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8R0Z
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BU of 8r0z by Molmil
14-3-3 sigma in complex with TAZ peptide and stabilizing fragment TCF199
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, WW domain-containing transcription regulator protein 1, ...
Authors:Centorrino, F, Andlovic, B, Ottmann, C.
Deposit date:2023-11-01
Release date:2024-09-04
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction.
Biochemistry, 63, 2024
5WXN
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BU of 5wxn by Molmil
Structure of the LKB1 and 14-3-3 complex
Descriptor: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase STK11
Authors:Ding, S, Shi, Z.B.
Deposit date:2017-01-08
Release date:2017-04-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structure of the complex of phosphorylated liver kinase B1 and 14-3-3 zeta
Acta Crystallogr F Struct Biol Commun, 73, 2017
1QJA
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BU of 1qja by Molmil
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
Descriptor: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
Authors:Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
7EXE
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BU of 7exe by Molmil
Crystal structure of mouse 14-3-3zeta in complex with doubly phosphorylated ADAM22 peptide
Descriptor: 14-3-3 protein zeta/delta, Disintegrin and metalloproteinase domain-containing protein 22
Authors:Yan, L, Okatsu, K, Fukai, S.
Deposit date:2021-05-27
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:LGI1-ADAM22 levels regulate seizure thresholds through 14-3-3 in mice
Cell Rep, 2021
5MHC
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BU of 5mhc by Molmil
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, ...
Authors:Andrei, S, Ottmann, C, Leysen, S.
Deposit date:2016-11-24
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
4QLI
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BU of 4qli by Molmil
A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2014-06-12
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published
4WRQ
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BU of 4wrq by Molmil
Crystal Structure of 14-3-3 zeta with Chibby peptide
Descriptor: 14-3-3 protein zeta/delta, Chibby
Authors:Killoran, R.C, Shilton, B.H, Choy, W.Y.
Deposit date:2014-10-24
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Structural Analysis of the 14-3-3 zeta /Chibby Interaction Involved in Wnt/ beta-Catenin Signaling.
Plos One, 10, 2015
8HEW
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BU of 8hew by Molmil
Potato 14-3-3 St14f
Descriptor: 14-3-3 protein, StFDL1 peptide
Authors:Taoka, K, Kawahara, I, Shinya, S, Harada, K, Muranaka, T, Furuita, K, Nakagawa, A, Fujiwara, T, Tsuji, H, Kojima, C.
Deposit date:2022-11-08
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening.
Plant J., 112, 2022
4BG6
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BU of 4bg6 by Molmil
14-3-3 interaction with Rnd3 prenyl-phosphorylation motif
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ...
Authors:Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q.
Deposit date:2013-03-23
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins.
Cell(Cambridge,Mass.), 153, 2013
4Y3B
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BU of 4y3b by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma
Descriptor: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C
Authors:Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C.
Deposit date:2015-02-10
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
7V9B
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BU of 7v9b by Molmil
Crystal Structure of 14-3-3 epsilon with FOXO3a peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN, ...
Authors:Mathivanan, S, Kamariah, N.
Deposit date:2021-08-24
Release date:2022-08-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a 14-3-3 epsilon :FOXO3a pS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins.
Acs Omega, 7, 2022
8EQ8
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BU of 8eq8 by Molmil
The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y130
Descriptor: 14-3-3 protein beta/alpha
Authors:Zhu, P, Cooley, R.B.
Deposit date:2022-10-07
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation.
Protein Sci., 32, 2023
4Y32
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BU of 4y32 by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma
Descriptor: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC
Authors:Bartel, M, Milroy, L, Bier, D, Brunsveld, L, Ottmann, C.
Deposit date:2015-02-10
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
8EQH
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BU of 8eqh by Molmil
The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213
Descriptor: 14-3-3 protein beta/alpha
Authors:Zhu, P, Cooley, R.B.
Deposit date:2022-10-07
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation.
Protein Sci., 32, 2023
6NV2
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BU of 6nv2 by Molmil
14-3-3 sigma with RelA/p65 binding site pS45 in complex with DP005
Descriptor: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Wolter, M, Ottmann, C.
Deposit date:2019-02-04
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J.Am.Chem.Soc., 142, 2020
5HF3
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BU of 5hf3 by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma
Descriptor: 14-3-3 protein sigma, modified Tau peptide
Authors:Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C.
Deposit date:2016-01-06
Release date:2016-01-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
6KZH
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BU of 6kzh by Molmil
14-3-3 protein in Complex with CIC S173 phosphorylated peptide
Descriptor: 14-3-3 protein theta, CIC pS173 peptide
Authors:Wen, Y, Shao, Y.
Deposit date:2019-09-24
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.645 Å)
Cite:14-3-3 protein in Complex with CIC S173 phosphorylated peptide
To Be Published
2V7D
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BU of 2v7d by Molmil
14-3-3 protein zeta in complex with Thr758 phosphorylated integrin beta2 peptide
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, INTEGRIN BETA CHAIN, BETA 2 VARIANT
Authors:Takala, H, Ylanne, J.
Deposit date:2007-07-30
Release date:2008-06-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding.
Blood, 112, 2008
6KZG
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BU of 6kzg by Molmil
14-3-3 protein in Complex with CIC S301 phosphorylated peptide
Descriptor: 14-3-3 protein theta, ARG-SER-MET-SER-GLU-THR-GLY-THR
Authors:Wen, Y, Shao, Y.
Deposit date:2019-09-24
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:14-3-3 protein in Complex with CIC S301 phosphorylated peptide
To Be Published
1YWT
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BU of 1ywt by Molmil
Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1)
Authors:Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B.
Deposit date:2005-02-18
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A structural basis for 14-3-3sigma functional specificity.
J.Biol.Chem., 280, 2005
5IQP
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BU of 5iqp by Molmil
14-3-3 PROTEIN TAU ISOFORM
Descriptor: 14-3-3 protein theta, SULFATE ION
Authors:Xiao, B, Smerdon, S.J, Gamblin, S.J.
Deposit date:2016-03-11
Release date:2016-03-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
Nature, 376, 1995
7XBQ
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BU of 7xbq by Molmil
Crystal structure of potato 14-3-3 protein St14f
Descriptor: Putative 14-3-3 protein
Authors:Harada, K, Kojima, C, Yamashita, E, Nakagawa, A.
Deposit date:2022-03-21
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of potato 14-3-3 protein St14f revealed the importance of helix I in StFDL1 recognition.
Sci Rep, 12, 2022
2WH0
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BU of 2wh0 by Molmil
Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, CALCIUM ION, PROTEIN KINASE C EPSILON TYPE, ...
Authors:Kostelecky, B, Saurin, A.T, Purkiss, A, Parker, P.J, McDonald, N.Q.
Deposit date:2009-04-28
Release date:2009-08-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Recognition of an Intra-Chain Tandem 14-3-3 Binding Site within Pkc Epsilon.
Embo Rep., 10, 2009
1YZ5
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BU of 1yz5 by Molmil
The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution
Descriptor: 14-3-3 protein sigma
Authors:Benzinger, A, Popowicz, G.M, Holak, T.A, Hermeking, H.
Deposit date:2005-02-28
Release date:2005-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization.
Cell Res., 15, 2005
1A38
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BU of 1a38 by Molmil
14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE
Descriptor: 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP)
Authors:Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C.
Deposit date:1998-01-28
Release date:1999-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
J.Biol.Chem., 273, 1998

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數據於2024-09-18公開中

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