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2X1V
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BU of 2x1v by Molmil
Crystal Structure of the activating H-Ras I163F mutant in Costello Syndrome, bound to MG-GDP
Descriptor: GTPASE HRAS, GUANOSINE-5'-DIPHOSPHATE
Authors:Anand, K.
Deposit date:2010-01-04
Release date:2010-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the Activating H-Ras I163F Mutant in Costello Syndrome, Bound to Mg-Gdp
To be Published
7NY8
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BU of 7ny8 by Molmil
Affimer K69 - KRAS protein complex
Descriptor: Affimer K69, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Turner, A.L, Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2021-03-21
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
1QG4
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BU of 1qg4 by Molmil
CANINE GDP-RAN F72Y MUTANT
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN)
Authors:Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M.
Deposit date:1999-04-20
Release date:1999-06-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.
J.Mol.Biol., 289, 1999
2KB0
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BU of 2kb0 by Molmil
Cdc42(T35A)
Descriptor: Cell division control protein 42 homolog
Authors:Adams, P.D, Oswald, R.E, McFeeters, R.
Deposit date:2008-11-18
Release date:2009-12-01
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Cdc42(T35A)
To be Published
221P
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BU of 221p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
1QRA
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BU of 1qra by Molmil
STRUCTURE OF P21RAS IN COMPLEX WITH GTP AT 100 K
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1
Authors:Scheidig, A, Burmester, C, Goody, R.S.
Deposit date:1999-06-12
Release date:1999-11-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.
Structure Fold.Des., 7, 1999
2A5J
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BU of 2a5j by Molmil
Crystal Structure of Human RAB2B
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-2B
Authors:Dong, A, Wang, J, Shen, Y, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC)
Deposit date:2005-06-30
Release date:2005-07-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Crystal structure of human RAB2B
To be Published
5MLB
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BU of 5mlb by Molmil
Crystal structure of human RAS in complex with darpin K27
Descriptor: DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
Deposit date:2016-12-06
Release date:2017-12-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
2LCF
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BU of 2lcf by Molmil
Solution structure of GppNHp-bound H-RasT35S mutant protein
Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Araki, M, Shima, F, Yoshikawa, Y, Muraoka, S, Ijiri, Y, Nagahara, Y, Shirono, T, Kataoka, T, Tamura, A.
Deposit date:2011-04-28
Release date:2011-09-28
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers.
J.Biol.Chem., 286, 2011
3KKQ
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BU of 3kkq by Molmil
Crystal structure of M-Ras P40D in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein M-Ras
Authors:Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
Deposit date:2009-11-06
Release date:2010-06-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
3KKM
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BU of 3kkm by Molmil
Crystal structure of H-Ras T35S in complex with GppNHp
Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
Deposit date:2009-11-06
Release date:2010-06-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
3KKP
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BU of 3kkp by Molmil
Crystal structure of M-Ras P40D in complex with GppNHp
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras
Authors:Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
Deposit date:2009-11-06
Release date:2010-06-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
1GWN
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BU of 1gwn by Molmil
The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho-related GTP-binding protein RhoE
Authors:Garavini, H, Riento, K, Phelan, J.P, McAlister, M.S.B, Ridley, A.J, Keep, N.H.
Deposit date:2002-03-19
Release date:2002-04-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Core Domain of Rhoe/Rnd3: A Constitutively Activated Small G Protein
Biochemistry, 41, 2002
4XVQ
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BU of 4xvq by Molmil
H-Ras Y137E
Descriptor: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
Authors:Johnson, C.W, Mattos, C.
Deposit date:2015-01-27
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.887 Å)
Cite:Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
1GNR
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BU of 1gnr by Molmil
X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION
Authors:Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1HUQ
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BU of 1huq by Molmil
1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE)
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB5C
Authors:Merithew, E, Hatherly, S, Dumas, J.J, Lawe, D.C, Heller-Harrison, R, Lambright, D.G.
Deposit date:2001-01-04
Release date:2001-02-07
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition.
J.Biol.Chem., 276, 2001
4XVR
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BU of 4xvr by Molmil
H-Ras Y137F
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Johnson, C.W, Mattos, C.
Deposit date:2015-01-27
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.031 Å)
Cite:Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
6E6C
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BU of 6e6c by Molmil
HRAS G13D bound to GppNHp (H13GNP)
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Johnson, C.W, Mattos, C.
Deposit date:2018-07-24
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
6E6H
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BU of 6e6h by Molmil
NRAS G13D bound to GppNHp (N13GNP)
Descriptor: GTPase NRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Johnson, C.W, Mattos, C.
Deposit date:2018-07-24
Release date:2019-07-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
6FA3
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BU of 6fa3 by Molmil
Antibody derived (Abd-6) small molecule binding to KRAS.
Descriptor: DIMETHYL SULFOXIDE, GTPase KRas, MAGNESIUM ION, ...
Authors:Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H.
Deposit date:2017-12-15
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6FA2
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BU of 6fa2 by Molmil
Antibody derived (Abd-5) small molecule binding to KRAS.
Descriptor: 4-[2-(dimethylamino)ethoxy]-~{N}-[[(3~{R})-5-(6-methoxypyridin-2-yl)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide, GTPase KRas, MAGNESIUM ION, ...
Authors:Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H.
Deposit date:2017-12-15
Release date:2018-09-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6FA4
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BU of 6fa4 by Molmil
Antibody derived (Abd-7) small molecule binding to KRAS.
Descriptor: 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[4-[(dimethylamino)methyl]phenyl]-2-methoxy-pyridin-3-amine, GTPase KRas, MAGNESIUM ION, ...
Authors:Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H.
Deposit date:2017-12-15
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6F76
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BU of 6f76 by Molmil
Antibody derived (Abd-8) small molecule binding to KRAS.
Descriptor: 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline, GTPase KRas, MAGNESIUM ION, ...
Authors:Bery, N, Cruz-Migoni, A, Quevedo, C.E, Phillips, S.V.E, Carr, S, Rabbitts, T.H.
Deposit date:2017-12-07
Release date:2018-08-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Elife, 7, 2018
5WHE
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BU of 5whe by Molmil
KRas G12V/D38P, bound to GppNHp and miniprotein 225-11
Descriptor: CALCIUM ION, GTPase KRas, MAGNESIUM ION, ...
Authors:Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L.
Deposit date:2017-07-16
Release date:2018-01-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
5WPL
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BU of 5wpl by Molmil
KRas G12V, bound to GppNHp and miniprotein 225-11
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Lee, S.-J, Shim, S.Y, McGee, J.H, Verdine, G.L.
Deposit date:2017-08-05
Release date:2018-01-03
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018

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