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1JKW
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1jkw
STRUCTURE OF CYCLIN MCS2
Descriptor:CYCLIN H
Authors:Andersen, G., Poterszman, A., Moras, D., Thierry, J.C.
Deposit date:1996-10-11
Release date:1997-01-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of human cyclin H.
FEBS Lett., 397, 1996
1KXU
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1kxu
CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Descriptor:CYCLIN H
Authors:Kim, K.K., Chamberin, H.M., Morgan, D.O., Kim, S.-H.
Deposit date:1996-08-08
Release date:1997-01-27
Modification date:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.
Nat.Struct.Biol., 3, 1996
1ZP2
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1zp2
STRUCTURE OF THE MEDIATOR SUBUNIT CYCLIN C
Descriptor:RNA polymerase II holoenzyme cyclin-like subunit
Authors:Hoeppner, S., Baumli, S., Cramer, P.
Deposit date:2005-05-16
Release date:2005-07-19
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Mediator Subunit Cyclin C and its Implications for CDK8 Function.
J.Mol.Biol., 350, 2005
2I53
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2i53
CRYSTAL STRUCTURE OF CYCLIN K
Descriptor:Cyclin K
Authors:Baek, K., Brown, R.S., Birrane, G., Ladias, J.A.A.
Deposit date:2006-08-23
Release date:2007-01-02
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J.Mol.Biol., 366, 2007
2IVX
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2ivx
CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION (CASP TARGET)
Descriptor:CYCLIN-T2
Authors:Debreczeni, J.E., Bullock, A.N., Fedorov, O., Savitsky, P., Berridge, G., Das, S., Pike, A.C.W., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Gorrec, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Von Delft, F., Knapp, S.
Deposit date:2006-06-21
Release date:2006-07-19
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of P-Tefb (Cdk9/Cyclin T1), its Complex with Flavopiridol and Regulation by Phosphorylation.
Embo J., 27, 2008
1BU2
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1bu2
X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI
Descriptor:CYCLIN HOMOLOG
Authors:Schulze-Gahmen, U., Jung, J.U., Kim, S.-H.
Deposit date:1998-09-10
Release date:1999-06-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Structure Fold.Des., 7, 1999
1JOW
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1jow
CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN CDK6 AND A VIRAL CYCLIN
Descriptor:CYCLIN HOMOLOG/CELL DIVISION PROTEIN KINASE 6 (E.C.2.7.1.-)
Authors:Schulze-Gahmen, U., Kim, S.H.
Deposit date:2001-07-31
Release date:2002-02-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for CDK6 activation by a virus-encoded cyclin.
Nat.Struct.Biol., 9, 2002
1VIN
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1vin
BOVINE CYCLIN A3
Descriptor:CYCLIN A
Authors:Noble, M.E.M., Endicott, J.A.E., Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
1XO2
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1xo2
CRYSTAL STRUCTURE OF A HUMAN CYCLIN-DEPENDENT KINASE 6 COMPLEX WITH A FLAVONOL INHIBITOR, FISETIN
Descriptor:Cyclin, Cell division protein kinase 6 (E.C.2.7.1.37)
Authors:Lu, H.S., Chang, D.J., Baratte, B., Meijer, L., Schulze-Gahmen, U.
Deposit date:2004-10-05
Release date:2005-03-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin.
J.Med.Chem., 48, 2005
2B9R
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2b9r
CRYSTAL STRUCTURE OF HUMAN CYCLIN B1
Descriptor:G2/mitotic-specific cyclin B1
Authors:Basavappa, R., Petri, E.
Deposit date:2005-10-12
Release date:2006-10-17
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Human Cyclin B.
Cell Cycle, 6, 2007
2EUF
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2euf
X-RAY STRUCTURE OF HUMAN CDK6-VCYCLIN IN COMPLEX WITH THE INHIBITOR PD0332991
Descriptor:Cyclin homolog, Cell division protein kinase 6 (E.C.2.7.1.37)
Authors:Schulze-Gahmen, U., Lu, H.
Deposit date:2005-10-28
Release date:2006-07-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49, 2006
2F2C
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2f2c
X-RAY STRUCTURE OF HUMAN CDK6-VCYCLINWITH THE INHIBITOR AMINOPURVALANOL
Descriptor:Cyclin homolog, Cell division protein kinase 6 (E.C.2.7.1.37)
Authors:Schulze-Gahmen, U, Lu, H.
Deposit date:2005-11-16
Release date:2006-06-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49, 2006
2PK2
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2pk2
CYCLIN BOX STRUCTURE OF THE P-TEFB SUBUNIT CYCLIN T1 DERIVED FROM A FUSION COMPLEX WITH EIAV TAT
Descriptor:Cyclin-T1
Authors:Anand, K., Schulte, A., Fujinaga, K., Scheffzek, K., Geyer, M.
Deposit date:2007-04-17
Release date:2007-07-03
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat.
J.Mol.Biol., 370, 2007
2W2H
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2w2h
STRUCTURAL BASIS OF TRANSCRIPTION ACTIVATION BY THE CYCLIN T1-TAT-TAR RNA COMPLEX FROM EIAV
Descriptor:CYCLIN-T1, PROTEIN TAT
Authors:Anand, K., Geyer, M.
Deposit date:2008-10-30
Release date:2008-12-09
Modification date:2009-10-06
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural Insights Into the Cyclin T1-Tat-Tar RNA Transcription Activation Complex from Eiav.
Nat.Struct.Mol.Biol., 15, 2008
2W96
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2w96
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-21
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W99
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2w99
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-22
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9F
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2w9f
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-23
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9Z
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2w9z
CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (E.C.2.7.11.22)
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-30
Release date:2009-03-10
Modification date:2009-03-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
4OGR
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4ogr
CRYSTAL STRUCTURE OF P-TEFB COMPLEX WITH AFF4 AND TAT
Descriptor:Cyclin-dependent kinase 9 (E.C.2.7.11.22, 2.7.11.23), Cyclin-T1, AF4/FMR2 family member 4, Protein Tat
Authors:Schulze-Gahmen, U., Alber, T.
Deposit date:2014-01-16
Release date:2014-05-07
Modification date:2014-07-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.
Elife, 3, 2014
4TTH
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4tth
CRYSTAL STRUCTURE OF A CDK6/VCYCLIN COMPLEX WITH INHIBITOR BOUND
Descriptor:Cyclin homolog, Cyclin-dependent kinase 6 (E.C.2.7.11.22)
Authors:Piper, D.E., Walker, N., Wang, Z.
Deposit date:2014-06-20
Release date:2014-08-06
Modification date:2014-10-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
J.Med.Chem., 57, 2014
4UN0
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4un0
CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLINK COMPLEX
Descriptor:CYCLIN-K, CYCLIN-DEPENDENT KINASE 12 (E.C.2.7.11.22)
Authors:Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Chaikuad, A., Goubin, S., Krojer, T., Sorrell, F.J., Nowak, R., Williams, E., Kopec, J., Mahajan, R.P., Burgess-Brown, N., Carpenter, E.P., Knapp, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-05-22
Release date:2014-06-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal Structure of the Human Cdk12-Cyclink Complex
To be Published
4BCM
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4bcm
STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2
Authors:Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCN
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4bcn
STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2
Authors:Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCQ
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4bcq
STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2
Authors:Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
1E9H
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1e9h
THR 160 PHOSPHORYLATED CDK2 - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR INDIRUBIN-5-SULPHONATE BOUND
Descriptor:CELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.37), CYCLIN A3
Authors:Davies, T.G., Tunnah, P., Noble, M.E.M., Endicott, J.A.
Deposit date:2000-10-16
Release date:2001-10-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate
Structure, 9, 2001
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entries available on 2014-12-17
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