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6CHT
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BU of 6cht by Molmil
HNF4alpha in complex with the corepressor EBP1 fragment
Descriptor: Hepatocyte nuclear factor 4-alpha, LAURIC ACID, Proliferation-associated protein 2G4
Authors:Chi, Y.I, Singh, P, Lee, I.K.
Deposit date:2018-02-22
Release date:2019-02-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.174 Å)
Cite:ErbB3-binding protein 1 (EBP1) represses HNF4 alpha-mediated transcription and insulin secretion in pancreatic beta-cells.
J.Biol.Chem., 294, 2019
1M7W
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BU of 1m7w by Molmil
HNF4a ligand binding domain with bound fatty acid
Descriptor: Hepatocyte nuclear factor 4-alpha, LAURIC ACID
Authors:Dhe-Paganon, S, Duda, K, Iwamoto, M, Chi, Y.I, Shoelson, S.E.
Deposit date:2002-07-22
Release date:2003-07-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
3FS1
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BU of 3fs1 by Molmil
Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment
Descriptor: Hepatocyte nuclear factor 4-alpha, MYRISTIC ACID, PPARgamma Coactivator-1a (PGC-1a)
Authors:Rha, G, Wu, G, Chi, Y.
Deposit date:2009-01-08
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation
J.Biol.Chem., 284, 2009
3CBB
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BU of 3cbb by Molmil
Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product
Descriptor: Hepatocyte Nuclear Factor 4-alpha promoter element DNA, Hepatocyte Nuclear Factor 4-alpha, DNA binding domain, ...
Authors:Lu, P, Rha, G.B, Melikishvili, M, Adkins, B.C, Fried, M.G, Chi, Y.I.
Deposit date:2008-02-21
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product.
J.Biol.Chem., 283, 2008
8C1L
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BU of 8c1l by Molmil
Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide
Descriptor: 1,2-ETHANEDIOL, Hepatocyte nuclear factor 4-alpha, Nuclear receptor coactivator 2, ...
Authors:Ni, X, Merk, D, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2022-12-20
Release date:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide
To Be Published
8PI9
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DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A)
Descriptor: Chains: E, Chains: F, Hepatocyte nuclear factor 1-alpha
Authors:Kind, L, Myllykoski, M, Raasakka, A, Kursula, P.
Deposit date:2023-06-21
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
8PI8
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DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA
Descriptor: Chains: E, Chains: F, GLYCEROL, ...
Authors:Kind, L, Myllykoski, M, Raasakka, A, Kursula, P.
Deposit date:2023-06-21
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
8PI7
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BU of 8pi7 by Molmil
DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -169C>T)
Descriptor: CHLORIDE ION, Chains: E, Chains: F, ...
Authors:Kind, L, Myllykoski, M, Raasakka, A, Kursula, P.
Deposit date:2023-06-21
Release date:2024-06-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
8PIA
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BU of 8pia by Molmil
DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>T)
Descriptor: Chains: E, Chains: F, GLYCEROL, ...
Authors:Kind, L, Myllykoski, M, Raasakka, A, Kursula, P.
Deposit date:2023-06-21
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
1LV2
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BU of 1lv2 by Molmil
Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids
Descriptor: Hepatocyte nuclear factor 4-gamma, PALMITIC ACID
Authors:Wisely, B, Miller, A.B, Davis, R.G, Spitzer, T, Shearer, B, Moore, J.T, Johnson, R, Sefler, A, Willson, T.M, Williams, S.P.
Deposit date:2002-05-24
Release date:2002-12-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids.
Structure, 10, 2002
1PZL
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Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide
Descriptor: Hepatocyte nuclear factor 4-alpha, MYRISTIC ACID, steroid receptor coactivator-1
Authors:Duda, K, Chi, Y.-I, Dhe-paganon, S, Shoelson, S.
Deposit date:2003-07-11
Release date:2004-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for HNF-4alpha Activation by Ligand and Coactivator Binding
J.Biol.Chem., 279, 2004
4IQR
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BU of 4iqr by Molmil
Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA
Descriptor: DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ...
Authors:Chandra, V, Huang, P, Kim, Y, Rastinejad, F.
Deposit date:2013-01-13
Release date:2013-03-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
Nature, 495, 2013
4B7W
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BU of 4b7w by Molmil
Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form
Descriptor: HEPATOCYTE NUCLEAR FACTOR 4-ALPHA
Authors:Dudasova, Z, Okvist, M, Kretova, M, Ondrovicova, G, Skrabana, R, LeGuevel, R, Salbert, G, Leonard, G, McSweeney, S, Barath, P.
Deposit date:2012-08-24
Release date:2013-09-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4 Å)
Cite:Fatty Acids are not Essential Structural Components of Hepatocyte Nuclear Factor 4Alpha
To be Published
1G5Y
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THE 2.0 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN TETRAMER IN THE PRESENCE OF A NON-ACTIVATING RETINOIC ACID ISOMER.
Descriptor: RETINOIC ACID, RETINOIC ACID RECEPTOR RXR-ALPHA
Authors:Gampe Jr, R.T, Montana, V.G, Lambert, M.H, Wisely, G.B, Milburn, M.V, Xu, H.E.
Deposit date:2000-11-02
Release date:2001-05-02
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
Genes Dev., 14, 2000
1G1U
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BU of 1g1u by Molmil
THE 2.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN IN TETRAMER IN THE ABSENCE OF LIGAND
Descriptor: RETINOIC ACID RECEPTOR RXR-ALPHA
Authors:Gampe Jr, R.T, Montana, V.G, Lambert, M.H, Wisely, G.B, Milburn, M.V, Xu, H.E.
Deposit date:2000-10-13
Release date:2001-04-25
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
Genes Dev., 14, 2000

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PDB entries from 2024-09-18

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