4TTH

Crystal structure of a CDK6/Vcyclin complex with inhibitor bound

Replaces:  4P41

Summary for 4TTH

• Entry DOI: 10.2210/pdb4tth/pdb
• Descriptor: Cyclin homolog, Cyclin-dependent kinase 6, 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine, ... (4 entities in total)
• Functional Keywords: kinase, transferase-cell cycle-inhibitor complex, transferase/cell cycle/inhibitor
• Biological source: Saimiriine herpesvirus 2 (SaHV-2); More
• Cellular location: Cytoplasm: Q00534
• Total number of polymer chains: 2
• Total formula weight: 66067.25

Authors

Piper, D.E.,Walker, N.,Wang, Z. (deposition date: 2014-06-20, release date: 2014-08-06, Last modification date: 2023-09-27)

• Primary citation: Li, Z.,Wang, X.,Eksterowicz, J.,Gribble, M.W.,Alba, G.Q.,Ayres, M.,Carlson, T.J.,Chen, A.,Chen, X.,Cho, R.,Connors, R.V.,DeGraffenreid, M.,Deignan, J.T.,Duquette, J.,Fan, P.,Fisher, B.,Fu, J.,Huard, J.N.,Kaizerman, J.,Keegan, K.S.,Li, C.,Li, K.,Li, Y.,Liang, L.,Liu, W.,Lively, S.E.,Lo, M.C.,Ma, J.,McMinn, D.L.,Mihalic, J.T.,Modi, K.,Ngo, R.,Pattabiraman, K.,Piper, D.E.,Queva, C.,Ragains, M.L.,Suchomel, J.,Thibault, S.,Walker, N.,Wang, X.,Wang, Z.,Wanska, M.,Wehn, P.M.,Weidner, M.F.,Zhang, A.J.,Zhao, X.,Kamb, A.,Wickramasinghe, D.,Dai, K.,McGee, L.R.,Medina, J.C.; Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.; J.Med.Chem., 57:3430-3449, 2014; PubMed: 24641103; DOI: 10.1021/jm500118j

Experimental method

X-RAY DIFFRACTION (2.9 Å)