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1JKW
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1jkw
STRUCTURE OF CYCLIN MCS2
Descriptor:CYCLIN H
Authors:Andersen, G., Poterszman, A., Moras, D., Thierry, J.C.
Deposit date:1996-10-11
Release date:1997-01-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of human cyclin H.
FEBS Lett., 397, 1996
1KXU
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1kxu
CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Descriptor:CYCLIN H
Authors:Kim, K.K., Chamberin, H.M., Morgan, D.O., Kim, S.-H.
Deposit date:1996-08-08
Release date:1997-01-27
Modification date:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.
Nat.Struct.Biol., 3, 1996
2I53
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2i53
CRYSTAL STRUCTURE OF CYCLIN K
Descriptor:Cyclin K
Authors:Baek, K., Brown, R.S., Birrane, G., Ladias, J.A.A.
Deposit date:2006-08-23
Release date:2007-01-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J.Mol.Biol., 366, 2007
2IVX
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2ivx
CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION (CASP TARGET)
Descriptor:CYCLIN-T2
Authors:Debreczeni, J.E., Bullock, A.N., Fedorov, O., Savitsky, P., Berridge, G., Das, S., Pike, A.C.W., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Gorrec, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Von Delft, F., Knapp, S.
Deposit date:2006-06-21
Release date:2006-07-19
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of P-Tefb (Cdk9/Cyclin T1), its Complex with Flavopiridol and Regulation by Phosphorylation.
Embo J., 27, 2008
2PK2
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2pk2
CYCLIN BOX STRUCTURE OF THE P-TEFB SUBUNIT CYCLIN T1 DERIVED FROM A FUSION COMPLEX WITH EIAV TAT
Descriptor:Cyclin-T1
Authors:Anand, K., Schulte, A., Fujinaga, K., Scheffzek, K., Geyer, M.
Deposit date:2007-04-17
Release date:2007-07-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat.
J.Mol.Biol., 370, 2007
2W2H
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2w2h
STRUCTURAL BASIS OF TRANSCRIPTION ACTIVATION BY THE CYCLIN T1-TAT-TAR RNA COMPLEX FROM EIAV
Descriptor:CYCLIN-T1, PROTEIN TAT
Authors:Anand, K., Geyer, M.
Deposit date:2008-10-30
Release date:2008-12-09
Modification date:2009-10-06
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural Insights Into the Cyclin T1-Tat-Tar RNA Transcription Activation Complex from Eiav.
Nat.Struct.Mol.Biol., 15, 2008
1BU2
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1bu2
X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI
Descriptor:CYCLIN HOMOLOG
Authors:Schulze-Gahmen, U., Jung, J.U., Kim, S.-H.
Deposit date:1998-09-10
Release date:1999-06-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Structure Fold.Des., 7, 1999
1JOW
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1jow
CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN CDK6 AND A VIRAL CYCLIN
Descriptor:CYCLIN HOMOLOG/CELL DIVISION PROTEIN KINASE 6 (E.C.2.7.1.-)
Authors:Schulze-Gahmen, U., Kim, S.H.
Deposit date:2001-07-31
Release date:2002-02-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for CDK6 activation by a virus-encoded cyclin.
Nat.Struct.Biol., 9, 2002
1VIN
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1vin
BOVINE CYCLIN A3
Descriptor:CYCLIN A
Authors:Noble, M.E.M., Endicott, J.A.E., Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
1XO2
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1xo2
CRYSTAL STRUCTURE OF A HUMAN CYCLIN-DEPENDENT KINASE 6 COMPLEX WITH A FLAVONOL INHIBITOR, FISETIN
Descriptor:Cyclin, Cell division protein kinase 6 (E.C.2.7.1.37)
Authors:Lu, H.S., Chang, D.J., Baratte, B., Meijer, L., Schulze-Gahmen, U.
Deposit date:2004-10-05
Release date:2005-03-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin.
J.Med.Chem., 48, 2005
2B9R
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2b9r
CRYSTAL STRUCTURE OF HUMAN CYCLIN B1
Descriptor:G2/mitotic-specific cyclin B1
Authors:Basavappa, R., Petri, E.
Deposit date:2005-10-12
Release date:2006-10-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Human Cyclin B.
Cell Cycle, 6, 2007
2EUF
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2euf
X-RAY STRUCTURE OF HUMAN CDK6-VCYCLIN IN COMPLEX WITH THE INHIBITOR PD0332991
Descriptor:Cyclin homolog, Cell division protein kinase 6 (E.C.2.7.1.37)
Authors:Schulze-Gahmen, U., Lu, H.
Deposit date:2005-10-28
Release date:2006-07-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49, 2006
2F2C
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2f2c
X-RAY STRUCTURE OF HUMAN CDK6-VCYCLINWITH THE INHIBITOR AMINOPURVALANOL
Descriptor:Cyclin homolog, Cell division protein kinase 6 (E.C.2.7.1.37)
Authors:Schulze-Gahmen, U, Lu, H.
Deposit date:2005-11-16
Release date:2006-06-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49, 2006
2W96
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2w96
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-21
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W99
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2w99
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-22
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9F
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2w9f
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-23
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9Z
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2w9z
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-30
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
4BCM
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4bcm
STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2
Authors:Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCN
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4bcn
STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2
Authors:Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCQ
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4bcq
STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2
Authors:Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
1C9B
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1c9b
CRYSTAL STRUCTURE OF A HUMAN TBP CORE DOMAIN-HUMAN TFIIB CORE DOMAIN COMPLEX BOUND TO AN EXTENDED, MODIFIED ADENOVIRAL MAJOR LATE PROMOTER (ADMLP)
Descriptor:TATA-BOX BINDING PROTEIN, GENERAL TRANSCRIPTION FACTOR IIB/DNA COMPLEX
Authors:Tsai, F.T.F., Sigler, P.B.
Deposit date:1999-08-01
Release date:2000-01-10
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis of preinitiation complex assembly on human pol II promoters.
EMBO J., 19, 2000
1E9H
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1e9h
THR 160 PHOSPHORYLATED CDK2 - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR INDIRUBIN-5-SULPHONATE BOUND
Descriptor:CELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.37), CYCLIN A3
Authors:Davies, T.G., Tunnah, P., Noble, M.E.M., Endicott, J.A.
Deposit date:2000-10-16
Release date:2001-10-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate
Structure, 9, 2001
1F5Q
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1f5q
CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2
Descriptor:CELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.-)
Authors:Card, G.L., Knowles, P., Laman, H., Jones, N., McDonald, N.Q.
Deposit date:2000-06-15
Release date:2000-12-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a gamma-herpesvirus cyclin-cdk complex.
EMBO J., 19, 2000
1FIN
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1fin
CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
Descriptor:CYCLIN-DEPENDENT KINASE 2, CYCLIN A, ADENOSINE-5'-TRIPHOSPHATE
Authors:Jeffrey, P.D., Russo, A.A., Pavletich, N.P.
Deposit date:1996-07-14
Release date:1997-01-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature, 376, 1995
1FVV
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1fvv
THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.37)/CYCLIN A
Authors:Davis, S.T., Benson, B.G., Bramson, H.N., Chapman, D.E., Dickerson, S.H., Dold, K.M., Eberwein, D.J., Edelstein, M., Frye, S.V., Gampe Jr., R.T., Griffin, R.J., Harris, P.A., Hassell, A.M., Holmes, W.D., Hunter, R.N., Knick, V.B., Lackey, K., Lovejoy, B., Luzzio, M.J., Murray, D., Parker, P., Rocque, W.J., Shewchuk, L., Veal, J.M., Walker, D.H., Kuyper, L.K.
Deposit date:2000-09-20
Release date:2001-01-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291, 2001
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