PDB: 46 resultsInfo pagesStatus searchChemie searchBIRD

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5F5D	Crystal structures and Inhibition kinetics reveal a two-state catalytic mechanism with drug design implications for rhomboid proteolysis Descriptor: Rhomboid protease GlpG Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5G	Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle Descriptor: ACE-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-04-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5K	E.Coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle Descriptor: Peptidic derivative of Gurken: ACE-ARG-LYS-VAL-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-02-10 Last modified: 2016-02-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5J	E.coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle Descriptor: Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde Authors: Urban, S, Cho, S, Dickey, S. Deposit date: 2015-12-04 Release date: 2016-02-10 Last modified: 2016-02-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
3UBB	The crystal structure of GlpG in complex with a phosphonofluoridate inhibitor Descriptor: Rhomboid protease glpG, propan-2-yl hydrogen (S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl]phosphonate Authors: Xue, Y, Ha, Y. Deposit date: 2011-10-24 Release date: 2012-06-13 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.601 Å) Cite: Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S' Subsites. Biochemistry, 51, 2012
3TXT	Crystal structure of GlpG in complex with inhibitor DFP Descriptor: DIISOPROPYL PHOSPHONATE, Rhomboid protease glpG Authors: Xue, Y, Ha, Y. Deposit date: 2011-09-23 Release date: 2011-12-07 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The crystal structure of rhomboid protease GlpG in complex with a mechanism-based inhibitor To be Published
3ZOT	Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 (data set 2) Descriptor: CHLORIDE ION, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside, ... Authors: Vinothkumar, K.R, Pierrat, O.A, Large, J.M, Freeman, M. Deposit date: 2013-02-24 Release date: 2013-05-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.399 Å) Cite: Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity. Structure, 21, 2013
3ZMH	Structure of E.coli rhomboid protease GlpG in complex with monobactam L62 Descriptor: CHLORIDE ION, CYCLOPENTYL 2-OXO-4-PHENYLAZETIDINE-1-CARBOXYLATE, RHOMBOID PROTEASE GLPG, ... Authors: Vinothkumar, K.R, Pierrat, O.A, Large, J.M, Freeman, M. Deposit date: 2013-02-11 Release date: 2013-05-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of rhomboid protease in complex with beta-lactam inhibitors defines the S2' cavity. Structure, 21, 2013
3ZMJ	Structure of E.coli rhomboid protease GlpG in complex with monobactam L61 Descriptor: 2-methylpropyl N-[(1R)-3-oxidanylidene-1-phenyl-propyl]carbamate, CHLORIDE ION, RHOMBOID PROTEASE GLPG, ... Authors: Vinothkumar, K.R, Pierrat, O, Large, J.M, Freeman, M. Deposit date: 2013-02-11 Release date: 2013-05-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity. Structure, 21, 2013
3ZEB	A complex of GlpG with isocoumarin inhibitor covalently bonded to serine 201 and histidine 150 Descriptor: 2-phenylethyl 2-(4-azanyl-2-methanoyl-phenyl)ethanoate, CHLORIDE ION, RHOMBOID PROTEASE GLPG, ... Authors: Vinothkumar, K.R, voskya, O, Kuettler, E.V, Brouwer, A.J, Liskamp, R.M.J, Verhelst, S.H.L. Deposit date: 2012-12-04 Release date: 2013-02-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Activity-Based Probes for Rhomboid Proteases Discovered in a Mass Spectrometry-Based Assay. Proc.Natl.Acad.Sci.USA, 110, 2013
3ZMI	Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 Descriptor: RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside, phenyl N-[(1R)-3-oxidanylidene-1-phenyl-propyl]carbamate Authors: Vinothkumar, K.R, Pierrat, O.A, Large, J.M, Freeman, M. Deposit date: 2013-02-11 Release date: 2013-05-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity. Structure, 21, 2013
6PJU	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-11-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJR	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: CHLORIDE ION, Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJA	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ5	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-27 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ9	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ7	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJQ	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-11-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ8	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJP	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ4	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-27 Release date: 2019-10-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

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