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7K59
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BU of 7k59 by Molmil
Structure of apo VCP hexamer generated from bacterially recombinant VCP/p97
Descriptor: Transitional endoplasmic reticulum ATPase
Authors:Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y.
Deposit date:2020-09-16
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation.
Iscience, 24, 2021
7K57
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BU of 7k57 by Molmil
Structure of apo VCP dodecamer generated from bacterially recombinant VCP/p97
Descriptor: Transitional endoplasmic reticulum ATPase
Authors:Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y.
Deposit date:2020-09-16
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation.
Iscience, 24, 2021
3QWZ
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BU of 3qwz by Molmil
Crystal structure of FAF1 UBX-p97N-domain complex
Descriptor: FAS-associated factor 1, Transitional endoplasmic reticulum ATPase
Authors:Park, J.K, Jeon, H, Lee, J.J, Kim, K.H, Lee, K.J, Kim, E.E.
Deposit date:2011-02-28
Release date:2012-05-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dissection of the interaction between FAF1 UBX and p97
To be Published
5FTM
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BU of 5ftm by Molmil
Cryo-EM structure of human p97 bound to ATPgS (Conformation II)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTK
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BU of 5ftk by Molmil
Cryo-EM structure of human p97 bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTL
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BU of 5ftl by Molmil
Cryo-EM structure of human p97 bound to ATPgS (Conformation I)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTJ
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BU of 5ftj by Molmil
Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor
Descriptor: 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5FTN
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BU of 5ftn by Molmil
Cryo-EM structure of human p97 bound to ATPgS (Conformation III)
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
Authors:Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
5G4G
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BU of 5g4g by Molmil
Structure of the ATPgS-bound VAT complex
Descriptor: VCP-LIKE ATPASE
Authors:Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L.
Deposit date:2016-05-12
Release date:2016-07-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
5G4F
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BU of 5g4f by Molmil
Structure of the ADP-bound VAT complex
Descriptor: VCP-LIKE ATPASE
Authors:Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L.
Deposit date:2016-05-12
Release date:2016-07-27
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
5GLF
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BU of 5glf by Molmil
Structural insights into the interaction of p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease
Descriptor: Derlin-1, Transitional endoplasmic reticulum ATPase
Authors:Lim, J.J, Lee, Y, Yoon, S.Y, Ly, T.T, Kang, J.Y, Youn, H.-S, An, J.Y, Lee, J.-G, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H.
Deposit date:2016-07-11
Release date:2016-11-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.
FEBS Lett., 590, 2016
6OAA
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BU of 6oaa by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6OA9
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BU of 6oa9 by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6OMB
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BU of 6omb by Molmil
Cdc48 Hexamer (Subunits A to E) with substrate bound to the central pore
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Cooney, I, Han, H, Stewart, M, Carson, R.H, Hansen, D, Price, J.C, Hill, C.P, Shen, P.S.
Deposit date:2019-04-18
Release date:2019-07-17
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.
Science, 365, 2019
5IFW
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BU of 5ifw by Molmil
Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Tether containing UBX domain for GLUT4, Transitional endoplasmic reticulum ATPase
Authors:Roske, Y, Heinemann, U.
Deposit date:2016-02-26
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Nat Commun, 7, 2016
4KDL
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BU of 4kdl by Molmil
Crystal structure of p97/VCP N in complex with OTU1 UBXL
Descriptor: Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1
Authors:Kim, S.J, Kim, E.E.
Deposit date:2013-04-25
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
5IFS
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BU of 5ifs by Molmil
Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ...
Authors:Roske, Y, Arumughan, A, Heinemann, U, Wanker, E.
Deposit date:2016-02-26
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Nat Commun, 7, 2016
6OAB
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BU of 6oab by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6OPC
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BU of 6opc by Molmil
Cdc48 Hexamer in a complex with substrate and Shp1(Ubx Domain)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Cooney, I, Han, H, Stewart, M, Carson, R.H, Hansen, D, Price, J.C, Hill, C.P, Shen, P.S.
Deposit date:2019-04-24
Release date:2019-07-10
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.
Science, 365, 2019
4KO8
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BU of 4ko8 by Molmil
Structure of p97 N-D1 R155H mutant in complex with ATPgS
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Xia, D, Tang, W.K.
Deposit date:2013-05-11
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
4KOD
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BU of 4kod by Molmil
Structure of p97 N-D1 R155H mutant in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Xia, D, Tang, W.K.
Deposit date:2013-05-11
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
4KLN
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BU of 4kln by Molmil
Structure of p97 N-D1 A232E mutant in complex with ATPgS
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Xia, D, Tang, W.K.
Deposit date:2013-05-07
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
4KDI
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BU of 4kdi by Molmil
Crystal structure of p97/VCP N in complex with OTU1 UBXL
Descriptor: Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1
Authors:Kim, S.J, Kim, E.E.
Deposit date:2013-04-25
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
5C1A
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BU of 5c1a by Molmil
p97-N750D/R753D/M757D/Q760D in complex with ATP-gamma-S
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Haenzelmann, P, Schindelin, H.
Deposit date:2015-06-13
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.
Structure, 24, 2016
8DAW
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BU of 8daw by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 2 (uD)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023

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