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5T7R
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BU of 5t7r by Molmil
A6-A11 trans-dicarba human insulin
Descriptor: Insulin A chain, Insulin B chain
Authors:Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E.
Deposit date:2016-09-05
Release date:2017-12-06
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.
Sci Rep, 7, 2017
5UU3
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BU of 5uu3 by Molmil
Insulin with proline analog DfP at position B28 in the R6 state
Descriptor: CHLORIDE ION, Insulin, chain A, ...
Authors:Lieblich, S.A, Fang, K.Y, Tirrell, D.A.
Deposit date:2017-02-16
Release date:2018-02-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insulin with proline analog DfP at position B28 in the R6 state
To Be Published
5UDP
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BU of 5udp by Molmil
High resolution x-ray crystal structure of synthetic insulin lispro
Descriptor: CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ...
Authors:Mandal, K, Dhayalan, B, Kent, S.B.H.
Deposit date:2016-12-28
Release date:2017-01-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.348 Å)
Cite:Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin.
Chemistry, 23, 2017
1HLS
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BU of 1hls by Molmil
NMR STRUCTURE OF THE HUMAN INSULIN-HIS(B16)
Descriptor: INSULIN
Authors:Ludvigsen, S, Kaarsholm, N.C.
Deposit date:1995-06-28
Release date:1995-09-15
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 33, 1994
1HO0
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BU of 1ho0 by Molmil
NEW B-CHAIN MUTANT OF BOVINE INSULIN
Descriptor: INSULIN
Authors:Dupradeau, F.Y, Richard, T, Le Flem, G, Oulyadi, H, Prigent, Y, Monti, J.P.
Deposit date:2000-12-08
Release date:2000-12-20
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A new B-chain mutant of insulin: comparison with the insulin crystal structure and role of sulfonate groups in the B-chain structure
J.Pept.Res., 60, 2002
1IGL
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BU of 1igl by Molmil
SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS
Descriptor: INSULIN-LIKE GROWTH FACTOR II
Authors:Torres, A.M, Forbes, B.E, Aplin, S.E, Wallace, J.C, Francis, G.L, Norton, R.S.
Deposit date:1994-12-29
Release date:1995-02-14
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions.
J.Mol.Biol., 248, 1995
1IZB
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BU of 1izb by Molmil
ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN
Descriptor: INSULIN, ZINC ION
Authors:Xiao, B, Dodson, G.G.
Deposit date:1992-10-16
Release date:1993-10-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin.
J.Mol.Biol., 228, 1992
1IOH
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BU of 1ioh by Molmil
INSULIN MUTANT A8 HIS,(B1, B10, B16, B27)GLU, DES-B30, NMR, 26 STRUCTURES
Descriptor: PROTEIN (INSULIN PRECURSOR)
Authors:Olsen, H.B, Ludvigsen, S, Kaarsholm, N.C.
Deposit date:1998-08-13
Release date:1999-01-13
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix.
J.Mol.Biol., 284, 1998
1IOG
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INSULIN MUTANT A3 GLY,(B1, B10, B16, B27)GLU, DES-B30, NMR, 19 STRUCTURES
Descriptor: PROTEIN (INSULIN PRECURSOR)
Authors:Olsen, H.B, Ludvigsen, S, Kaarsholm, N.C.
Deposit date:1998-08-13
Release date:1999-01-13
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix.
J.Mol.Biol., 284, 1998
1J73
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Crystal structure of an unstable insulin analog with native activity.
Descriptor: ZINC ION, insulin a, insulin b
Authors:Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1IMX
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BU of 1imx by Molmil
1.8 Angstrom crystal structure of IGF-1
Descriptor: BROMIDE ION, Insulin-like Growth Factor 1A, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE
Authors:Vajdos, F.F, Ultsch, M, Schaffer, M.L, Deshayes, K.D, Liu, J, Skelton, N.J, de Vos, A.M.
Deposit date:2001-05-11
Release date:2001-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.
Biochemistry, 40, 2001
1IZA
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BU of 1iza by Molmil
ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN
Descriptor: INSULIN
Authors:Xiao, B, Dodson, G.G.
Deposit date:1992-10-16
Release date:1993-10-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin.
J.Mol.Biol., 228, 1992
1JCO
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BU of 1jco by Molmil
Solution structure of the monomeric [Thr(B27)->Pro,Pro(B28)->Thr] insulin mutant (PT insulin)
Descriptor: Insulin A chain, Insulin B chain
Authors:Keller, D, Clausen, R, Josefsen, K, Led, J.J.
Deposit date:2001-06-11
Release date:2001-10-03
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Flexibility and bioactivity of insulin: an NMR investigation of the solution structure and folding of an unusually flexible human insulin mutant with increased biological activity.
Biochemistry, 40, 2001
1HUI
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BU of 1hui by Molmil
INSULIN MUTANT (B1, B10, B16, B27)GLU, DES-B30, NMR, 25 STRUCTURES
Descriptor: INSULIN
Authors:Olsen, H.B, Ludvigsen, S, Kaarsholm, N.C.
Deposit date:1996-03-29
Release date:1997-03-12
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Solution structure of an engineered insulin monomer at neutral pH.
Biochemistry, 35, 1996
1JCA
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BU of 1jca by Molmil
Non-standard Design of Unstable Insulin Analogues with Enhanced Activity
Descriptor: ZINC ION, insulin a, insulin b
Authors:Weiss, M.A, Wan, Z, Zhao, M, Chu, Y.-C, Nakagawa, S.H, Burke, G.T, Jia, W, Hellmich, R, Katsoyannis, P.G.
Deposit date:2001-06-08
Release date:2001-06-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1KMF
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BU of 1kmf by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor: Insulin
Authors:Xu, B, Hua, Q.X, Nakagawa, S.H, Jia, W, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2001-12-14
Release date:2002-01-09
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
J.Mol.Biol., 316, 2002
1HIQ
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BU of 1hiq by Molmil
PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS
Descriptor: INSULIN
Authors:Hua, Q.X, Shoelson, S.E, Inouye, K, Weiss, M.A.
Deposit date:1993-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proc.Natl.Acad.Sci.USA, 90, 1993
1K3M
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BU of 1k3m by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor: INSULIN
Authors:Xu, B, Hua, Q.-X, Nakagawa, S.H, Jia, W, Chu, Y.-C, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2001-10-03
Release date:2001-10-17
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.
Protein Sci., 11, 2002
1LKQ
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BU of 1lkq by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-GLY, VAL-A3-GLY, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor: INSULIN
Authors:Weiss, M.A, Hua, Q.X, Chu, Y.C, Jia, W, Philips, N.F, Wang, R.Y, Katsoyannis, P.G.
Deposit date:2002-04-25
Release date:2002-05-22
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
J.Biol.Chem., 277, 2002
1LPH
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BU of 1lph by Molmil
LYS(B28)PRO(B29)-HUMAN INSULIN
Descriptor: CHLORIDE ION, INSULIN, PHENOL, ...
Authors:Ciszak, E, Beals, J.M, Frank, B.H, Baker, J.C, Carter, N.D, Smith, G.D.
Deposit date:1995-04-19
Release date:1996-06-20
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin.
Structure, 3, 1995
2HH4
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BU of 2hh4 by Molmil
NMR structure of human insulin mutant GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures
Descriptor: insulin A chain, insulin B chain
Authors:Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A.
Deposit date:2006-06-27
Release date:2006-07-18
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
2HHO
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BU of 2hho by Molmil
NMR structure of human insulin mutant GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures
Descriptor: Insulin A chain, Insulin B chain
Authors:Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A.
Deposit date:2006-06-28
Release date:2006-07-18
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
2INS
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BU of 2ins by Molmil
THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN
Descriptor: DES-PHE B1 INSULIN (CHAIN A), DES-PHE B1 INSULIN (CHAIN B), ZINC ION
Authors:Smith, G.D, Duax, W.L, Dodson, E.J, Dodson, G.G, Degraaf, R.A.G, Reynolds, C.D.
Deposit date:1982-05-10
Release date:1982-08-05
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of Des-Phe B1 Bovine Insulin
Acta Crystallogr.,Sect.B, 38, 1982
2HIU
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BU of 2hiu by Molmil
NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES
Descriptor: INSULIN
Authors:Hua, Q.X, Gozani, S.N, Chance, R.E, Hoffmann, J.A, Frank, B.H, Weiss, M.A.
Deposit date:1996-10-08
Release date:1997-04-01
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
2G4M
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BU of 2g4m by Molmil
Insulin collected at 2.0 A wavelength
Descriptor: Insulin A chain, Insulin B chain
Authors:Mueller-Dieckmann, C, Weiss, M.S.
Deposit date:2006-02-22
Release date:2007-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths.
Acta Crystallogr.,Sect.D, 63, 2007

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