date:2002-06-26
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
NATURE, 417, 2002
1L9U
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1l9u
THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION
Descriptor:RNA polymerase holoenzyme
Authors:Murakami, K.S., Masuda, S., Darst, S.A.
Deposit date:2002-03-26
Release date:2002-05-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution.
Science, 296, 2002
1L9Z
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1l9z
THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME/FORK-JUNCTION PROMOTER DNA COMPLEX AT 6.5 A RESOLUTION
Descriptor:RNA polymerase Holoenzyme/DNA
Authors:Murakami, K.S., Masuda, S., Campbell, E.A., Muzzin, O., Darst, S.A.
Deposit date:2002-03-27
Release date:2002-05-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (6.5 Å)
Cite:Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex.
Science, 296, 2002
1SMY
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1smy
STRUCTURAL BASIS FOR TRANSCRIPTION REGULATION BY ALARMONE PPGPP
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA POLYMERASE OMEGA SUBUNIT, principal sigma factor
Authors:Artsimovitch, I., Patlan, V., Sekine, S., Vassylyeva, M.N., Hosaka, T., Ochi, K., Yokoyama, S., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-03-10
Release date:2004-05-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for transcription regulation by alarmone ppGpp
Cell(Cambridge,Mass.), 117, 2004
1ZYR
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1zyr
STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase (alpha, beta, beta', omega and sigma chains) (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2A68
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2a68
CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFABUTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-01
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A69
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2a69
CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFAPENTIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6E
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2a6e
CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6H
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2a6h
CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC STERPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Temiakov, D., Zenkin, N., Vassylyeva, M.N., Perederina, A., Tahirov, T.H., Savkina, M., Zorov, S., Nikiforov, V., Igarashi, N., Matsugaki, N., Wakatsuki, S., Severinov, K., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2BE5
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2be5
CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH INHIBITOR TAGETITOXIN
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Svetlov, V., Vassylyeva, M.N., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Artsimovitch, I., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-10-22
Release date:2005-11-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12, 2005
2CW0
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2cw0
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain (E.C.2.7.7.6), RNA polymerase sigma factor rpoD (E.C.2.7.7.6)
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Modification date:2012-09-05
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3DXJ
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3dxj
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC MYXOPYRONIN
Descriptor:BACTERIAL RNA POLYMERASE ALPHA SUBUNIT; CHAIN A, B, K, L (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE BETA-PRIME SUBUNIT; CHAIN D, N (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE OMEGA SUBUNIT; CHAIN E, O (E.C.2.7.7.6), BACTERIAL RNA POLYMERASE SIGMA SUBUNIT; CHAIN F, P (E.C.2.7.7.6)
Authors:Das, K., Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
3EQL
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3eql
CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD
Authors:Vassylyev, D.G., Vassylyeva, M.N., Artsimovitch, I.
Deposit date:2008-09-30
Release date:2008-10-28
Modification date:2009-01-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457, 2009
3IYD
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3iyd
THREE-DIMENSIONAL EM STRUCTURE OF AN INTACT ACTIVATOR-DEPENDENT TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor rpoD, Catabolite gene activator/DNA complex
Authors:Hudson, B.P., Quispe, J., Lara, S., Kim, Y., Berman, H., Arnold, E., Ebright, R.H., Lawson, C.L.
Deposit date:2009-08-01
Release date:2009-11-10
Modification date:2011-07-13
Method:ELECTRON MICROSCOPY (19.799999 Å)
Cite:Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
3WOD
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3wod
RNA POLYMERASE-GP39 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor, Putative uncharacterized protein
Authors:Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor
Genes Dev., 28, 2014
4G7H
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4g7h
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7O
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4g7o
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 2 NT OF RNA
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7Z
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4g7z
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 5-BRU AT TEMPLATE-STRAND POSITION +1
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Modification date:2012-12-12
Method:X-RAY DIFFRACTION (3.815 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4IGC
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4igc
X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta (E.C.2.7.7.6), DNA-directed RNA polymerase subunit beta' (E.C.2.7.7.6), DNA-directed RNA polymerase subunit omega (E.C.2.7.7.6), RNA polymerase sigma factor RpoD
Authors:Murakami, K.S.
Deposit date:2012-12-17
Release date:2013-02-06
Modification date:2013-05-29
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:X-ray crystal structure of Escherichia coli RNA polymerase Sigma70 holoenzyme.
J.Biol.Chem., 288, 2013
4JK1
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4jk1
X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE TETRAPHOSPHATE (PPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta' subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase omega subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase sigma70 subunit
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-10
Modification date:2013-07-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JK2
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4jk2
X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE PENTAPHOSPHATE (PPPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase beta' subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase omega subunit (E.C.2.7.7.6), Escherichia coli RNA polymerase sigma70 subunit
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Modification date:2013-07-17
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
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