5FMW
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THE POLY-C9 COMPONENT OF THE COMPLEMENT MEMBRANE ATTACK COMPLEX
Descriptor:POLYC9
Authors:Dudkina, N.V., Spicer, B.A., Reboul, C.F., Conroy, P.J., Lukoyanova, N., Elmlund, H., Law, R.H.P., Ekkel, S.M., Kondos, S.C., Goode, R.J.A., Ramm, G., Whisstock, J.C., Saibil, H.R., Dunstone, M.A.
Deposit date:2015-11-10
Release date:2016-02-17
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Structure of the Poly-C9 Component of the Complement Membrane Attack Complex
Nat.Commun., 7, 2016
2M96
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SOLUTION NMR STRUCTURE OF THE RXFP2 LDLA MODULE
Descriptor:Relaxin receptor 2
Authors:Petrie, E.J., Gooley, P.R., Bathgate, A.D.
Deposit date:2013-06-03
Release date:2014-06-04
Method:SOLUTION NMR
Cite:Solution NMR structure of the RXFP2 LDLa module
To be Published
2M7P
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RXFP1 UTILISES HYDROPHOBIC MOIETIES ON A SIGNALLING SURFACE OF THE LDLA MODULE TO MEDIATE RECEPTOR ACTIVATION
Descriptor:entity
Authors:Kong, R.CK., Petrie, E.J., Mohanty, B., Ling, J., Lee, J.C.Y., Gooley, P.R., Bathgate, R.A.D.
Deposit date:2013-04-29
Release date:2013-08-14
Method:SOLUTION NMR
Cite:The relaxin receptor (RXFP1) utilises hydrophobic moieties on a signalling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation
J.Biol.Chem., 2013
2M0P
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SOLUTION STRUCTURE OF THE TENTH COMPLEMENT TYPE REPEAT OF HUMAN MEGALIN
Descriptor:Low-density lipoprotein receptor-related protein 2
Authors:Dagil, R., Kragelund, B.
Deposit date:2012-11-01
Release date:2013-01-09
Modification date:2013-06-19
Method:SOLUTION NMR
Cite:Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
J.Biol.Chem., 288, 2013
4E0S
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CRYSTAL STRUCTURE OF C5B-6
Descriptor:Complement C5, Complement component C6
Authors:Aleshin, A.E., Stec, B., DiScipio, R., Liddington, R.C.
Deposit date:2012-03-05
Release date:2012-04-18
Modification date:2012-06-20
Method:X-RAY DIFFRACTION (4.21 Å)
Cite:Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
4A5W
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CRYSTAL STRUCTURE OF C5B6
Descriptor:COMPLEMENT C5, COMPLEMENT COMPONENT C6
Authors:Hadders, M.A., Bubeck, D., Forneris, F., Pangburn, M., Llorca, O., Lea, S.M., Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Modification date:2012-10-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
3T5O
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT COMPONENT C6
Descriptor:Complement component C6
Authors:Aleshin, A.E., Stec, B., Bankston, L.A., DiScipio, R.G., Liddington, R.C.
Deposit date:2011-07-27
Release date:2012-02-01
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (2.869 Å)
Cite:Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
J.Biol.Chem., 287, 2012
2LGP
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SOLUTION STRUCTURE OF LA45 FROM LDLR
Descriptor:Low-density lipoprotein receptor
Authors:Guttman, M., Komives, E.A.
Deposit date:2011-08-01
Release date:2011-11-30
Modification date:2012-01-04
Method:SOLUTION NMR
Cite:The Structure, Dynamics, and Binding of the LA45 Module Pair of the Low-Density Lipoprotein Receptor Suggest an Important Role for LA4 in Ligand Release.
Biochemistry, 50, 2011
3P5C
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THE STRUCTURE OF THE LDLR/PCSK9 COMPLEX REVEALS THE RECEPTOR IN AN EXTENDED CONFORMATION
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low density lipoprotein receptor variant
Authors:Lo Surdo, P., Bottomley, M.J., Calzetta, A., Settembre, E.C., Cirillo, A., Pandit, S., Ni, Y., Hubbard, B., Sitlani, A., Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Modification date:2015-05-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
2XRC
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HUMAN COMPLEMENT FACTOR I
Descriptor:HUMAN COMPLEMENT FACTOR I (E.C.3.4.21.45)
Authors:Roversi, P., Johnson, S., Lea, S.M.
Deposit date:2010-09-13
Release date:2011-07-13
Modification date:2011-08-17
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
Proc.Natl.Acad.Sci.USA, 108, 2011
3OJY
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT COMPONENT C8
Descriptor:Complement component C8 alpha chain, Complement component C8 beta chain, Complement component C8 gamma chain
Authors:Lovelace, L.L., Cooper, C.L., Sodetz, J.M., Lebioda, L.
Deposit date:2010-08-23
Release date:2011-04-13
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
J.Biol.Chem., 286, 2011
3M0C
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THE X-RAY CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH THE LDL RECEPTOR
Descriptor:Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Low-density lipoprotein receptor
Authors:Spraggon, G., Hampton, E.N.
Deposit date:2010-03-02
Release date:2011-03-16
Method:X-RAY DIFFRACTION (7.01 Å)
Cite:The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
To be Published
2KNX
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SOLUTION STRUCTURE OF COMPLEMENT REPEAT CR17 FROM LRP-1
Descriptor:Prolow-density lipoprotein receptor-related protein 1
Authors:Guttman, M., Komives, E.
Deposit date:2009-09-07
Release date:2010-04-14
Modification date:2010-05-05
Method:SOLUTION NMR
Cite:Structure of the minimal interface between ApoE and LRP.
J.Mol.Biol., 398, 2010
2KNY
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FUSION CONSTRUCT OF CR17 FROM LRP-1 AND APOE RESIDUES 130-149
Descriptor:Prolow-density lipoprotein receptor-related protein 1
Authors:Guttman, M., Komives, E.A.
Deposit date:2009-09-08
Release date:2010-04-14
Modification date:2010-04-28
Method:SOLUTION NMR
Cite:Structure of the minimal interface between ApoE and LRP.
J.Mol.Biol., 398, 2010
2KRI
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STRUCTURE OF A COMPLEX BETWEEN DOMAIN V OF BETA2-GLYCOPROTEIN I AND THE FOURTH LIGAND-BINDING MODULE FROM LDLR DETERMINED WITH HADDOCK
Descriptor:Beta-2-glycoprotein 1, Low-density lipoprotein receptor
Authors:Beglova, N.
Deposit date:2009-12-18
Release date:2010-03-31
Method:SOLUTION NMR
Cite:Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids.
Structure, 18, 2010
3A7Q
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STRUCTURAL BASIS FOR SPECIFIC RECOGNITION OF REELIN BY ITS RECEPTORS
Descriptor:Reelin (E.C.3.4.21.-), Low-density lipoprotein receptor-related protein 8
Authors:Yasui, N., Nogi, T., Takagi, J.
Deposit date:2009-10-01
Release date:2010-03-23
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Specific Recognition of Reelin by Its Receptors
Structure, 18, 2010
3DPR
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HUMAN RHINOVIRUS 2 BOUND TO A CONCATAMER OF THE VLDL RECEPTOR MODULE V3
Descriptor:Protein VP1, Protein VP2, Protein VP3, Protein VP4, LDL-receptor class A 3
Authors:Querol-Audi, J., Pous, J., Fita, I., Verdaguer, N.
Deposit date:2008-07-09
Release date:2009-04-07
Modification date:2013-01-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Minor group human rhinovirus-receptor interactions: geometry of multimodular attachment and basis of recognition
Febs Lett., 583, 2009
2I1P
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SOLUTION STRUCTURE OF THE TWELFTH CYSTEINE-RICH LIGAND-BINDING REPEAT IN RAT MEGALIN
Descriptor:Low-density lipoprotein receptor-related protein 2
Authors:Wolf, C.A., Dancea, F., Shi, M., Bade-Noskova, V., Rueterjans, H., Kerjaschki, D., Luecke, C.
Deposit date:2006-08-14
Release date:2007-02-13
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin.
J.Biomol.Nmr, 37, 2007
2JM4
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THE SOLUTION NMR STRUCTURE OF THE RELAXIN (RXFP1) RECEPTOR LDLA MODULE.
Descriptor:Relaxin receptor 1
Authors:Hopkins, E.J., Bathgate, R.A.D., Gooley, P.R.
Deposit date:2006-10-09
Release date:2006-12-12
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation
J.Biol.Chem., 282, 2007
2FYJ
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NMR SOLUTION STRUCTURE OF CALCIUM-LOADED LRP DOUBLE MODULE
Descriptor:Low-density lipoprotein receptor-related protein 1
Authors:Jensen, G.A., Andersen, O.M., Bonvin, A.M., Bjerrum-Bohr, I., Etzerodt, M., O'shea, C., Poulsen, F.M., Kragelund, B.B.
Deposit date:2006-02-08
Release date:2006-10-10
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Binding Site Structure of One LRP-RAP Complex:Implications for a Common Ligand-Receptor Binding Motif.
J.Mol.Biol., 362, 2006
2FYL
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HADDOCK MODEL OF THE COMPLEX BETWEEN DOUBLE MODULE OF LRP, CR56, AND FIRST DOMAIN OF RECEPTOR ASSOCIATED PROTEIN, RAP-D1.
Descriptor:Alpha-2-macroglobulin receptor-associated protein, Low-density lipoprotein receptor-related protein 1
Authors:Jensen, G.A., Andersen, O.M., Bonvin, A.M., Bjerrum-Bohr, I., Etzerodt, M., O'shea, C., Poulsen, F.M., Kragelund, B.B.
Deposit date:2006-02-08
Release date:2006-10-10
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Binding Site Structure of One LRP-RAP Complex:Implications for a Common Ligand-Receptor Binding Motif.
J.Mol.Biol., 362, 2006
2FCW
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STRUCTURE OF A COMPLEX BETWEEN THE PAIR OF THE LDL RECEPTOR LIGAND-BINDING MODULES 3-4 AND THE RECEPTOR ASSOCIATED PROTEIN (RAP).
Descriptor:Alpha-2-macroglobulin receptor-associated protein precursor, Low-density lipoprotein receptor precursor
Authors:Beglova, N., Fisher, C., Blacklow, S.C.
Deposit date:2005-12-12
Release date:2006-05-16
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors
Mol.Cell, 22, 2006
1XFE
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SOLUTION STRUCTURE OF THE LA7-EGFA PAIR FROM THE LDL RECEPTOR
Descriptor:Low-density lipoprotein receptor
Authors:Beglova, N., Jeon, H., Fisher, C., Blacklow, S.C.
Deposit date:2004-09-14
Release date:2004-11-02
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Cooperation between Fixed and Low pH-Inducible Interfaces Controls Lipoprotein Release by the LDL Receptor
Mol.Cell, 16, 2004
1V9U
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HUMAN RHINOVIRUS 2 BOUND TO A FRAGMENT OF ITS CELLULAR RECEPTOR PROTEIN
Descriptor:Coat protein VP1/Coat protein VP2/Coat protein VP3/Coat protein VP4/LDL-receptor class A 3
Authors:Verdaguer, N., Fita, I., Reithmayer, M., Moser, R., Blaas, D.
Deposit date:2004-02-03
Release date:2004-05-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein
NAT.STRUCT.MOL.BIOL., 11, 2004
1N7D
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EXTRACELLULAR DOMAIN OF THE LDL RECEPTOR
Descriptor:Low-density lipoprotein receptor
Authors:Rudenko, G., Henry, L., Henderson, K., Ichtchenko, K., Brown, M.S., Goldstein, J.L., Deisenhofer, J.
Deposit date:2002-11-13
Release date:2003-01-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of the LDL receptor extracellular domain at endosomal pH
Science, 298, 2002
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