4IMY
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
Summary for 4IMY
Entry DOI | 10.2210/pdb4imy/pdb |
Descriptor | Cyclin-dependent kinase 9, Cyclin-T1, AF4/FMR2 family member 4, ... (5 entities in total) |
Functional Keywords | transcriptional cdk9-cyct1 complex, phosphorylated, intrinsically disordered aff4, regulation of transcription elongation, ser/thr kinase, phosphorylation of polii-ctd, dsif, and nelf, hiv-1 tat, host-virus interaction, phosphoprotein, nucleus, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P50750 O60563 Q9UHB7 |
Total number of polymer chains | 9 |
Total formula weight | 233946.80 |
Authors | Alber, T.,Schulze-Gahmen, U. (deposition date: 2013-01-03, release date: 2013-03-13, Last modification date: 2023-09-20) |
Primary citation | Schulze-Gahmen, U.,Upton, H.,Birnberg, A.,Bao, K.,Chou, S.,Krogan, N.J.,Zhou, Q.,Alber, T. The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat. Elife, 2:e00327-e00327, 2013 Cited by PubMed: 23471103DOI: 10.7554/eLife.00327 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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