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9BF2
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BU of 9bf2 by Molmil
MID domain of Ago2 bound to UMP
Descriptor: Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
3QX9
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BU of 3qx9 by Molmil
Crystal structure of MID domain from hAGO2 in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Protein argonaute-2
Authors:Frank, F, Fabian, M.R, Stepinski, J, Jemielity, J, Darzynkiewicz, E, Sonenberg, N, Nagar, B.
Deposit date:2011-03-01
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Embo Rep., 12, 2011
3QX8
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BU of 3qx8 by Molmil
Crystal structure of MID domain from hAGO2 in complex with m7GpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Protein argonaute-2
Authors:Frank, F, Fabian, M.R, Stepinski, J, Jemielity, J, Darzynkiewicz, E, Sonenberg, N, Nagar, B.
Deposit date:2011-03-01
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Embo Rep., 12, 2011
3LUD
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BU of 3lud by Molmil
Crystal structure of MID domain from hAGO2 in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUK
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BU of 3luk by Molmil
Crystal structure of MID domain from hAGO2
Descriptor: GLYCEROL, PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUH
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BU of 3luh by Molmil
Crystal structure of MID domain from hAGO2 in complex with GMP
Descriptor: GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUG
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BU of 3lug by Molmil
Crystal structure of MID domain from hAGO2 in complex with CMP
Descriptor: CYTIDINE-5'-MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUJ
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BU of 3luj by Molmil
Crystal structure of MID domain from hAGO2 in complex with UMP
Descriptor: Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUC
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BU of 3luc by Molmil
Crystal structure of MID domain from hAGO2
Descriptor: PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.691 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
9BF0
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BU of 9bf0 by Molmil
MID domain of human Argo2 bound to UTP
Descriptor: Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
9BEZ
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BU of 9bez by Molmil
MID domain of human Argo2 bound to RNA
Descriptor: Protein argonaute-2, [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
7C6B
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BU of 7c6b by Molmil
Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate
Descriptor: 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2
Authors:Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F.
Deposit date:2020-05-21
Release date:2020-11-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Rna, 27, 2021
7D7U
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BU of 7d7u by Molmil
Crystal structure of Ago2 MID domain in complex with 8-Br-adenosin-5'-monophosphate
Descriptor: 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, Protein argonaute-2
Authors:Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F.
Deposit date:2020-10-06
Release date:2020-11-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Rna, 27, 2021
8D6J
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BU of 8d6j by Molmil
Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence
Descriptor: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3')
Authors:Xiao, Y, MacRae, I.
Deposit date:2022-06-06
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
8D71
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BU of 8d71 by Molmil
Human Ago2 bound to miR122(21nt)
Descriptor: MAGNESIUM ION, Protein argonaute-2, miR-122-21nt
Authors:Xiao, Y, MacRae, I.
Deposit date:2022-06-07
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
3MJ0
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BU of 3mj0 by Molmil
Crystal Structure of Drosophia Ago-PAZ domain in complex with 3'-end 2'-O-methylated RNA
Descriptor: Protein argonaute-2, RNA (5'-R(*CP*GP*UP*UP*AP*CP*GP*CP*(OMU))-3')
Authors:Huang, Y, Ding, L, Ma, J.
Deposit date:2010-04-12
Release date:2011-05-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Crystal Structure of drosophila Ago2 PAZ domain in complex with 3'-end 2'-O-methylated RNA
To be Published
4G0M
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BU of 4g0m by Molmil
Crystal structure of Arabidopsis thaliana AGO2 MID domain
Descriptor: Protein argonaute 2, SULFATE ION
Authors:Frank, F, Hauver, J, Sonenberg, N, Nagar, B.
Deposit date:2012-07-09
Release date:2012-07-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.
Embo J., 31, 2012
2Q1O
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BU of 2q1o by Molmil
Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
Descriptor: RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3')
Authors:Li, F, Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
2Q1R
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BU of 2q1r by Molmil
Crystal Structure Analysis of the RNA Dodecamer CGCGAAUUAGCG, with a G-A mismatch.
Descriptor: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3')
Authors:Li, F, Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
7KI3
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BU of 7ki3 by Molmil
Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA
Descriptor: BARIUM ION, HCV genotype 1a miR-122 site-1, Protein argonaute-2, ...
Authors:Gebert, L.F.R, MacRae, I.J.
Deposit date:2020-10-22
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome.
Nat Commun, 12, 2021
6CBD
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BU of 6cbd by Molmil
Crystal Structure of Human Argonaute2 Bound to Three Tryptophans
Descriptor: Guide RNA, ISOPROPYL ALCOHOL, MAGNESIUM ION, ...
Authors:Sheu-Gruttadauria, J, MacRae, I.J.
Deposit date:2018-02-02
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Phase Transitions in the Assembly and Function of Human miRISC.
Cell, 173, 2018
4W5Q
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BU of 4w5q by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8
Descriptor: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
4W5R
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BU of 4w5r by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target)
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
6NIT
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BU of 6nit by Molmil
Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4)
Descriptor: Protein argonaute-2, RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3')
Authors:Sheu-Gruttadauria, J, MacRae, I.J.
Deposit date:2018-12-31
Release date:2019-08-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Basis for Target-Directed MicroRNA Degradation.
Mol.Cell, 75, 2019
5JS2
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BU of 5js2 by Molmil
Human Argonaute-2 Bound to a Modified siRNA
Descriptor: MAGNESIUM ION, PHENOL, PHOSPHATE ION, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2016-05-07
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.954 Å)
Cite:Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.
J.Am.Chem.Soc., 138, 2016

 

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