Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7PA2
DownloadVisualize
BU of 7pa2 by Molmil
PARK7 with inhibitor 8RK64
Descriptor: (3~{S})-~{N}-[5-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethanoyl]-6,7-dihydro-4~{H}-[1,3]thiazolo[5,4-c]pyridin-2-yl]-1-(iminomethyl)pyrrolidine-3-carboxamide, Parkinson disease protein 7
Authors:Kim, R.Q, Jia, Y, Sapmaz, A, Geurink, P.P.
Deposit date:2021-07-28
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput.
J.Med.Chem., 65, 2022
7PA3
DownloadVisualize
BU of 7pa3 by Molmil
PARK7 with covalent inhibitor JYQ-88
Descriptor: (3~{S})-~{N}-[5-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethanoyl]-6,7-dihydro-4~{H}-[1,3]thiazolo[5,4-c]pyridin-2-yl]-1-(iminomethyl)pyrrolidine-3-carboxamide, Parkinson disease protein 7
Authors:Kim, R.Q, Jia, Y, Sapmaz, A, Geurink, P.P.
Deposit date:2021-07-28
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput.
J.Med.Chem., 65, 2022
4ZGG
DownloadVisualize
BU of 4zgg by Molmil
Crystal structure of a DJ-1 (PARK7) from Homo sapiens at 1.23 A resolution
Descriptor: 1,2-ETHANEDIOL, Protein deglycase DJ-1
Authors:Joint Center for Structural Genomics (JCSG), Partnership for Nuclear Receptor Signaling Code Biology (NHRS), Partnership for T-Cell Biology (TCELL)
Deposit date:2015-04-22
Release date:2015-05-20
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structure of a DJ-1 (PARK7) from Homo sapiens at 1.23 A resolution
To be published
8PPW
DownloadVisualize
BU of 8ppw by Molmil
Structure of human PARK7 in complex with GK16S
Descriptor: (3~{S})-1-(iminomethyl)-~{N}-pent-4-ynyl-pyrrolidine-3-carboxamide, Parkinson disease protein 7
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-10
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
8PQ0
DownloadVisualize
BU of 8pq0 by Molmil
Structure of human PARK7 in complex with GK16R
Descriptor: (3~{R})-3-(pent-4-ynylcarbamoyl)pyrrolidine-1-carboximidothioic acid, Parkinson disease protein 7
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-10
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
1P5F
DownloadVisualize
BU of 1p5f by Molmil
Crystal Structure of Human DJ-1
Descriptor: RNA-binding protein regulatory subunit
Authors:Wilson, M.A, Collins, J.L, Hod, Y, Ringe, D, Petsko, G.A.
Deposit date:2003-04-26
Release date:2003-08-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The 1.1 A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease
Proc.Natl.Acad.Sci.USA, 100, 2003
7C62
DownloadVisualize
BU of 7c62 by Molmil
The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Biortus
Descriptor: GLYCEROL, Protein/nucleic acid deglycase DJ-1
Authors:Wang, F, Lin, D, Lv, Z, Tan, J.
Deposit date:2020-05-21
Release date:2020-07-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.027 Å)
Cite:The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Biortus.
To Be Published
5IP5
DownloadVisualize
BU of 5ip5 by Molmil
Human DJ-1 complexed with Na-K-tartrate
Descriptor: L(+)-TARTARIC ACID, Protein deglycase DJ-1
Authors:Lee, S, Cha, S.-S, An, Y.J.
Deposit date:2016-03-09
Release date:2017-03-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Human DJ-1 complexed with Na-K-tartrate
To Be Published
6M8Z
DownloadVisualize
BU of 6m8z by Molmil
Crystal structure of human DJ-1 without a modification on Cys-106
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Protein/nucleic acid deglycase DJ-1
Authors:Shumilin, I.A, Shabalin, I.G, Shumilina, S.V, Werenskjold, C, Utepbergenov, D, Minor, W.
Deposit date:2018-08-22
Release date:2018-09-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1.
Biochem. Biophys. Res. Commun., 504, 2018
6E5Z
DownloadVisualize
BU of 6e5z by Molmil
Crystal structure of human DJ-1 with a natural modification on Cys-106
Descriptor: CHLORIDE ION, Protein/nucleic acid deglycase DJ-1
Authors:Shumilin, I.A, Shumilina, S.V, Minor, W.
Deposit date:2018-07-23
Release date:2018-08-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1.
Biochem. Biophys. Res. Commun., 504, 2018
2OR3
DownloadVisualize
BU of 2or3 by Molmil
Pre-oxidation Complex of Human DJ-1
Descriptor: Protein DJ-1, SULFATE ION
Authors:Witt, A.C, Lakshminarasimhan, M, Wilson, M.A.
Deposit date:2007-02-01
Release date:2007-02-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
3SF8
DownloadVisualize
BU of 3sf8 by Molmil
Structural insights into thiol stabilization of DJ-1
Descriptor: Protein DJ-1
Authors:Premkumar, L, Dobaczewska, M.K, Riedl, S.J.
Deposit date:2011-06-13
Release date:2011-10-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Identification of an artificial peptide motif that binds and stabilizes reduced human DJ-1.
J.Struct.Biol., 176, 2011
4RKY
DownloadVisualize
BU of 4rky by Molmil
Crystal structure of DJ-1 isoform X1
Descriptor: Protein DJ-1
Authors:Liddington, R.C.
Deposit date:2014-10-14
Release date:2015-08-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014
4S0Z
DownloadVisualize
BU of 4s0z by Molmil
Crystal structure of M26V human DJ-1
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Protein DJ-1
Authors:Milkovic, N.M, Wilson, M.A.
Deposit date:2015-01-07
Release date:2015-08-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature.
Protein Sci., 24, 2015
4RKW
DownloadVisualize
BU of 4rkw by Molmil
Crystal structure of DJ-1
Descriptor: Protein DJ-1
Authors:Liddington, R.C.
Deposit date:2014-10-14
Release date:2015-08-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014
5SYA
DownloadVisualize
BU of 5sya by Molmil
Atomic resolution structure of D24N mutant human DJ-1
Descriptor: 1,2-ETHANEDIOL, Protein deglycase DJ-1
Authors:Wilson, M.A, Lin, J.
Deposit date:2016-08-10
Release date:2016-12-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons.
Biochemistry, 56, 2017
5SY9
DownloadVisualize
BU of 5sy9 by Molmil
Atomic resolution structure of E15Q mutant human DJ-1
Descriptor: 1,2-ETHANEDIOL, Protein deglycase DJ-1
Authors:Wilson, M.A, Lin, J.
Deposit date:2016-08-10
Release date:2016-12-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons.
Biochemistry, 56, 2017
5SY6
DownloadVisualize
BU of 5sy6 by Molmil
Atomic resolution structure of human DJ-1, DTT bound
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Protein deglycase DJ-1
Authors:Wilson, M.A, Lin, J.
Deposit date:2016-08-10
Release date:2016-12-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons.
Biochemistry, 56, 2017
1J42
DownloadVisualize
BU of 1j42 by Molmil
Crystal Structure of Human DJ-1
Descriptor: RNA-binding protein regulatory subunit
Authors:Cha, S.S.
Deposit date:2003-02-26
Release date:2004-02-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain.
J.Biol.Chem., 278, 2003
4BTE
DownloadVisualize
BU of 4bte by Molmil
DJ-1 Cu(I) complex
Descriptor: COPPER (I) ION, PROTEIN DJ-1
Authors:Puno, M.R.A, Odell, M, Moody, P.C.E.
Deposit date:2013-06-14
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structure of Cu(I)-Bound Dj-1 Reveals a Biscysteinate Metal Binding Site at the Homodimer Interface: Insights Into Mutational Inactivation of Dj-1 in Parkinsonism.
J.Am.Chem.Soc., 135, 2013
3B36
DownloadVisualize
BU of 3b36 by Molmil
Structure of M26L DJ-1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Protein DJ-1
Authors:Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A.
Deposit date:2007-10-19
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
3B38
DownloadVisualize
BU of 3b38 by Molmil
Structure of A104V DJ-1
Descriptor: 1,2-ETHANEDIOL, Protein DJ-1
Authors:Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A.
Deposit date:2007-10-19
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
3B3A
DownloadVisualize
BU of 3b3a by Molmil
Structure of E163K/R145E DJ-1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Protein DJ-1
Authors:Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A.
Deposit date:2007-10-19
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
3BWE
DownloadVisualize
BU of 3bwe by Molmil
Crystal structure of aggregated form of DJ1
Descriptor: PHOSPHATE ION, Protein DJ-1
Authors:Cha, S.S.
Deposit date:2008-01-09
Release date:2008-10-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner.
J.Biol.Chem., 283, 2008
2R1V
DownloadVisualize
BU of 2r1v by Molmil
Norepinephrine quinone conjugation to DJ-1
Descriptor: DJ-1
Authors:Zhongtao, Z, Yue, F.
Deposit date:2007-08-23
Release date:2008-08-26
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:DJ-1 activation by catechol quinone conjugation
To be Published

 

123>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon