PDB: 7 resultsInfo pagesStatus searchChemie searchBIRD

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2LM0	Solution structure of the AF4-AF9 complex Descriptor: AF4/FMR2 family member 1/Protein AF-9 chimera Authors: Leach, B.I, Kuntimaddi, A, Schmidt, C.R, Cierpicki, T, Johnson, S.A, Bushweller, J.H. Deposit date: 2011-11-18 Release date: 2013-01-09 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Leukemia Fusion Target AF9 Is an Intrinsically Disordered Transcriptional Regulator that Recruits Multiple Partners via Coupled Folding and Binding. Structure, 21, 2013
6K7P	Crystal structure of human AFF4-THD domain Descriptor: AF4/FMR2 family member 4 Authors: Tang, D, Xue, Y, Li, S, Cheng, W, Duan, J, Wang, J, Qi, S. Deposit date: 2019-06-08 Release date: 2020-03-11 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription. Cell Discov, 6, 2020
6R80	Structure of AFF4 C-terminal homology domain Descriptor: AF4/FMR2 family member 4 Authors: Chen, Y, Cramer, P. Deposit date: 2019-03-30 Release date: 2019-06-12 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. J.Biol.Chem., 294, 2019
4OGR	crystal structure of P-TEFb complex with AFF4 and Tat Descriptor: ADENOSINE, AF4/FMR2 family member 4, Cyclin-T1, ... Authors: Schulze-Gahmen, U, Alber, T. Deposit date: 2014-01-16 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter. Elife, 3, 2014
4OR5	Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 Descriptor: AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... Authors: Gu, J, Babayeva, N.D, Suwa, Y, Baranovskiy, A.G, Price, D.H, Tahirov, T.H. Deposit date: 2014-02-10 Release date: 2014-04-16 Last modified: 2014-06-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle, 13, 2014
5JW9	The Crystal Structure of ELL2 Oclludin Domain and AFF4 peptide Descriptor: AF4/FMR2 family member 4, RNA polymerase II elongation factor ELL2 Authors: Qi, S, Hurley, J.H. Deposit date: 2016-05-11 Release date: 2017-02-08 Method: X-RAY DIFFRACTION (2.003 Å) Cite: Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. Nat Commun, 8, 2017
4IMY	The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat Descriptor: ADENOSINE MONOPHOSPHATE, AF4/FMR2 family member 4, Cyclin-T1, ... Authors: Alber, T, Schulze-Gahmen, U. Deposit date: 2013-01-03 Release date: 2013-03-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.94 Å) Cite: The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat. Elife, 2, 2013