3CBB

Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product

Summary for 3CBB

Entry DOI	10.2210/pdb3cbb/pdb
Descriptor	Hepatocyte Nuclear Factor 4-alpha promoter element DNA, Hepatocyte Nuclear Factor 4-alpha, DNA binding domain, ZINC ION, ... (5 entities in total)
Functional Keywords	zinc finger, protein-dna complex, diabetes, transcription-dna complex, transcription/dna
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P41235
Total number of polymer chains	4
Total formula weight	31260.15
Authors	Lu, P.,Rha, G.B.,Melikishvili, M.,Adkins, B.C.,Fried, M.G.,Chi, Y.I. (deposition date: 2008-02-21, release date: 2008-10-07, Last modification date: 2024-02-21)
Primary citation	Lu, P.,Rha, G.B.,Melikishvili, M.,Wu, G.,Adkins, B.C.,Fried, M.G.,Chi, Y.I. Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product. J.Biol.Chem., 283:33685-33697, 2008 Cited by PubMed: 18829458 DOI: 10.1074/jbc.M806213200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation